Results 111 to 120 of about 4,937,404 (296)

Effects of Dietary Mannan Oligosaccharides on Growth, Disease Resistance, and Gut Microbiota in Zebrafish

Animal Research and One Health, EarlyView.
Supplementation with mannan oligosaccharides (MOS) enhances growth, disease resistance, antioxidant capacity, and gut microbiota diversity while suppressing inflammation, apoptosis, and strengthening intestinal barrier integrity in zebrafish challenged with LPS or DSS.
Zhiyuan Lu, Longjiang Tang, Lei Deng, Ziheng Ren, Zhiyuan Gong   +4 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Metagenomic next‐generation sequencing in the early diagnosis of leptospirosis infection presenting as acalculous cholecystitis and septic shock in a non‐epidemic area after typhoons: A case report

Clinical Case Reports
Key Clinical Message Leptospirosis is an important zoonosis worldwide. Due to nonspecific clinical manifestation and poor recognition in non‐epidemic area, there is often a delay in diagnosis and treatment.
Xueying Han, Bihan Huang, Lilei Yang, Jinglan Wu, Haigang Zhang   +4 more
doaj   +1 more source

Clinical Application of Metagenomic Next-Generation Sequencing (mNGS) in Patients with Early Pulmonary Infection After Liver Transplantation [PDF]

Hua-Bin Peng,1 Ying Liu,1 Fei Hou,1 Shuang Zhao,1 Yi-Zhi Zhang,1 Zhi-Ying He,1 Jing-Yi Liu,1 Hao-Feng Xiong,1 Li-Ying Sun1– 4 1Department of Critical Liver Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of ...
Zhang YZ, Liu Y, Zhao S, Sun LY, Peng HB, He ZY, Liu JY, Xiong HF, Hou F   +8 more
core  

Unmasking the mimic: vertebral alveolar echinococcosis diagnosed by metagenomic next-generation sequencing [PDF]

A Siberian woman in her forties presented to a public hospital in northeastern Germany with chronic back pain and a paravertebral mass, initially misdiagnosed as spinal tuberculosis.
Kruis, Tassilo, Lührig, Katharina, Ziegler, Johannes, Wassermann, Marion, Graf, Barbara, Isner, Caroline, Menzel, Peter, Schwarzer, Rolf   +7 more
core   +1 more source

AR: An Artificial Intelligence‐Driven Fluorescent Reporter System for Gene Editing Evaluation

Animal Research and One Health, EarlyView.
The AR platform integrates an enhanced dual‐fluorescence reporter with the EasyReporter AI pipeline for efficient gene‐editing evaluation. It enables automated, high‐throughput quantification and intelligent interpretation across diverse gene‐editing systems and cellular contexts. The gene‐editing elements were created with BioGDP.com.
Mingming Xue, Hanhan Li, Yuwan Zheng, Hezhen Yang, Pengsheng Dong, Hang Jiao, Junhao Zhang, Genyuan Li, Ziyao Zhu, Hongjiang Li, Miao Zhang, Zhiquan Wang, Baosheng Feng, Qunting Lin, Guoying Hua, Kejun Wang, Wenting Li, Xiangtao Kang   +17 more
wiley   +1 more source

Optimizing Splicing Junction Detection in Next Generation Sequencing Data on a Virtual-GRID Infrastructure [PDF]

, 2012
The new protocol for sequencing the messenger RNA in a cell, named RNA-seq produce millions of short sequence fragments. Next Generation Sequencing technology allows more accurate analysis but increase needs in term of computational resources. This paper
Provenzano, R., Provenzano R., Terzo, Olivier, Mossucca, L., Acquaviva, Andrea, Ficarra, Elisa, Mossucca L, Abate, Francesco   +7 more
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Fecal Virome Transplantation in Human Disease and Livestock Production: Evidence, Mechanisms, and Translational Challenges

Animal Research and One Health, EarlyView.
Fecal virome transplantation may reshape bacterial communities and host responses while reducing viable bacterial transfer. Preclinical evidence suggests biological activity, but human efficacy remains uncertain, and translation requires product standardization, causal validation, donor–recipient matching, and rigorous biosafety assessment.
Luanyang Shi, Yongjuan Guan, Guanxiang Liang   +2 more
wiley   +1 more source

Unravelling the enigma of the human microbiome: Evolution and selection of sequencing technologies

Microbial Biotechnology
The human microbiome plays a crucial role in maintaining health, with advances in high‐throughput sequencing technology and reduced sequencing costs triggering a surge in microbiome research.
Xin Yi, Hong Lu, Xiang Liu, Junyi He, Bing Li, Zhelong Wang, Yujing Zhao, Xinri Zhang, Xiao Yu   +8 more
doaj   +1 more source

Symposium NGS 2016 - ‘Next generation sequencing’ technology in routine analysis in Belgian healthcare system (EN)

, 2016
‘Next generation sequencing’ technology in routine analysis in Belgian healthcare system.
M. Van den Bulcke
core