Results 161 to 170 of about 149,513 (318)

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause [PDF]

Mojgan Yazdanpanah, Nahid Yazdanpanah, Isabel Gamache, Ken K. Ong, John R. B. Perry, Despoina Manousaki   +5 more
openalex   +1 more source

Temporal effects of three-dimensional clinostat treatment on bone and serum metabolome in C57BL/J mice: a new method of simulating microgravity effect [PDF]

, 2022
Chenchen Song, Taisheng Kang, Meng Zhang, Kai Gao, Xudong Shi, Jianguo Guo   +5 more
openalex   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, EarlyView.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Single‐Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite‐Gene Correlation Network

Advanced Science
Metabolic studies at the single cell level can directly define the cellular phenotype closest to physiological or disease states. However, the current single cell metabolome (SCM) study using mass spectroscopy has difficulty giving a complete view of the
Xiying Mao, Dandan Xia, Miao Xu, Yan Gao, Le Tong, Chen Lu, Weiqi Li, Runmin Xie, Qinghuai Liu, Dechen Jiang, Songtao Yuan   +10 more
doaj   +1 more source

Peer Review #3 of "From the perspective of rumen microbiome and host metabolome, revealing the effects of feeding strategies on Jersey Cows on the Tibetan Plateau (v0.3)"

, 2023

openalex   +1 more source

The Impact of Metabolic Complications in Pregnancy on Later Life Maternal Cardiometabolic Health: Findings From the ROLO Longitudinal Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To explore associations between pregnancy metabolic complications and maternal cardiometabolic health 10 years postpartum. Design Prospective Longitudinal Cohort Study following a randomised controlled trial. Setting Single‐centre. Population Pregnancy metabolic complication (pregnancy‐induced hypertension, impaired glucose tolerance,
Kristyn Dunlop, Sophie Callanan, Kaat Philippe, Catherine McNestry, Alexander Douglass, Ricardo Segurado, Rachel K. Crowley, Patrick J. Twomey, Catherine M. Phillips, Fionnuala M. McAuliffe   +9 more
wiley   +1 more source

Transcriptome and metabolome of syntheticSolanumautotetraploids reveal key genomic stress events following polyploidization [PDF]

, 2016
Carlo Fasano, Gianfranco Diretto, Riccardo Aversano, Nunzio D’Agostino, Antonio Di Matteo, Luigi Frusciante, Giovanni Giuliano, Domenico Carputo   +7 more
openalex   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source