Results 81 to 90 of about 58,932 (285)

Deconvolute individual genomes from metagenome sequences through short read clustering. [PDF]

, 2020
Metagenome assembly from short next-generation sequencing data is a challenging process due to its large scale and computational complexity. Clustering short reads by species before assembly offers a unique opportunity for parallel downstream assembly of
Deng, Li, Li, Kexue, Lu, Yakang, Shi, Lizhen, Wang, Lili, Wang, Zhong   +5 more
core  

Q Fever-Related Glomerulonephritis Unveiled by Metagenomic Next-Generation Sequencing

Kidney International Reports
Yang Li, Yueping Shen, Hongyu Yang, Min Li, Lei Jiang, Wei Ma, Fude Zhou, Tao Su   +7 more
doaj   +3 more sources

Comparison of metagenomic samples using sequence signatures [PDF]

, 2012
BACKGROUND: Sequence signatures, as defined by the frequencies of k-tuples (or k-mers, k-grams), have been used extensively to compare genomic sequences of individual organisms, to identify cis-regulatory modules, and to study the evolution of regulatory
Bai Jiang, Fengzhu Sun, Jie Ren, Kai Song, Minghua Deng, Xuegong Zhang   +5 more
core   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

The unseen world: environmental microbial sequencing and identification methods for ecologists [PDF]

, 2014
Archaea, bacteria, microeukaryotes, and the viruses that infect them (collectively “microorganisms”) are foundational components of all ecosystems, inhabiting almost every imaginable environment and comprising the majority of the planet’s organismal and ...
Aronson, Emma, Izard, Jacques, Klatt, Christian, Zhou, Jizhong, Zimmerman, Naupaka   +4 more
core   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases

BMC Infectious Diseases, 2021
Background Although traditional diagnostic techniques of infection are mature and price favorable at present, most of them are time-consuming and with a low positivity.
Hongxia Duan, Xuan Li, Aihong Mei, Ping Li, Yang Liu, Xiaofeng Li, Weiwei Li, Changhui Wang, Shuanshuan Xie   +8 more
doaj   +1 more source

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. [PDF]

, 2019
Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens ...
Byaruhanga, Oswald, de Bourcy, Charles, DeRisi, Joseph L, Dimitrov, Boris, Egger, Rebecca, Hsu, Jennifer, Juan, Yun-Fang, Kalantar, Katrina, Kyohere, Mary, Langelier, Charles, Mpimbaza, Arthur, Nakielny, Sara, Ramesh, Akshaya, Rosenthal, Philip J, Ruel, Theodore, Sheu, Jonathan, Wang, James, Wilson, Michael R   +17 more
core   +3 more sources

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Metagenomic analysis of dental calculus in ancient Egyptian baboons [PDF]

, 2019
Dental calculus, or mineralized plaque, represents a record of ancient biomolecules and food residues. Recently, ancient metagenomics made it possible to unlock the wealth of microbial and dietary information of dental calculus to reconstruct oral ...
Bramanti, Barbara, Guellil, Meriam, Kersten, Oliver, Ottoni, Claudio, Ozga, Andrew T, Porcier, Stéphanie, Stone, Anne C, Van Neer, Wim   +7 more
core   +1 more source