Results 101 to 110 of about 6,252 (250)

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

MOESM2 of Metagenomic next-generation sequencing for mixed pulmonary infection diagnosis

, 2019
Additional file 2: Table S1. Patients for metagenomic next-generation sequencing (mNGS) and conventional laboratory-based diagnostic ...
Jiahui Wang (746367), Jing Feng (177843), Yelei Han (8159838)   +2 more
core   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Metagenomic next‐generation sequencing in the early diagnosis of leptospirosis infection presenting as acalculous cholecystitis and septic shock in a non‐epidemic area after typhoons: A case report

Clinical Case Reports
Key Clinical Message Leptospirosis is an important zoonosis worldwide. Due to nonspecific clinical manifestation and poor recognition in non‐epidemic area, there is often a delay in diagnosis and treatment.
Xueying Han, Bihan Huang, Lilei Yang, Jinglan Wu, Haigang Zhang   +4 more
doaj   +1 more source

Metagenetic analysis of patterns of distribution and diversity of marine meiobenthic eukaryotes [PDF]

, 2014
Aim:Meiofaunal communities that inhabit the marine benthos offer unique opportunities to simultaneously study the macroecology of numerous phyla that exhibit different life-history strategies.
Quince, Christopher, Christopher Quince, John D. Lambshead, Fonseca, V.G., Harriet F. Johnson, Power, Deborah M., W. Kelley Thomas, Nichols, B., Quince, C., Fonseca, Vera G., Creer, Simon, Simon P. Neill, Nichols, Ben, Lambshead, John D., Simon Creer, Thomas, W. Kelley, Deborah M. Power, Neill, S.P., Creer, S., Johnson, H.F., Lambshead, J.D., Johnson, Harriet F., Power, D.M., Ben Nichols, Vera G. Fonseca, Gary R. Carvalho, Carvalho, Gary R., Carvalho, G.R., Neill, Simon P., Thomas, W.K.   +29 more
core   +1 more source

Binning and annotation for metagenomic next-generation sequencing reads

, 2015
The development of next-generation sequencing technology enables us to obtain a vast number of short reads from metagenomic samples. In metagenomic samples, the reads from different species are mixed together. So, metagenomic binning has been introduced to cluster reads from the same or closely related species and metagenomic annotation is introduced ...
openaire   +3 more sources

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Inverse sky islands: lowland river valleys drive microbial divergence while high elevations select for convergence in massive mountain ecosystems

Ecography, EarlyView.
Mountain ecosystems are often interpreted through the lens of the ‘sky island' model, where high‐elevation habitats function as isolated archipelagos. However, this model's applicability to massive, topographically complex mountain ranges where highlands are continuous and lowlands are fragmented remains untested.
Yazhou Zhang, J. Aaron Hogan, Jianjun Wang, Wenguang Sun, Yaojun Ye, Xin Liu, Minshu Song, Hang Sun   +7 more
wiley   +1 more source

Unravelling the enigma of the human microbiome: Evolution and selection of sequencing technologies

Microbial Biotechnology
The human microbiome plays a crucial role in maintaining health, with advances in high‐throughput sequencing technology and reduced sequencing costs triggering a surge in microbiome research.
Xin Yi, Hong Lu, Xiang Liu, Junyi He, Bing Li, Zhelong Wang, Yujing Zhao, Xinri Zhang, Xiao Yu   +8 more
doaj   +1 more source