Results 91 to 100 of about 10,865 (201)

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

Crystal Structures and Magnetic Properties of Coordination Polymer Complexes of Metal Ions With Kojic Acid Ligands

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 10, 7 July 2026.
One‐dimensional coordination polymers of Cu(II) and Co(II) with kojic acid show distinct chain connectivities revealed by X ray crystallography and exhibit extremely weak magnetic interactions, as supported by magnetic measurements and molecular orbital calculations. The crystal structures and magnetic properties of coordination complexes [Cu(C6H5O4)2]
Wataru Fujita, Tomoko Yamaguchi
wiley   +1 more source

Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase

IUCrJ
Copper-containing nitrite reductases (CuNiRs) catalyse the reduction of nitrite to nitric oxide and are a key enzyme in the anaerobic ammonium oxidation and denitrification steps of the nitrogen cycle.
Nopphon Petchyam, Allegra Mbouku, Robert R. Eady, S. Samar Hasnain, Svetlana V. Antonyuk   +4 more
doaj   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science
Herpes simplex viruses (HSV‐1 and HSV‐2) are highly prevalent and contagious, causing lifelong infections that cannot be eradicated with current therapies.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
doaj   +1 more source

Metalloenzyme [PDF]

, 2017
D. Meißner, T. Arndt
openaire   +1 more source

Inactivation of metalloenzymes by salicylate [PDF]

FEBS Letters, 1970
Grisolia, S., Mèndelson, J., Diederich, D.   +2 more
openaire   +2 more sources

Energy-Screened Many-Body Expansion for Protein-Ligand Interactions: Examining Convergence for Metalloenzymes Through Seven-Body Interactions. [PDF]

J Chem Theory Comput
Bowling PE, Broderick DR, Herbert JM.
europepmc   +1 more source

Tracking the redox reaction of the iron enzyme ribonucleotide reductase using continuous SerialED and SFX. [PDF]

Structure
Pacoste L, Kumar R, Srinivas V, Makita H, Simon PS, Bannerjee R, Minnetian NM, Bhowmick A, Paley DW, Mittan-Moreau DW, Chatterjee K, Rosenberg DJ, Batyuk A, Gee LB, Alonso-Mori R, Sauter NK, Yano J, Yachandra VK, John J, Aurelius O, Brewster AS, Kern JF, Blomberg B, Lebrette H, Xu H, Hofer G, Högbom M, Zou X.   +27 more
europepmc   +1 more source

Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. [PDF]

Chem Sci
Yu J, Wang C, Hu W, Wang H, Zhao J, Pan HJ.   +5 more
europepmc   +1 more source