Results 181 to 190 of about 33,548 (283)

Cas12Fold Accurately Predicts Cas12 Nuclease Structures to Enable Structure‐based Genome‐editing Engineering

Small Structures, EarlyView.
Cas12Fold, a deep‐learning framework tailored to Cas12 nucleases, uses evolutionary signals and iterative structure‐based alignment to resolve conformational complexity. This method outperforms general models in predicting key domains and states, accurately modeling enzymes such as Casλ.
Feng Xu, Zilong Zhao, Chang Liu, Meixia Yu, Ke Li, Yilin Jing, Peiyang Li, Beibei Xin, Jian Chen, Lizhu E, Jinsheng Lai, Zhijia Yang, Hainan Zhao   +12 more
wiley   +1 more source

PAIPline: pathogen identification in metagenomic and clinical next generation sequencing samples [PDF]

, 2018
Andreas Andrusch, Piotr Wojciech Dąbrowski, Jeanette Klenner, Simon H. Tausch, Claudia Kohl, Abdalla A. Osman, Bernhard Y. Renard, Andreas Nitsche   +7 more
openalex   +1 more source

Electronic health records improve the diagnosis and prognosis of pulmonary fungal infections in lung cancer patients

VIEW, EarlyView.
Pulmonary fungal infections are life‐threatening complications in lung cancer patients, posing significant challenges in clinical management. To address this, we developed machine learning tools that translate routine electronic health record data into actionable insights for diagnosing infections and assessing prognosis.
Hongwei Meng, Jiayun Yang, Shouzhi Yang, Ayizekeranmu Yiming, Wenjun Yu, Yuewei Zhao, Chunmeng Ding, Kexin Meng, Si Gao, Yang Li, Nan Dan, Dandan Feng, Yunhua Xu, Lin Huang, Yongxia Qiao   +14 more
wiley   +1 more source

The clinical value of metagenomic next-generation sequencing for rapid microbial identification of chronic granulation wound infections

Archives of Medical Science, 2023
Hanhua Li, Xiaoming Zhou, Tao Lui, Rongjie Wu, Zhi-feng Huang, Chuan-wei Sun, Zu-an Liu, Shao-yi Zheng, Wen Lai, Hongming Lou, Bing Xiong   +10 more
doaj   +1 more source

Pediatric Brainstem Encephalitis Outbreak Investigation with Metagenomic Next-Generation Sequencing [PDF]

, 2018
Kristoffer E. Leon, Dídac Casas‐Alba, Akshaya Ramesh, Lillian M. Khan, Cristian Launes, Hannah A. Sample, Kelsey C. Zorn, Ana Valero, Charles Langelier, Carmen Muñoz‐Almagro, Joseph L. DeRisi, Michael R. Wilson   +11 more
openalex   +1 more source

A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

, 2023
Yushan Liu, Gezhi Zheng, Jing Li, Yang Nan, Juan Li, Zhengwen Liu, Qunying Han, Shihua Zhao, Fenjing Du, Yingli He, Taotao Yan   +10 more
openalex   +2 more sources

Postauricular Skin Mycobiome Profiles in Atopic Dermatitis Treated With Dupilumab or Cyclosporine A: A Descriptive Case Series

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) essentially exhibits dysbiosis of skin fungal microbiome, mycobiome, characterized by depletion of Malassezia. The effects of recent systemic therapies for AD on skin mycobiome were not understood enough. We examined changes of skin mycobiome before and after systemic treatments with anti‐IL‐4Rα antibody (dupilumab: DUP)
Yuta Koike, Hitomi Morisaki, Daisuke Motooka, Mai Matsumoto, Motoi Takenaka, Hiroyuki Murota   +5 more
wiley   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

The Diagnostic Value of Metagenomic Next Generation Sequencing in Tuberculosis

Hong Liu, Saiguang Ji, Fuchen Xing, Chenyan Wang, Wei Sun, Hongan Shao, Chunmei Hu   +6 more
openalex   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source