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LC–MS-Based Metabonomics Analysis

open access: yesJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2008
Metabonomics aims at the comprehensive and quantitative analysis of wide arrays of metabolites in biological samples. It has shown particular promise in the areas of toxicology and drug development, functional genomics, systems biology, and clinical ...
Xin Lu, Guowang Xu, Xinjie Zhao
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A Decade of Advances in Metabonomics

Expert Opinion on Drug Metabolism and Toxicology, 2011
The metabonomic approach to biological analysis has demonstrated considerable success in obtaining and decoding metabolic signatures of health, disease and biological challenge. The rise of metabonomics to join the principal 'omics' streams in medical research has been enhanced in particular over the last 10 years by developments in modelling methods ...
Richard H Barton
exaly   +3 more sources

Metabonomics and Diagnostics

2015
Metabonomic techniques have considerable potential in the field of clinical diagnostics, typifying the application of a translational research paradigm. Care must be taken at all stages to apply appropriate methodology with accurate patient selection and profiling, and rigorous data acquisition and handling, to ensure clinical validity.An ever ...
Lucy C, Hicks   +2 more
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Metabonomics and Toxicology

2015
Being an emerging field of "omics" research, metabonomics has been increasingly used in toxicological studies mostly because this technology has the ability to provide more detailed information to elucidate mechanism of toxicity. As an interdisciplinary field of science, metabonomics combines analytical chemistry, bioinformatics, statistics, and ...
Liang, Zhao, Thomas, Hartung
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Metabonomics and the endocrine system

Molecular and Cellular Endocrinology, 2005
Proton-NMR-based metabonomics offers a rare opportunity as a definitive screening technique for biofluids and tissue biopsies. The procedure is extraordinary in that it allows the 'complete biochemical picture' to be examined at one time and is able to detect subtle but repeatedly consistent disparities that may be occurring in different, and perhaps ...
S C, Mitchell, P L, Carmichael
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Metabonomics and diabetes mellitus

Advances in Therapy, 2007
Diabetes mellitus is one of the most serious heterogeneous endocrinologic diseases; more than 90% of those given this diagnosis have type 2 diabetes mellitus, usually accompanied by macrovascular and microvascular complications. Because most cases include a 7- to 10-y latency period before disease onset, however, it is of vital importance that more ...
Peng, Chen, Jicheng, Liu
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Metabolomics and Metabonomics

2004
Metabolism is the ensemble of chemical transformations carried out in living tissue; operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (M r .
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Analytical Strategies in Metabonomics

Journal of Proteome Research, 2006
To perform metabonomics investigations, it is necessary to generate comprehensive metabolite profiles for complex samples such as biofluids and tissue/tissue extracts. Analytical technologies that can be used to achieve this aim are constantly evolving, and new developments are changing the way in which such profiles' metabolite profiles can be ...
Eva Maria, Lenz, Ian D, Wilson
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INTRODUCTION TO METABONOMICS

2022
Authors : Dr. SHATAKSHI SRIVASTAVA; Prof.
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