Optimizing Group Transfer Catalysis by Copper Complex with Redox-Active Ligand in an Entatic State
iScience, 2020 Summary: Metalloenzymes use earth-abundant non-noble metals to perform high-fidelity transformations in the biological world. To ensure chemical efficiency, metalloenzymes have acquired evolutionary reactivity-enhancing tools.
Yufeng Ren +8 more
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New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation
Doretta Cuffaro +6 more
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Iron conservation by reduction of metalloenzyme inventories in the marine diazotroph Crocosphaera watsonii [PDF]
, 2010 The marine nitrogen fixing microorganisms (diazotrophs) are a major source of nitrogen to open ocean ecosystems and are predicted to be limited by iron in most marine environments.
Bertrand, Erin M. +8 more
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Searching for novel carbonic anhydrase inhibitors: from virtual screening to the lab bench [PDF]
, 2013 Carbonic Anhydrases (CAs) are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate both in prokaryotes and eukaryotes.
Cadoni, Roberta +8 more
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Designed evolution of artificial metalloenzymes: protein catalysts made to order [PDF]
, 2007 Artificial metalloenzymes based on biotin–streptavidin technology, a fusion of chemistry and biology, illustrate how asymmetric catalysts can be improved and evolved using chemogenetic ...
Creus, Marc, Ward, Thomas R.
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Designing Hydrolytic Zinc Metalloenzymes
Biochemistry, 2014 Zinc is an essential element required for the function of more than 300 enzymes spanning all classes. Despite years of dedicated study, questions regarding the connections between primary and secondary metal ligands and protein structure and function remain unanswered, despite numerous mechanistic, structural, biochemical, and synthetic model studies ...
Zastrow, Melissa L. +1 more
openaire +2 more sources
Biochemical, kinetic, and spectroscopic characterization of Ruegeria pomeroyi DddW - A mononuclear iron-dependent DMSP lyase [PDF]
, 2015 The osmolyte dimethylsulfoniopropionate (DMSP) is a key nutrient in marine environments and its catabolism by bacteria through enzymes known as DMSP lyases generates dimethylsulfide (DMS), a gas of importance in climate regulation, the sulfur cycle, and ...
Brummett, Adam E +4 more
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Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors
Metabolites, 2018 Carbonic anhydrases (CAs) are a superfamily of metalloenzymes widespread in all life, classified into seven genetically different families (α–θ).
Niccolò Chiaramonte +3 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological processes and are expressed in both normal and cancerous cells.
Haytham O. Tawfik +7 more
doaj +1 more source
Artificial metalloenzymes : proteins as hosts for enantioselective catalysis [PDF]
, 2005 Enantioselective catalysis is one of the most efficient ways to synthesize high-added-value enantiomerically pure organic compounds. As the subtle details which govern enantioselection cannot be reliably predicted or computed, catalysis relies more and ...
Thomas, Christophe M., Ward, Thomas R.
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