Results 61 to 70 of about 99,469 (217)

Metabolomic Profiling of Red Blood Cells to Identify Molecular Markers of Methotrexate Response in the Collagen Induced Arthritis Mouse Model

Future Pharmacology, 2022
Although methotrexate (MTX) is the first line disease-modifying therapy used in the treatment of autoimmune arthritis, it is limited by its unpredictable and variable response profile and lack of therapeutic biomarkers to predict or monitor therapeutic ...
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Ryan Sol Funk   +3 more
doaj   +1 more source

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data [PDF]

, 2013
<p>Motivation: Stable isotope-labelling experiments have recently gained increasing popularity in metabolomics studies, providing unique insights into the dynamics of metabolic fluxes, beyond the steady-state information gathered by routine mass ...
Achcar, Fiona,, Chokkathukalam, Achuthanunni, Creek, DJ, Barrett, M.P., Chokkathukalam, A., Breitling, Rainer, Creek, D.J., Breitling, R., Breitling, Rainer,, Achcar, Fiona, Achcar, F., Chokkathukalam, Achuthanunni,, Breitling, R, Jankevics, A, Jankevics, A., Jankevics, Andris, Creek, Darren J.,, Creek, Darren J., Achcar, F, Barrett, MP, Barrett, Michael P., Chokkathukalam, A, Jankevics, Andris,, Barrett, Michael P.,   +23 more
core   +1 more source

Metabolomics for the masses: The future of metabolomics in a personalized world

European Journal of Molecular & Clinical Medicine, 2017
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules.
Trivedi, Drupad; id_orcid 0000-0001-7969-0195, Hollywood, Katherine; id_orcid 0000-0002-7028-047X, Goodacre, Royston   +2 more
openaire   +4 more sources

Serum and Rumen Fluid Metabolome

, 2021
Rumen fluid and serum ...
Brooke Clemmons (7208798), Phillip Myer (4182211)   +1 more
core   +1 more source

Exploring the potential of saline mushrooms as a future food

Future Foods
Environmental changes require agri-food systems to adapt. Moreover, recent nutritional guidelines also reflect aspects of sustainable production and healthy nutrition while respecting planetary boundaries. In this context, mushrooms which have beneficial
Maria Fitzner-van Bömmel, Susanne Baldermann   +1 more
doaj   +1 more source

Metabolomics: A Primer [PDF]

Trends in Biochemical Sciences, 2017
Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of biochemical reactions, thus providing insights into multiple aspects of cellular physiology. Technological advances have enabled rapid and increasingly expansive data acquisition with samples as small
Xiaojing Liu, Jason W. Locasale
openaire   +2 more sources

Unraveling anti-inflammatory metabolic signatures of Glycyrrhiza uralensis and isoliquiritigenin through multiomics

npj Systems Biology and Applications
Glycyrrhiza uralensis, a key component of over 70% of traditional herbal medicines (Kampo) in Japan, exhibits diverse pharmacological effects, including immunoregulation, anti-tumor, and antioxidant properties.
Saki Kiuchi, Mi Hwa Chung, Hina Sakai, Taiki Nakaya, Katsuya Ohbuchi, Kazuya Tsumagari, Koshi Imami, Yasuhiro Otoguro, Tomoaki Nitta, Hiroyuki Yamamoto, Kazunori Sasaki, Hiroshi Tsugawa   +11 more
doaj   +1 more source

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Frontiers in Systems Neuroscience, 2013
Recent studies suggest that intestinal microbiota influences gut-brain communication. In this study, we aimed to clarify the influence of intestinal microbiota on cerebral metabolism. We analyzed the cerebral metabolome of germ-free (GF) mice and ex-germ-
Mitsuharu eMatsumoto, Ryoko eKibe, Takushi eOoga, Yuji eAiba, Emiko eSawaki, Yasuhiro eKoga, Yoshimi eBenno   +6 more
doaj   +1 more source

Systematic Analysis of Impact of Sampling Regions and Storage Methods on Fecal Gut Microbiome and Metabolome Profiles

mSphere, 2020
The contribution of human gastrointestinal (GI) microbiota and metabolites to host health has recently become much clearer. However, many confounding factors can influence the accuracy of gut microbiome and metabolome studies, resulting in ...
Yali Liang, Tianyu Dong, Minjian Chen, Lianping He, Tingzhang Wang, Xingyin Liu, Hang Chang, Jian-Hua Mao, Bo Hang, Antoine M. Snijders, Yankai Xia   +10 more
doaj   +1 more source

Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men

Metabolites, 2022
Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to ...
Jani P. Vaara, Heikki Kyröläinen, Tommi Vasankari, Heikki Kainulainen, Jani Raitanen, Urho M Kujala   +5 more
doaj   +1 more source