Results 1 to 10 of about 699 (152)

Functionalizing Injectable Hydrogels with Cobalt-Based Metallacarboranes for Targeted Delivery in Triple-Negative Breast Cancer. [PDF]

Chembiochem
This study reports a biocompatible HA–lysine hydrogel loaded with cobalt metallacarborane (CoSAN) for targeted release into triple‐negative breast cancer cells. The system maintains CoSAN cytotoxicity, as confirmed by cell assays and imaging, representing an attractive approach toward a localised TNBC treatment.
Murphy N, González-Gómez R, Ashok N, O'Connell E, Fearnhead H, Tipping WJ, Faulds K, Tong W, Pandit A, Dwyer RM, Graham D, Farràs P.   +11 more
europepmc   +6 more sources

Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands [PDF]

Molecules, 2023
The exploitation of metallacarboranes’ potential in various fields of research and practical applications requires the availability of convenient and versatile methods for their functionalization with various functional moieties and/or linkers of ...
Krzysztof Śmiałkowski, Carla Sardo, Zbigniew J. Leśnikowski   +2 more
doaj   +2 more sources

Zinc Metallacarborane Chemistry. [PDF]

Inorg Chem
This work presents a new family of zincacarborane complexes synthesized from ZnMe2 and [C2B9H13], using neutral two-electron donor ligands: N-heterocyclic carbenes (NHCs) yield the first closo-12-vertex half-sandwich zincocenes, [(NHC)Zn(C2B9H11)] (1-3), while bulkier NHCs form slipped bis-dicarbollide salts (4-5).
Flanagan KR, Johnson CL, Goodall JC, McMullin CL, Johnson AL.   +4 more
europepmc   +3 more sources

Synthesis of Bis(Carboranyl)amides 1,1′-μ-(CH₂NH(O)C(CH₂)_n-1,2-C₂B₁₀H₁₁)₂ (n = 0, 1) and Attempt of Synthesis of Gadolinium Bis(Dicarbollide) [PDF]

Molecules, 2021
Bis(carboranyl)amides 1,1′-μ-(CH2NH(O)C(CH2)n-1,2-C2B10H11)2 (n = 0, 1) were prepared by the reactions of the corresponding carboranyl acyl chlorides with ethylenediamine.
Yasunobu Asawa, Aleksandra V. Arsent’eva, Sergey A. Anufriev, Alexei A. Anisimov, Kyrill Yu. Suponitsky, Oleg A. Filippov, Hiroyuki Nakamura, Igor B. Sivaev   +7 more
doaj   +2 more sources

Boron in Diet and Medicine: Mechanisms of Delivery and Detection [PDF]

Pharmaceuticals
Boron is a trace element with multifaceted chemical and biological properties that underpin its emerging relevance in human health and medicinal chemistry.
Dorota Bartusik-Aebisher, Izabela Rudy, Kacper Rogóż, David Aebisher, Gabriela Henrykowska   +4 more
doaj   +2 more sources

Stabilizing Anion–Anion Aggregates via Dihydrogen Bonds in Non‐Classical Inorganic Molecules

Aggregate
Coulomb's law predicts that like‐charge ions repel and avoid dimerization. However, a class of dimers between like‐charge ions is characterized. The [3,3’‐Fe(1,2‐C2B9H11)2]− (abbreviated as [o‐FESAN]−) represents an innovative non‐classical inorganic ...
Adnana Zaulet, Miquel Nuez‐Martinez, Pipsa Hirva, Reijo Sillanpää, Francesc Teixidor, Clara Viñas   +5 more
doaj   +2 more sources

Synthesis of Polyhedral Borane Cluster Fused Heterocycles via Transition Metal Catalyzed B-H Activation [PDF]

Molecules, 2020
Aromatic heterocycles are ubiquitous building blocks in bioactive natural products, pharmaceutical and agrochemical industries. Accordingly, the carborane-fused heterocycles would be potential candidates in drug discovery, nanomaterials ...
Ke Cao, Cai-Yan Zhang, Tao-Tao Xu, Ji Wu, Xin-Yu Wen, Wen-Jun Jiang, Mao Chen, Junxiao Yang   +7 more
doaj   +2 more sources

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy. [PDF]

Precis Radiat Oncol
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chen C, Yang M, Wang J, Zhang L, Huang S, Xu X, Liu Y.   +6 more
europepmc   +2 more sources

Fe/⁵⁷Fe-Metallacarboranes with Radiosensitizing Potential in Breast Cancer Cell Models: Comparative Study Between High- (⁶⁰Co) and Low-Energy (⁵⁷Co) Gamma Radiation Sources [PDF]

Pharmaceutics
Background: Radiosensitizers can be used to enhance tumor response and mitigate toxicity in healthy tissues during radiation therapy. This study investigates the radiosensitizing potential of the metallacarborane Fe/57Fe-ferrabisdicarbollide in SK-BR-3 ...
Salvatore Di Maria, Diogo M. Engrácia, Catarina I. G. Pinto, João C. Waerenborgh, Bruno J. C. Vieira, Pedro Santos, Teresa Pinheiro, Miquel Nuez-Martínez, António P. Matos, Filipa Mendes, Francesc Teixidor, Clara Viñas, Fernanda Marques   +12 more
doaj   +2 more sources

Assessment of Carrier-Free Metallacarboranes for Targeted Radiation Therapies PBFT and BNCT: Comparative Cellular Effects and Dosimetry Studies with [o-FESAN]⁻ in Breast Cancer Cells [PDF]

Pharmaceuticals
Background: Ferrabis(dicarbollide) ([o-FESAN]−) in combination with proton–boron fusion therapy (PBFT) or boron neutron capture therapy (BNCT) are promising alternative radiation modalities for the treatment of breast cancer. The aim of this study was to
Salvatore Di Maria, Teresa Pinheiro, Luís Cerqueira Alves, Valeria Bitonto, Nicoletta Protti, Simonetta Geninatti Crich, Kai Nishimura, Hiroyuki Nakamura, António P. Matos, Catarina I. G. Pinto, Filipa Mendes, Francesc Teixidor, Clara Viñas, Fernanda Marques   +13 more
doaj   +2 more sources