Results 91 to 100 of about 52,982 (243)

Modulation of Auditory Cortex Activity in Salicylate‐Induced Tinnitus Rats via Deep Brain Stimulation of the Inferior Colliculus

Brain and Behavior, Volume 15, Issue 9, September 2025.
Deep brain stimulation of the inferior colliculus (ICx) significantly reduces auditory cortex hyperactivity in a rat model of tinnitus. This study highlights ICx stimulation as a promising therapeutic approach for tinnitus‐related neural dysregulation.
Zeinab Akbarnejad, Kasra Bagherian, Seyed Ali Noorbakhsh, Ali Fathi Jouzdani, Saeid Mahmoudian, Marjan Mirsalehi, Maryam Jafarian, Ronak Mohammadi, Alimohamad Asghari, Abdoreza Asadpour   +9 more
wiley   +1 more source

Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery

Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.
The top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Min Su, Huan Qin, Jie Shen, Hao An, Yu Cao   +4 more
wiley   +1 more source

Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses

Clinical and Translational Medicine, Volume 15, Issue 9, September 2025.
Wu et al. studied why certain brain areas are more connected than others. They found that areas with similar protein patterns tend to work together more closely. Additionally, they found when one area is affected such as in brain tumours, other areas with similar patterns especially contralateral regions might help.
Jinsong Wu, Zixian Wang, Fengjiao Li, Shuolei Bu, Lianglong Sun, Chen Zheng, Zhixin Bai, Luhao Yang, Fangyuan Gong, Jiali Chen, Yien Huang, Wanjing Li, Guoquan Yan, Weiwei Xian, Jiaxuan Yang, Shuai Wu, Kemin Zhu, Wenke Fan, Qiong Liu, Guomin Zhou, Gong‐Hong Wei, Wensheng Li, Jing Yan, Jingliang Cheng, Russell G. Snell, Maurice A. Curtis, Tianye Jia, Binke Yuan, Yong He, Weijiang Zhang, Linya You   +30 more
wiley   +1 more source

Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway

Neurobiology of Disease, 2019
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to ameliorate pain and pain-related cognitive impairments by restoring glutamatergic synapses functioning in the spared nerve injury (SNI) of the sciatic nerve
Serena Boccella, Claudia Cristiano, Rosaria Romano, Monica Iannotta, Carmela Belardo, Antonio Farina, Francesca Guida, Fabiana Piscitelli, Enza Palazzo, Mariacristina Mazzitelli, Roberta Imperatore, Lea Tunisi, Vito de Novellis, Luigia Cristino, Vincenzo Di Marzo, Antonio Calignano, Sabatino Maione, Livio Luongo   +17 more
doaj   +1 more source

The mRNA Translation Inhibitor Vioprolide A Prevents Inflammatory Pain‐Like Behaviour With Limited Action on Already Established Pain‐Like Behaviour in Mice

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Background Accumulating evidence indicates that pharmacological inhibition of the translational machinery is a therapeutic strategy for various diseases. However, whether inhibitors of mRNA translation might be suitable for pain therapy remains poorly understood. Here, we tested the potential analgesic effects of the natural product vioprolide
Patrick Engel, Tilman Gross, Gesine Wack, Rekia Sinderwald, Luisa Burgers, Robert Fürst, Achim Schmidtko   +6 more
wiley   +1 more source

MicroRNA (miRNA) in Plasma Small Extracellular Vesicles (sEV) as Potential Early Indicators of Dairy Cow Subfertility

Journal of Extracellular Biology, Volume 4, Issue 9, September 2025.
ABSTRACT Pregnancy and live birth rates are commonly used metrics to define fertility in humans and animals. The impact of aberrant microRNA (miRNA) expression on fertility‐related genes represents a significant knowledge gap in understanding post‐transcriptional regulatory mechanisms associated with reproductive dysfunction.
Pevindu Abeysinghe, Natalie Turner, Holly Flay, Susanne Meier, Leila Cuttle, Murray D. Mitchell   +5 more
wiley   +1 more source

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

Molecules, 2017
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis.
Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang, Jian-Gong Shi, Su-Juan Wang   +13 more
doaj   +1 more source

A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors*

Journal of Biological Chemistry, 2001
Specific domains of the G-protein α subunit have been shown to control coupling to heptahelical receptors. The extreme N and C termini and a region between α4 and α5 helices of the G-protein α subunit are known to determine selective interaction with the
J. Blahoš, T. Fischer, I. Brabet, D. Stauffer, G. Rovelli, J. Bockaert, J. Pin   +6 more
semanticscholar   +1 more source

Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

JOR SPINE, Volume 8, Issue 3, September 2025.
This study explores the role of Central Pattern Generators (CPGs) in locomotor recovery after spinal cord injury (SCI). It examines CPG organization, function, and modulation through amino acids, biogenic amines, and acetylcholine. Therapeutic strategies, including pharmacological, electrical, and optogenetic approaches, are reviewed, alongside current
Hao Su, Longfei Jing, Dongmei Lv, Zhendong Huan, Wenqiang Xu   +4 more
wiley   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source