Results 141 to 150 of about 30,985 (257)

The clinical value of metagenomic next generation sequencing in the diagnosis of non-neutropenic invasive pulmonary aspergillosis. [PDF]

Front Cell Infect Microbiol
Zhong H, Sun C, Lu Y, Cai X, Cao M, Wang L, Feng C, Song M, Sun W, Shi M, Tao Y, Zhou J, Chen C, Lu X, Li Y, Ni Y, Cai Y, Zhong J, Li Y, Wu W, Shi Y, Wang M, Su X.   +22 more
europepmc   +1 more source

Iron/Manganese Oxide‐Bound Nitrogen Suppresses Microbial Mediated Nitrate Reduction in Soil

Land Degradation &Development, EarlyView.
ABSTRACT Nitrogen cycling plays a pivotal role in sustaining ecosystem productivity and stability, while the chemical forms of nitrogen in soils critically influence both its efficiency and pathways. In this study, farmland soils from the Anning River Basin—an important watershed in Southwest China—were investigated to examine the regulatory effects of
Yu Cheng, Xuehao Zheng, Miao Yang, Shoujiang Liu   +3 more
wiley   +1 more source

Enhanced pathogen identification in fungal endophthalmitis by metagenomic next-generation sequencing: a retrospective clinical evaluation. [PDF]

Sci Rep
Zhang X, Li W, Wu H, Cai T, Chen H, Zeng S.   +5 more
europepmc   +1 more source

Carbon‐Fixing Bacterial Network Complexity Mediates Soil Multifunctionality in a Panax notoginseng‐Pinus armandii Agroforestry System

Land Degradation &Development, EarlyView.
ABSTRACT Autotrophic carbon‐fixing bacteria (CFB) are central contributors to soil carbon sequestration and biogeochemical carbon cycling in agroforestry ecosystems and can act as reliable biological indicators for evaluating agroforestry ecosystem sustainability.
Jingying Hei, Rui Rui, Shu Wang, Xiahong He   +3 more
wiley   +1 more source

Case Report: Cervical lymphadenitis resulting from <i>Pseudomonas aeruginosa</i> diagnosed by metagenomic next-generation sequencing. [PDF]

Front Pediatr
Gao L, Wen Y, Jing X.
europepmc   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Diagnostic Value of Metagenomic Next-Generation Sequencing for Suspected Native Spinal Brucella Infection: A Multicenter Study. [PDF]

Neurospine
Li Z, Zhang Q, Wang H, Zhang Z, Liu J, Li L, Lin Y, Wang Y, Yin C, Wang W, Shen F, Han Z, Hao S, Cong P, Tian T, Liu Q, Chen X, Zhan H, Peng T, Yu X, Pu X, Lian X, Wang T.   +22 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Ecosystem retrogression enhances cross‐domain microbial stability and increases the genetic potential for nutrient cycling

mLife, EarlyView.
Abstract Ecosystem retrogression drives nutrient depletion, reduced productivity, and profound reorganization of soil microbial communities. Using amplicon sequencing and genome‐resolved metagenomics, we examined how cross‐domain microbial networks and functional gene potential respond to long‐term phosphorus and nitrogen limitation along the well ...
Javier A. Ceja‐Navarro, Dishant Patel, Garret Genco, Alyssa Byer, Daliang Ning, Kenneth H. Wan, Susan E. Celniker, Jizhong Zhou, Paul Dijkstra, Bruce A. Hungate, Jennifer Pett‐Ridge, Eoin L. Brodie   +11 more
wiley   +1 more source