Results 61 to 70 of about 141,099 (288)

Systematic Analysis of Impact of Sampling Regions and Storage Methods on Fecal Gut Microbiome and Metabolome Profiles

mSphere, 2020
The contribution of human gastrointestinal (GI) microbiota and metabolites to host health has recently become much clearer. However, many confounding factors can influence the accuracy of gut microbiome and metabolome studies, resulting in ...
Yali Liang, Tianyu Dong, Minjian Chen, Lianping He, Tingzhang Wang, Xingyin Liu, Hang Chang, Jian-Hua Mao, Bo Hang, Antoine M. Snijders, Yankai Xia   +10 more
doaj   +1 more source

Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men

Metabolites, 2022
Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to ...
Jani P. Vaara, Heikki Kyröläinen, Tommi Vasankari, Heikki Kainulainen, Jani Raitanen, Urho M Kujala   +5 more
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Unraveling anti-inflammatory metabolic signatures of Glycyrrhiza uralensis and isoliquiritigenin through multiomics

npj Systems Biology and Applications
Glycyrrhiza uralensis, a key component of over 70% of traditional herbal medicines (Kampo) in Japan, exhibits diverse pharmacological effects, including immunoregulation, anti-tumor, and antioxidant properties.
Saki Kiuchi, Mi Hwa Chung, Hina Sakai, Taiki Nakaya, Katsuya Ohbuchi, Kazuya Tsumagari, Koshi Imami, Yasuhiro Otoguro, Tomoaki Nitta, Hiroyuki Yamamoto, Kazunori Sasaki, Hiroshi Tsugawa   +11 more
doaj   +1 more source

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei [PDF]

, 2013
n vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to make them more biologically relevant or to optimize growth is traditionally a laborious task.
Alsford, Alsford, Baltz, Barrett, Berger, Berger, Bitonti, Bowling, Bradley, Breitling, Brun, Brunda Nijagal, Creek, Creek, Creek, Darren J. Creek, de Koning, Dong-Hyun Kim, Drexler, Duszenko, Duszenko, Federico Rojas, Geary, Haanstra, Hasne, Hirumi, Hirumi, Hirumi, Jacobs, Keith R. Matthews, Kuettel, Kwon, Lanteri, Lanteri, Mashego, Michael P. Barrett, Mäser, Räz, Saunders, Scalbert, Scheltema, Scheltema, Seed, Sienkiewicz, Smith, Sumner, Sykes, t'Kindt, Tautenhahn, Vincent, Wang, Ward, Wilson, Winder, Wishart, Wu, Zaboikin, Zang, Zhang   +58 more
core   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Composition Characterization of Cinnamomum osmophloeum Kanehira Hydrosol and Its Enhanced Effects on Erectile Function

Plants
Cinnamomum osmophloeum Kanehira (CO) is an endemic species of Taiwan. This study elucidated the composition of CO hydrosol, revealing trans-cinnamaldehyde (65.03%), trans-cinnamyl acetate (7.57%), and coumarin (4.31%) as the main volatile compounds ...
Chung-Hsuan Wang, Nai-Wen Taso, Chi-Jung Chen, Hung-Yi Chang, Sheng-Yang Wang   +4 more
doaj   +1 more source

The gut microbiome-metabolome dataset collection: a curated resource for integrative meta-analysis

npj Biofilms and Microbiomes, 2022
Integrative analysis of microbiome and metabolome data obtained from human fecal samples is a promising avenue for better understanding the interplay between bacteria and metabolites in the human gut, in both health and disease.
Efrat Muller, Yadid M. Algavi, Elhanan Borenstein   +2 more
doaj   +1 more source

Maternal Serum and Placental Metabolomes in Association with Prenatal Phthalate Exposure and Neurodevelopmental Outcomes in the MARBLES Cohort

Metabolites, 2022
Prenatal exposure to phthalates, a family of endocrine-disrupting plasticizers, is associated with disruption of maternal metabolism and impaired neurodevelopment.
Mariana Parenti, Rebecca J. Schmidt, Sally Ozonoff, Hyeong-Moo Shin, Daniel J. Tancredi, Paula Krakowiak, Irva Hertz-Picciotto, Cheryl K. Walker, Carolyn M. Slupsky   +8 more
doaj   +1 more source

Plant Metabolomics Applications in the Brassicaceae: Added Value for Science and Industry [PDF]

, 2010
Crops from the family Brassicaceae represent a diverse and very interesting group of plants. In addition, their close relationship with the model plant, Arabidopsis thaliana, makes combined research on these species both scientifically valuable and of ...
Hall, R.D., Vos, C.H., de, Ward, J.
core   +3 more sources