Results 161 to 170 of about 4,937,404 (296)

Benchmarking gut microbiome indices within and across populations

open access: yesiMetaOmics, EarlyView.
We compared 10 widely used gut microbiome indices in 12,561 American Gut Project participants and 10 external cohorts, testing how well each distinguished people with healthy lifestyles, responded to 79 environmental factors, and associated with 14 chronic conditions. No single index performed best on all three tasks.
Yu Sun   +6 more
wiley   +1 more source

Correction: Unmasking the mimic: vertebral alveolar echinococcosis diagnosed by metagenomic next‑generation sequencing. [PDF]

open access: yesInfection
Kruis T   +7 more
europepmc   +1 more source

Underrecognized Q fever and rickettsial diseases across China

open access: yesiMetaOmics, EarlyView.
Q fever and rickettsial diseases are underrecognized causes of fever of unknown origin in China, with Coxiella burnetii and Orientia tsutsugamushi predominating. We identify Rickettsia bellii‐like sequences in human clinical specimens and highlight unexpected pediatric detections that warrant further investigation of possible exposure patterns ...
Tian Qin   +6 more
wiley   +1 more source

Metagenomic Next-Generation Sequencing of Bronchoalveolar Lavage Fluids Improves Pathogen Detection and Antimicrobial Stewardship in Lower Respiratory Tract Infections: A Retrospective Study

open access: yesInfection and Drug Resistance
Xiangsong Ma,1 Qinqin Zhang,1,2 Xuelian Ji,1 Yun Xia,1 Ju Cao,1 Xiuyu Xu1 1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Laboratory Medicine,
Ma X, Zhang Q, Ji X, Xia Y, Cao J, Xu X
doaj  

Application of metagenomic next-generation sequencing in children with pneumonia of unknown etiology. [PDF]

open access: yesFront Cell Infect Microbiol
Huang H   +7 more
europepmc   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

open access: yesiMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao   +10 more
wiley   +1 more source

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

open access: yesiMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu   +5 more
wiley   +1 more source

Bronchoalveolar Lavage Fluid Metagenomic Second-Generation Sequencing Assists in Guiding the Treatment of Visceral Leishmaniasis: A Case Report [PDF]

open access: yes
Jian Li,1,* Li Liu,2,* Zhiyun Gao,1 Xia Chuai,3 Xiaokun Liu,4 Xiaobo Zhang,2 Xinyu Zhang,2 Xiaoqing Su,2 Qian Xu,2 Zhuojun Deng2 1Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China ...
Liu X   +8 more
core  

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