Results 131 to 140 of about 6,252 (250)

Metagenomics : tools and insights for analyzing next-generation sequencing data derived from biodiversity studies

, 2015
Advances in next-generation sequencing (NGS) have allowed significant breakthroughs in microbial ecology studies. This has led to the rapid expansion of research in the field and the establishment of “metagenomics”, often defined as the analysis of DNA ...
Polymenakou, Paraskevi, Kotoulas, Georgios, loannis Iliopoulos, Arvanitidis, Christos, Pavlopoulos, Georgios A, Papanikolaou, Nikolas, Georgios Kotoulas, Nikolas Papanikolaou, Oulas, Anastasis, Anastasis Oulas, Ioannis Iliopoulos, Christina Pavloudi, Christos Arvanitidis, Paraskevi Polymenakou, Georgios A. Pavlopoulos, Iliopoulos, Ioannis, Pavloudi, Christina   +16 more
core   +1 more source

Metagenomic Next-Generation Sequencing in Clinical Microbiology

Indian Journal of Medical Microbiology, 2019
Jobin John, Jacob, Balaji, Veeraraghavan, Karthick, Vasudevan   +2 more
openaire   +2 more sources

Probiotics‐derived postbiotics improve host metabolic syndrome by activating the adipocyte thermogenic signaling pathway in high‐fat diet‐fed mice

iMetaOmics, EarlyView.
This schematic illustrates how probiotics‐derived postbiotics (PLBK®1–5) combat high‐fat diet‐induced obesity. Postbiotics remodel gut microbiota, boosting beneficial metabolites. These metabolites activate adipocyte thermogenesis (Ucp1/AMPK pathway), resulting in reduced body weight, improved insulin sensitivity, and alleviated hepatic steatosis in ...
Ye Tian, Liujing Huang, Yifan Liu, Xudong Mai, Yanbo Cheng, Bingdong Liu, Yixin Chen, Liwei Xie   +7 more
wiley   +1 more source

Cryptococcus Neoformans Osteomyelitis of the Right Ankle Diagnosed by Metagenomic Next-Generation Sequencing in a HIV-Negative Patient with Tuberculous Lymphadenitis and Pulmonary Tuberculosis: A Case Report and Recent Literature Review

Infection and Drug Resistance
Yao Qin,1 Xingwu Zou,1 Yanghui Jin,2 Jinmeng Li,3 Qingshan Cai1 1Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China; 2Department of Orthopaedic, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China;
Qin Y, Zou X, Jin Y, Li J, Cai Q
doaj  

Clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections in ICU: a multicenter retrospective study

International Journal of Infectious Diseases
Background: Central nervous system (CNS) infections impose a substantial global burden of morbidity and mortality, necessitating accurate and timely diagnosis for optimal clinical management.
Jian Liu, Yongquan Dong, Yuanxiu Huang, Mengxiao Xie, Hongyu Wang, Qianqian Wang, Shengfeng Wang, Nan Wang, Yongpo Jiang, Wenxiao Zhang, Mingqiang Wang, Jian Chen, Lingtong Huang, Hongliu Cai   +13 more
doaj   +1 more source

Clinical Application of Metagenomic Next-Generation Sequencing (mNGS) in Patients with Early Pulmonary Infection After Liver Transplantation

Hua-Bin Peng,1 Ying Liu,1 Fei Hou,1 Shuang Zhao,1 Yi-Zhi Zhang,1 Zhi-Ying He,1 Jing-Yi Liu,1 Hao-Feng Xiong,1 Li-Ying Sun1– 4 1Department of Critical Liver Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of ...
Zhang YZ, Liu Y, Zhao S, Sun LY, Peng HB, He ZY, Liu JY, Xiong HF, Hou F   +8 more
core  

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure

Metagenomic high-throughput sequencing (mHTS) is a hypothesis-free, universal pathogen detection technique for determination of the DNA/RNA sequences in a variety of sample types and infectious syndromes.
De Vries, Jute J. C., López Labrador, F. Xavier, ESCV Network on Next-Generation Sequencing, Leuzinger, Karoline   +3 more
core   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

L‐EasyARG: A long‐read metagenomics tool for rapid antibiotic‐resistance‐gene profiling

iMetaOmics, EarlyView.
L‐EasyARG is a pipeline for long‐read metagenomic profiling of antibiotic resistance genes (ARGs) and their genetic context. It integrates ARG identification, plasmid and mobile genetic element (MGE) detection, taxonomic classification, and further identifies ARGs carried by human bacterial pathogens (HBPs) defined in the WHO and ESKAPE pathogen lists.
Yongxin Li, Mingchao Wang, Xiaohui Liu, Junhua Wu, Yujie Mao, Caili Zhang, Qingru Chen, Zhi Wang, Gongchao Jing, Maozhen Han   +9 more
wiley   +1 more source