Results 61 to 70 of about 108,734 (312)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Metabolomic Profiling of Red Blood Cells to Identify Molecular Markers of Methotrexate Response in the Collagen Induced Arthritis Mouse Model

Future Pharmacology, 2022
Although methotrexate (MTX) is the first line disease-modifying therapy used in the treatment of autoimmune arthritis, it is limited by its unpredictable and variable response profile and lack of therapeutic biomarkers to predict or monitor therapeutic ...
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Ryan Sol Funk   +3 more
doaj   +1 more source

Simplivariate Models: Ideas and First Examples [PDF]

, 2008
One of the new expanding areas in functional genomics is metabolomics: measuring the metabolome of an organism. Data being generated in metabolomics studies are very diverse in nature depending on the design underlying the experiment.
Werf, M.J. van der, Hendriks, M.M.W.B., Johan A. Westerhuis, Ruud Berger, Jos A Hageman, Westerhuis Johan A., Age K Smilde, Hendriks Margriet M. W. B., Smilde, A.K.; id_orcid, Mariët J. van der Werf, Johan A Westerhuis, Smilde, A.K., Berger, R., Age K. Smilde, Margriet M. W. B. Hendriks, Smilde Age K., Berger Ruud, Westerhuis, J.A., van der Werf, M.J., Jos A. Hageman, Hageman, J.A., Mariët J van der Werf, Hageman Jos A., Westerhuis, J.A.; id_orcid, Werf, M.J., van der, Margriet M W B Hendriks, van der Werf Mariët J.   +26 more
core   +3 more sources

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Phenology, Yield, and Fruit Composition of Diverse Grapevine Varieties

Australian Journal of Grape and Wine Research
Physiological diversity in grapevines is a key resource for developing climate-resilient varieties that exploit a broad spectrum of adaptive traits and help maintain wine quality under changing environmental conditions.
Lilith Weissflog, Patrick Pascal Lehr, Heiko Bastian, Victoria Goedde, Karsten Niehaus, Nikolaus Merkt, Christian Zörb   +6 more
doaj   +1 more source

Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas

Communications Biology, 2023
The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness.
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Karishma Rajani, Amanda Munoz-Casabella, Masum Rahman, Ali Gharibi-Loron, Desmond A. Brown, Kai J. Miller, Jaclyn J. White, Benjamin T. Himes, Ignacio Jusue-Torres, Samar Ikram, Seth C. Ransom, Renee Hirte, Ju-Hee Oh, William F. Elmquist, Jann N. Sarkaria, Rachael A. Vaubel, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, Terry C. Burns   +21 more
doaj   +1 more source

Microbiome and Metabolomics

Medical Journal of Babylon, 2023
The relationship between microbiome and metabolomics by studying the microbiota living in the human body and studying their effects on the concentration of metabolites, also to study effects of microbiota colonization on other bacteria or living organism entering the body.
Noor S K Al-Khafaji, Hussein O M Al-Dahmoshi, Zainab Adil Ghani Chabuck, Zena Abdul-Ameer Mahdi, Muhammad Akram, Adrish Sohail, Umme Laila, Rida Zainab, Muhammad Talha Khalil, Momina Iftikhar, Fethi Ahmet Ozdemir   +10 more
openaire   +2 more sources

Plasma metabolome cold exposure

, 2021
Metabolome - full list of metabolites before and after acute cold ...
Kovanicova, Z (via Mendeley Data)
core   +1 more source