Results 171 to 180 of about 4,937,404 (296)

Cross species metabolic complementation of vitamin K2 biosynthesis determines emergent suppression of tomato Fusarium wilt

open access: yesiMeta, EarlyView.
Multi‐omics approaches have revealed a cross‐species functional emergence phenomenon leading to emergent suppression of Fusarium wilt. We show that a three‑species consortium exhibits emergent suppression of Fusarium oxysporum f. sp. lycopersici (Fol) that is absent in single or pairwise cultures.
Lizhi Zhao   +8 more
wiley   +1 more source

Metagenomic next-generation sequencing to diagnose atypical severe scrub typhus

open access: yesJournal of Microbiology, Immunology and Infection, 2022
Zuan Zhan   +4 more
doaj   +1 more source

Clinical utility of metagenomic next-generation sequencing in infants with severe infections. [PDF]

open access: yesFront Microbiol
Gao Y   +10 more
europepmc   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

open access: yesiNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang   +9 more
wiley   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

open access: yesiNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li   +11 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

open access: yesInterdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li   +7 more
wiley   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

open access: yesInterdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang   +10 more
wiley   +1 more source

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