Results 101 to 110 of about 905,435 (191)

Distribution of Extended-spectrum β-lactamase and Metallo-β-lactamase-producing Pseudomonas aeruginosa in Tertiary Care Hospitals of Lahore, Pakistan [PDF]

, 2019
Background: Pseudomonas aeruginosa (P. aeruginosa) is an important bacterial pathogen most frequently associated with nosocomial infections, especially in immuno-compromised patients.
Aneela, Syeda, Riaz, Saba, Saeed, Muhammad, ul-Ain, Noor-, Hussain, Shahida, Hannan, Abdul, Abrar, Samyyia   +6 more
core   +1 more source

Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.

PLoS ONE, 2011
The New Delhi Metallo-β-lactamase (NDM-1) gene makes multiple pathogenic microorganisms resistant to all known β-lactam antibiotics. The rapid emergence of NDM-1 has been linked to mobile plasmids that move between different strains resulting in world ...
Youngchang Kim, Christine Tesar, Joseph Mire, Robert Jedrzejczak, Andrew Binkowski, Gyorgy Babnigg, James Sacchettini, Andrzej Joachimiak   +7 more
doaj   +1 more source

Prediction of Antibiotic Influence by Presence of Some β-lactamase Gene in AcinetobacterInfected Patients Hospitalized in Tehran, Iran [PDF]

Acinetobacter baumannii which is gram-negative rod and infecting hospitalized patient often develops multiple drug resistance patterns and causes serious problem in treatment.
نیاکان, محمد, یادگاری نیا, داوود, دادگر پاکدل, فاطمه, اکبری, مهدی, کاظمی, سهیلا, امانی, فیروز, رسولی, ایرج, آقابزرگی, سهراب, دادگر پاکدل, جواد   +8 more
core   +1 more source

Horizontal transfer of antibiotic resistance genes on abiotic touch surfaces: implications for public health

, 2012
Horizontal gene transfer (HGT) is largely responsible for increasing incidence of antibiotic-resistant infections worldwide. Whilst studies have focussed on HGT in vivo, this work investigates whether the ability of pathogens to persist in the ...
Warnes, S.L., Sarah L. Warnes, C. William Keevil, Callum J. Highmore, Keevil, C.W., Highmore, C.J.   +5 more
core   +1 more source

Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

Antibiotics, 2014
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able
María-Rocío Meini, Leticia I. Llarrull, Alejandro J. Vila   +2 more
doaj   +1 more source

Study of Metallo β- lactamase producing Pseudomonas aeruginosa in diabetic foot infections [PDF]

, 2015
Introduction: Pseudomonas aeruginosa , gram negative aerobic rod, is an opportunistic and worrisome nosocomial pathogen. Metallo β- lactamase (MBL) mediated resistance to carbapenems is an emerging threat.
Sunildatta Jog, Anjali
core   +1 more source

Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM

Frontiers in Microbiology
Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xinhui Li, Jisheng Zhang, Jianmin Wang, Wenzhang Long, Xushan Liang, Yang Yang, Xue Gong, Jie Li, Longjin Liu, Xiaoli Zhang   +9 more
doaj   +1 more source

A STUDY OF METALLO-BETA-LACTATAMASE PRODUCING PSEUDOMONAS AERUGINOSA IN CLINICAL SAMPLES OF S.S.G. HOSPITAL

National Journal of Medical Research, 2011
Introduction: Pseudomonas spp. is common pathogen causing nosocomial infection. Acquired drug resistance is frequent in nosocomial isolates of Pseudomonas spp. Acquired metallo-β-lactamases (MBL) in pseudomonas spp.
Mehul S Chaudhari, Tanuja B Javadekar, Govind Ninama, Govind Ninama, Jivraj Damor   +4 more
doaj  

A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases.

PLoS ONE, 2019
The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their ...
Nazmul H Khan, Anthony A Bui, Yang Xiao, R Bryan Sutton, Robert W Shaw, Benjamin J Wylie, Michael P Latham   +6 more
doaj   +1 more source

The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

Engineering
This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum activity against ...
Zhuoren Ling, Alistair James Macdonald Farley, Aditya Lankapalli, Yanfang Zhang, Shonnette Premchand-Branker, Kate Cook, Andrei Baran, Charlotte Gray-Hammerton, Claudia Orbegozo Rubio, Edgars Suna, Jordan Mathias, Jürgen Brem, Kirsty Sands, Maria Nieto-Rosado, Maria Mykolaivna Trush, Nadira Naznin Rakhi, Willames Martins, Yuqing Zhou, Christopher Joseph Schofield, Timothy Walsh   +19 more
doaj   +1 more source