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Metabonomics in Preclinical Drug Development
Expert Opinion on Drug Metabolism and Toxicology, 2005Metabonomics has emerged as a key technology in preclinical drug discovery and development. The technology enables noninvasive systems assessment of untoward effects induced by candidate compounds characterising a broad spectrum of biological responses on an individual animal basis in a relatively rapid-throughput fashion, thus making it an ideal ...
Michael D. Reily, Donald G Robertson
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Metabonomics and Drug Development
2015Metabolites as an end product of metabolism possess a wealth of information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, and environment. Studying significant changes in the metabolite patterns has been recognized as a tool to understand crucial aspects in drug development like drug ...
Pranov, Ramana +3 more
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2006
Metabonomics is the study of systemic biochemical profiles and regulation of function in whole organisms by analyzing biofluids and tissues. Like genomics (the study of the complete repertoire of genes in an organism) and proteomics (the study of the protein complement of a tissue or cell), metabonomics can provide a holistic overview of the current ...
David J. Grainger, Jeremy K. Nicholson
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Metabonomics is the study of systemic biochemical profiles and regulation of function in whole organisms by analyzing biofluids and tissues. Like genomics (the study of the complete repertoire of genes in an organism) and proteomics (the study of the protein complement of a tissue or cell), metabonomics can provide a holistic overview of the current ...
David J. Grainger, Jeremy K. Nicholson
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Spectroscopic and Statistical Methods in Metabonomics
Bioanalysis, 2009Metabonomics is rapidly evolving through advances in analytical technologies together with the development of new hyphenated approaches that are increasingly being applied to analyze complex biological systems. Improvements in analytical performance, such as increased sensitivity and selectivity, are providing greater resolution to analytical datasets ...
Daniel S, Waterman +2 more
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The correspondence problem for metabonomics datasets
Analytical and Bioanalytical Chemistry, 2009In metabonomics it is difficult to tell which peak is which in datasets with many samples. This is known as the correspondence problem. Data from different samples are not synchronised, i.e., the peak from one metabolite does not appear in exactly the same place in all samples.
K Magnus, Aberg +2 more
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Applications of Metabonomics in Pesticide Toxicology
Current Drug Metabolism, 2015Metabonomic studies quantitatively measure the small molecule metabolites and their intermediates in the biological samples (serum, urine or tissue extracts) and have gained wide applications in many fields, especially in toxicology. Pesticides are extensively used around the world and pesticide toxicity has become a serious threat to human health ...
Pan, Wang, Yi-Jun, Wu
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Application of Metabonomics in Drug Development
Pharmacogenomics, 2007Metabolic profiling (metabonomics/metabolomics) is the untargeted analysis of metabolic composition in a biological sample, and is principally aimed at biomarker discovery. The frequent use of noninvasive biofluid analysis in metabonomics is suited to the clinic and facilitates dynamic monitoring.
Hector C, Keun, Toby J, Athersuch
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Metabonomic Profiling of Bladder Cancer
Journal of Proteome Research, 2014Early diagnosis and life-long surveillance are clinically important to improve the long-term survival of bladder cancer patients. Currently, a noninvasive biomarker that is as sensitive and specific as cystoscopy in detecting bladder tumors is lacking.
Eric Chun Yong, Chan +7 more
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