Results 51 to 60 of about 297,367 (349)

Suspect screening analysis to improve untargeted and targeted UHPLC-qToF approaches: the biodegradability of a proton pump inhibitor medicine and a natural medical device

Scientific Reports
Suspect screening and untargeted analysis using UHPLC-qToF are two advanced analytical approaches now used to achieve an extensive chemical profile of samples, which are then typically confirmed through targeted analysis.
Luisa Mattoli, Giacomo Proietti, Giada Fodaroni, Claudio Marzio Quintiero, Michela Burico, Mattia Gianni, Emiliano Giovagnoni, Valentino Mercati, Claudio Santi   +8 more
doaj   +1 more source

Beetroot juice — a suitable post-marathon metabolic recovery supplement?

Journal of the International Society of Sports Nutrition, 2021
Background Red beetroot (Beta vulgaris L.) is a multifunctional functional food that reportedly exhibits potent anti-inflammatory, antioxidant, vasodilation, and cellular regulatory properties.
Zinandré Stander, Laneke Luies, Mari van Reenen, Glyn Howatson, Karen M. Keane, Tom Clifford, Emma J. Stevenson, Du Toit Loots   +7 more
doaj   +1 more source

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

Journal of the American Society for Mass Spectrometry, 2021
Biological systems are composed of heterogeneous populations of cells that intercommunicate to form a functional living tissue. Biological function varies greatly across populations of cells, as each single cell has a unique transcriptome, proteome, and ...
Michael J Taylor, J. Lukowski, C. Anderton   +2 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Data on the optimisation of a solid phase extraction method for fractionating estrogen metabolites from small urine volumes

Data in Brief, 2020
Certain estrogen metabolites have been implicated in the pathophysiology of breast cancer. Moreover, the estrogen metabolite profiles of healthy women and those with (a high risk of) breast cancer differ significantly.
Carien L. van der Berg, Gerda Venter, Francois H. van der Westhuizen, Elardus Erasmus   +3 more
doaj   +1 more source

3,4-dimethoxychalcone induces autophagy and reduces neointimal hyperplasia and aortic lesions in mouse models of atherosclerosis

Cell Death and Disease, 2023
Autophagy inducers can prevent cardiovascular aging and age-associated diseases including atherosclerosis. Therefore, we hypothesized that autophagy-inducing compounds that act on atherosclerosis-relevant cells might have a protective role in the ...
Giulia Cerrato, Carlota Alvarez-Lucena, Allan Sauvat, Yanhua Hu, Sabrina Forveille, Guo Chen, Sylvère Durand, Fanny Aprahamian, Marion Leduc, Omar Motiño, Lisardo Boscá, Qingbo Xu, Oliver Kepp, Guido Kroemer   +13 more
doaj   +1 more source

New software tools, databases, and resources in metabolomics: updates from 2020

Metabolomics, 2021
Precision medicine, space exploration, drug discovery to characterization of dark chemical space of habitats and organisms, metabolomics takes a centre stage in providing answers to diverse biological, biomedical, and environmental questions.
B. Misra
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Diagnostic, Prognostic and Mechanistic Biomarkers of COVID-19 Identified by Mass Spectrometric Metabolomics

Metabolites, 2023
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19 severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic and prognostic biomarkers.
Mélanie Bourgin, Sylvère Durand, Guido Kroemer   +2 more
doaj   +1 more source

Challenges in Metabolomics-Based Tests, Biomarkers Revealed by Metabolomic Analysis, and the Promise of the Application of Metabolomics in Precision Medicine

International Journal of Molecular Sciences, 2022
Metabolomics helps identify metabolites to characterize/refine perturbations of biological pathways in living organisms. Pre-analytical, analytical, and post-analytical limitations that have hampered a wide implementation of metabolomics have been ...
A. Di Minno, M. Gelzo, M. Caterino, M. Costanzo, M. Ruoppolo, G. Castaldo   +5 more
semanticscholar   +1 more source