Results 1 to 10 of about 114,184 (367)
Kinetic fingerprinting of metabotropic glutamate receptors [PDF]
Communications Biology, 2023 FRET and confocal patch-clamp fluorometry in oocytes is used to analyze glutamateinduced conformational changes and dimerization of mGluR 1-8 homo- and heterodimers.
Taulant Kukaj +4 more
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Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]
ASN Neuro, 2012 Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan +3 more
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Metabotropic glutamate receptors in cancer [PDF]
Neuropharmacology, 2017 Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen +3 more
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The Role of Glutamate Receptors in Epilepsy
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
doaj +2 more sources
Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia [PDF]
Mol Pharmacol, 2022 Accumulating evidence of glutamatergic abnormalities in the brains of schizophrenia patients has led to efforts to target various components of glutamatergic signaling as potential new approaches for schizophrenia.
S. Dogra, P. Conn
semanticscholar +2 more sources
Optical control of metabotropic glutamate receptors [PDF]
Nature Neuroscience, 2013 G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Harald Janovjak +13 more
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Role of Metabotropic Glutamate Receptors in Neurological Disorders
Frontiers in Molecular Neuroscience, 2019 Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi +3 more
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Metabotropic Glutamate Receptors for Parkinson's Disease Therapy
Parkinson's Disease, 2013 Excessive glutamatergic signalling within the basal ganglia is implicated in the progression of Parkinson’s disease (PD) and inthe emergence of dyskinesia associated with long-term treatment with L-DOPA.
Fabrizio Gasparini +2 more
doaj +2 more sources
A Review of Molecular Imaging of Glutamate Receptors
Molecules, 2020 Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter ...
Jong-Hoon Kim +3 more
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Targeting metabotropic glutamate receptors for novel treatments of schizophrenia
Molecular Brain, 2017 Support for the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia has led to increasing focus on restoring proper glutamatergic signaling as an approach for treatment of this devastating disease.
James Maksymetz +2 more
doaj +2 more sources