Chronic opioid treatments dysregulate the glutamatergic system, inducing a hyperglutamatergic state in mesocorticolimbic brain regions. This study investigated the effects of exposure to hydrocodone overdose on locomotor activity, expression of target ...
Woonyen Wong, Youssef Sari
doaj +1 more source
Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long‐term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N‐methyl‐
Katja Naie, Denise Manahan‐Vaughan
openalex +1 more source
GABAB Receptors Mediate Intracellular Calcium Release in Astrocytes of the Prefrontal Cortex
We took advantage of GLAST‐promoter driven GCaMP6s expression in astrocytes to study Ca2+ signaling in astrocytes of the young adult prefrontal cortex in response to GABA with confocal Ca2+ imaging. The results show that GABA induces Ca2+ signaling via the stimulation of the metabotropic GABAB receptor in astrocytes.
Jennifer Bostel+2 more
wiley +1 more source
Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma. [PDF]
Shah R+4 more
europepmc +1 more source
Estrogenic regulation of hippocampal inhibitory system across lifespan
Abstract Estrogens produced in peripheral tissues and locally in the brain are potent neuromodulators. The function of the hippocampus, a brain region essential for episodic memory and spatial navigation, relies on the activity of ensembles of excitatory neurons whose activity is temporally and spatially coordinated by a wide diversity of inhibitory ...
Pablo Méndez+2 more
wiley +1 more source
Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation – Possible role as a dependence receptor [PDF]
Sergey Pshenichkin+5 more
openalex +1 more source
Selective reduction in the expression of type‐1 metabotropic glutamate receptors in the hippocampus of adult rats born by caesarean section [PDF]
Anna Rita Zuena+5 more
openalex +1 more source
AMPA receptor and metabotropic glutamate receptor 1 adaptations in the nucleus accumbens core during incubation of methamphetamine craving. [PDF]
Murray CH+8 more
europepmc +1 more source