Results 81 to 90 of about 10,865 (201)

Contrasting Effects of HT‐2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
HT‐2 toxin triggers chondrocyte damage and matrix metabolism disorders in KBD via suppressing ZIP6. ZIP6 knockdown alleviates these dysfunctions through FoxO, cAMP and TNF pathways, clarifying the molecular mechanism of cartilage injury. ABSTRACT Kashin‐Beck disease (KBD) is a chronic, endemic osteoarticular disorder associated with T‐2 toxin exposure,
Yang Liu, Yu Zhang, Ruitian Huang, Lulu Bai, Lian Liu, Chaowei Wang, Yirong Qin, Hui Wang, Xiong Guo, Xi Wang, Yujie Ning   +10 more
wiley   +1 more source

ENZYMATIC HYDROGEN BIOPRODUCTION. STRUCTURE, FUNCTION AND APPLICATION OF HYDROGENASES [PDF]

Postępy Mikrobiologii, 2021
Małgorzata Witkowska, Agnieszka Żylicz-Stachula, Anna Struck   +2 more
doaj   +1 more source

Azurins With Tunable Reduction Potentials as Redox Mediators for Extracellular Electron Transfer

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Electroactive microbe Shewanella oneidensis reduced non‐native electron transfer protein, azurin, via extracellular electron transfer (EET) with dependence on azurin redox potential. Utilizing azurin in EET‐driven bio‐(electro)catalysis improved fuel cell current and accelerated textile dye decolorization.
Alexis J. Holwerda, Jing‐Xiang Wang, Yang Gao, Yi Lu, Benjamin K. Keitz   +4 more
wiley   +1 more source

A Non‐Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]‐Hydrogenase Maturation

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Bridged or not? 57Fe NRVS reveals a non‐covalent, electronically coupled interaction between the HydF [4Fe–4S] cluster and the [2Fe] precursor. Boltz‐2 structure predictions suggest that the cubane organizes lipoate‐dependent Hmet chemistry, positioning intermediates for assembly of the CH2–NH–CH2 bridge during H‐cluster biosynthesis.
Giorgio Caserta, Princess R. Cabotaje, Armel T. Waffo, Deepak Prajapat, Ilya Sergueev, Stefan Frielingsdorf, Gustav Berggren   +6 more
wiley   +2 more sources

Sultams as Dual Inhibitors of Human Carbonic Anhydrase and Thioredoxin Reductase

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
A series of sultam‐based N‐acyl derivatives with potential applications as dual TrxR1 and CA inhibitors were synthesized and evaluated. TrxR1 screening identified several active compounds, with inhibitory potency influenced by the type and orientation of substituents.
Aleksandrs Pustenko, Raitis Bobrovs, Venkatesan Saravanan, Kathir Avan, Simone Carradori, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +8 more
wiley   +1 more source

1‐Aryl‐6,7‐Dimethoxy‐3,4‐Dihydroisoquinoline‐2(1H)‐Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Experimental and theoretical studies have disclosed the more relevant structural requirements for effective inhibition and an impressing selectivity toward tumor‐expressed hCA XII isoform over hCA II. Human carbonic anhydrase XII (hCA XII) represents an important pharmacological target for different types of cancer.
Federico Ricci, Anna Di Fiore, Andrea Angeli, Laura De Luca, Francesca Mancuso, Davide Esposito, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto   +8 more
wiley   +1 more source

Novel Inhibitors of Carbonic Anhydrase I and II Identified by High Throughput Virtual Screening and Validated by X‐Ray Crystallography

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
High‐throughput virtual screening identifies novel carbonic anhydrase II ligands from large chemical libraries, enabling rapid hit discovery. Structural validation by X‐ray crystallography confirms the predicted binding modes and reveals key protein–ligand interactions.
Asher L. Brandt, Joseph Venditto, Marta Ferraroni, Claudiu T. Supuran, Andrea Angeli   +4 more
wiley   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Acquired Zinc Deficiency in Preterm Infant Post-Surgery for Necrotizing Enterocolitis (NEC) on Prolonged Total Parenteral Nutrition (TPN)

Pediatric Reports
Zinc (Zn) is a vital trace element that plays a pivotal role in protein synthesis, cellular growth, and differentiation and is involved as a cofactor of metalloenzymes, performing a wide variety of metabolic, immune, and synthesis roles.
Mansour Al Qurashi, Hadeel Mohammad, Syed Sameer Aga, Ahmed Mustafa, Jubara Alallah, Mohammed Al Hindi, Mohammed Al Harbi, Mohammed Hasosah   +7 more
doaj   +1 more source