Results 91 to 100 of about 11,336 (207)

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

A Variant in Abhydrolase Domain Containing 14A (ABHD14A) and the Suspicion of Aminoacylase 1 (ACY1) Deficiency

JIMD Reports, Volume 67, Issue 5, September 2026.
ABSTRACT Aminoacylase 1 (ACY1) deficiency is a rare autosomal recessive inborn error of metabolism, characterised by accumulation of N‐acetyl‐l‐amino acids in urine and highly variable clinical presentations. In contrast, the abhydrolase domain containing 14A (ABHD14A) has been suggested to play a role in various metabolic processes and may be linked ...
Lil Klaas, Estrella López‐Martín, Beatriz Martinez‐Delgado, Manuel Posada de la Paz, Antonia Ribes, Jörn Oliver Sass   +5 more
wiley   +1 more source

Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase

IUCrJ
Copper-containing nitrite reductases (CuNiRs) catalyse the reduction of nitrite to nitric oxide and are a key enzyme in the anaerobic ammonium oxidation and denitrification steps of the nitrogen cycle.
Nopphon Petchyam, Allegra Mbouku, Robert R. Eady, S. Samar Hasnain, Svetlana V. Antonyuk   +4 more
doaj   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Comprehensive Chemical and Biological Assessment of Orobanche racemosa Extracts Using Chromatographic, In Vitro, In Silico, and Cell‐Based Techniques

ChemistryOpen, Volume 15, Issue 9, September 2026.
Orobanche racemosa can be considered an effective source of natural bioactive agents in designing functional applications. The growing interest in natural product research as a safer and sustainable alternative to synthetic drugs has triggered this study, which evaluates the chemical profile and biological activity of Orobanche racemosa extracts.
Nilofar Nilofar, Enver Saka, Mehmet Veysi Cetiz, Maria J. Rodrigues, Eliana Fernandes, Luisa Custodio, Evren Yildiztugay, Ismail Yapıcı, Ilhami Gulcin, Esraa A. Elhawary, Omayma A. Eldahshan, Abdel Nasser B. Singab, Carlos L. Cespedes‐Acuna, Gokhan Zengin   +13 more
wiley   +1 more source

Differential Expression of Human and Bacterial Proteins Reveals Microbiome–Host Crosstalk in Metabolic Disorders

PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose The growing prevalence of obesity, MetS, and T2DM highlights the need to better understand host–microbiota interactions. While gut microbiota has been widely investigated, interactions between the oral microbiota and human salivary proteins remain largely unexplored.
Carlos Vinicius Ferreira da Silva, Carlos José Ferreira da Silva, Fernanda da Silva Marinho, Youssef Bacila Sade, Sandra Mara Naressi Scapin, Fabiano L. Thompson, Cristiane Thompson, Eidy de Oliveira Santos   +7 more
wiley   +1 more source

Outer‐Sphere Tuning of Synthetic Iron–Sulfur Clusters Within Nanoscale Cage Frameworks

Small, Volume 22, Issue 49, 1 September 2026.
Noncovalent encapsulation of a synthetic iron–sulfur cluster within hydrophobic, naphthalenediimide (NDI)‐paneled cages is shown to lead to dramatic changes in the electronic structure and covalency of the Fe─S core. ABSTRACT As atomic‐scale archetypes for multi‐electron transfer, iron–sulfur clusters are compelling candidates for the design of redox ...
Rupal Baliyan, Shelby T. Davis, Jan‐Niklas Boyn, Gwendolyn A. Bailey   +3 more
wiley   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science
Herpes simplex viruses (HSV‐1 and HSV‐2) are highly prevalent and contagious, causing lifelong infections that cannot be eradicated with current therapies.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
doaj   +1 more source

Metalloenzyme [PDF]

, 2017
D. Meißner, T. Arndt
openaire   +1 more source

Stable Copper‐Noble Metal Dual‐Atom Catalysts on 3D Graphene Microneedles for Enzyme‐Mimetic Biosensing of Phenolic Biomarkers

Small Structures, Volume 7, Issue 9, September 2026.
A sequential electrochemical deposition strategy anchors dual single‐atom catalysts on MoS2‐coated laser‐scribed graphene microneedles. Mimicking binuclear metalloenzyme active sites, the catalysts achieve enhanced stability and selective levodopa detection.
Saptami Suresh Shetty, Abdullah Bukhamsin, Shubham Singh, Yurii Tsyban, Mario Soto Martinez, Wildan Hanif, Messaoud Harfouche, Mohammed Ghadiyali, Khaled Mutabagani, Udo Schwingenschlögl, Dana Alsulaiman, Khaled Nabil Salama   +11 more
wiley   +1 more source