Results 141 to 150 of about 52,332 (219)

The Metallo-β-lactamase GOB Is a Mono-Zn(II) Enzyme with a Novel Active Site [PDF]

, 2007
Metallo-β-lactamases (MβLs) are zinc-dependent enzymes able to hydrolyze and inactivate most β-lactam antibiotics. The large diversity of active site structures and metal content among MβLs from different sources has limited the design of a pan-MβL ...
Bennett, Brian, Carloni, Paolo, Costello, Alison L., Gonzalez, Javier M., Limansky, Adriana S., Lisa, Mariá Natalia, Morrán-Barrio, Jorgelina, Peraro, Matteo Dal, Tierney, David L., Viale, Alejandro M., Vila, Alejandro J.   +10 more
core   +1 more source

Motion of the Zinc Ions in Catalysis by a Dizinc Metallo-β-Lactamase [PDF]

, 2009
We report rapid-freeze-quench X-ray absorption spectroscopy of a dizinc metallo-β-lactamase (MβL) reaction intermediate. The Zn(II) ions in the dinuclear active site of the S.
Bennett, Brian, Breece, Robert M., Crowder, Michael W., Hu, Zhenxin, Tierney, David L.   +4 more
core   +2 more sources

Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo‐β‐Lactamases

ChemMedChem, 2019
New Delhi metallo‐β‐lactamase‐1 (NDM‐1) poses an immediate threat to our most effective and widely prescribed drugs, the β‐lactam‐containing class of antibiotics.
Allie Y Chen, P. Thomas, Zishuo Cheng, Nasa Y Xu, D. Tierney, M. Crowder, W. Fast, Seth M. Cohen   +7 more
semanticscholar   +1 more source

Multidrug-resistant Pseudomonas aeruginosa: an endemic problem in Brazil [PDF]

, 2011
Relatos mundiais têm documentado a problemática da endemicidade de isolados clínicos de Pseudomonas aeruginosa multirresistente (MDR) aliada a elevados índices de morbidade/mortalidade. No Brasil, surtos de infecção ocasionados por P. aeruginosa têm sido
LEVY, Carlos E., LINCOPAN, Nilton, MAMIZUKA, Elsa M., NEVES, Patrícia R.   +3 more
core   +2 more sources

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Scientific Reports, 2017
β-Lactamases (BLs) able to hydrolyze β-lactam antibiotics and more importantly the last resort carbapenems, represent a major mechanism of resistance in Gram-negative bacteria showing multi-drug or extensively drug resistant phenotypes.
M. Santucci, F. Spyrakis, S. Cross, A. Quotadamo, D. Fariña, D. Tondi, F. De Luca, J. Docquier, Ana Isabel Prieto, C. Ibacache, J. Blázquez, A. Venturelli, G. Cruciani, Maria Paola Costi   +13 more
semanticscholar   +1 more source

Experimental Evidence for a Metallohydrolase Mechanism in Which the Nucleophile Is Not Delivered by a Metal Ion: EPR Spectrokinetic and Structural Studies of Aminopeptidase from \u3cem\u3eVibrio proteolyticus\u3c/em\u3e [PDF]

, 2007
Metallohydrolases catalyse some of the most important reactions in biology and are targets for numerous chemotherapeutic agents designed to combat bacterial infectivity, antibiotic resistance, HIV infectivity, tumour growth, angiogenesis and immune ...
Bennett, Brian, Kim, Jung Ja, Kittell, Aaron W., Kumar, Amit, Periyannan, Gopal R.   +4 more
core   +1 more source

Post-Transplant Fecal Carriage of Antibiotic Resistant and β-Lactamases-Producing Enterobacteriales among Renal Transplant Recipients

Journal of Nepal Health Research Council
Background: The intestinal colonization and transmission of antibiotic-resistant Enterobacteriales to renal transplant recipients may pose a threat to them because they are profoundly immunocompromised and vulnerable to infection.
Bindira Joshi, Santosh Kumar Yadav, Manju Shree Shakya Hada, Sabina Shrestha, Kalpana Kumari Shrestha, Pukar Chandra Shrestha, Bal Krishna Awal   +6 more
doaj   +1 more source

An overview of the production of AmpC and Metallo-β-Lactamase enzymes in Escherichia coli [PDF]

Medical Laboratory Journal
Escherichia coli is a Gram-negative, rod-shaped bacterium, responsible for 90% of all community-acquired infections and 50% of hospital-acquired infections, with opportunistic infections found in intensive care unit (ICU) patients.
Kirandeep Kaur
doaj  

The role of aztreonam in rational antibacterial therapy of resistant nosocomial gram-negative infections. The new life for a well-known β-lactam

Медицина неотложных состояний
Background. The situation regarding the prevalence of resistant pathogens, types of β-lactamase products, and, accordingly, the justification of rational approaches to antibacterial therapy in Ukraine remains insufficiently studied.
V.A. Korsunov, M.A. Georgiyants, N.I. Zozulia, I.Yu. Odynets, M.B. Pushkar, M.V. Lyzogub, N.M. Bohuslavska, O.L. Onikiienko   +7 more
doaj   +1 more source

Mechanisms of carbapenem resistance in Acinetobacter baumannii [PDF]

, 2009
Pripadnici roda Acinetobacter su nefermentativni mikroorganizmi široko rasprostranjeni u vodi i na zemlji. Pojedine vrste unutar roda sastavni su dio fiziološke flore kože i sluznica te su sposobni preživjeti duži vremenski period na suhim i vlažnim ...
Ivana Goić-Barišić
core   +1 more source