Results 81 to 90 of about 141,099 (288)

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Diagnostic and Predictive Utility of Plasma Phosphoethanolamine Levels in Depressive Disorder: A Naturalistic Observational Study

International Journal of Methods in Psychiatric Research
Objectives Plasma phosphoethanolamine (PEA) has been proposed as a potential biomarker for depressive disorder. To further assess its diagnostic utility and relevance across psychiatric conditions, we conducted a larger observational study in a ...
Noriyuki Kawamura, Akinori Nakata, Tsuyoto Harada, Yoshiaki Ohashi, Hajime Sato, Kazunori Sasaki, Shoichiro Tsugane   +6 more
doaj   +1 more source

Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

Molecular Metabolism, 2018
Objective: Advances in the field of metabolomics and the concomitant development of bioinformatics tools constitute a promising avenue towards the development of precision medicine and personalized profiling for numerous disease states. Studies in animal
Shogo Sato, Evelyn B. Parr, Brooke L. Devlin, John A. Hawley, Paolo Sassone-Corsi   +4 more
doaj   +1 more source

The human serum metabolome. [PDF]

PLoS ONE, 2011
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized ...
Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart   +23 more
doaj   +1 more source

Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]

, 2018
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona, Barrett, Michael P., Goodyear, Carl S., Pountain, Andrew W., Rattigan, Kevin M., Regnault, Clement, Vincent, Isabel M.   +6 more
core   +3 more sources

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Thyroid Hormone Metabolites Quantified in Pup and Adult Rat Cerebellum, Cortex and Whole-Brain Samples Using an Automated Online SPE-LC-MS/MS Method

Metabolites
Changes in thyroid hormone (TH) levels in rat brain at early developmental stages are correlated with adverse effects on offspring development. To characterize the ability of substances to interfere with the TH concentrations in, e.g., rat brain, it is ...
Christiane Hindrichs, Tilmann Walk, Robert Landsiedel, Hennicke Kamp, Steffen Schneider, Stephanie Melching-Kollmuss, Dorothee Funk-Weyer   +6 more
doaj   +1 more source

Metabolomics for Biomarker Discovery in Gastroenterological Cancer

Metabolites, 2014
The study of the omics cascade, which involves comprehensive investigations based on genomics, transcriptomics, proteomics, metabolomics, etc., has developed rapidly and now plays an important role in life science research.
Shin Nishiumi, Makoto Suzuki, Takashi Kobayashi, Atsuki Matsubara, Takeshi Azuma, Masaru Yoshida   +5 more
doaj   +1 more source

Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future [PDF]

, 2016
Metabolomics and lipidomics are emerging methods for detailed phenotyping of small molecules in samples. It is hoped that such data will: (i) enhance baseline prediction of patient response to pharmacotherapies (beneficial or adverse); (ii) reveal ...
Preiss, David, Rankin, Naomi J., Sattar, Naveed, Welsh, Paul   +3 more
core   +2 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source