Results 51 to 60 of about 10,865 (201)

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

The Role of Iron‐Hyponitrite Intermediates in Biology and Insights From Synthetic Model Complexes

Chemistry – A European Journal, EarlyView.
Despite the difference in active site architecture, NO reduction by different NOR enzymes is expected to be linked by a common intermediate: hyponitrite (N2O22−). However, experimentally, very little is known about the coordination chemistry of iron with hyponitrite and the expected Fe‐hyponitrite intermediates.
Michael O. Lengel, Nicolai Lehnert
wiley   +1 more source

Covalent Insertion of a Mn(Salen) Type Complex in Cross‐Linked Protein Crystals: Design of an Enantioselective Artificial Epoxidase

Chemistry – A European Journal, EarlyView.
An Artificial metalloenzyme was designed by a Michael addition between a MnSalen complex and a cysteine residue within NikA crystals. The heterogeneous catalyst was found capable of an enantioselective and stereospecific epoxidation of cis‐β‐methylstyrene in cristallo.
Manel Boukhallat, Ismail Benhamed, Jade Arnone, Stann Van Baaren, Clara Rinaldi, Patrice Catty, Caroline Marchi‐Delapierre, Christine Cavazza, Stéphane Ménage   +8 more
wiley   +1 more source

The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The activation of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacteria Brucella suis and Francisella tularensis with amine and amino acids was investigated. BsuCA 1 was sensitive to activation with amino acids and amines, whereas FtuCA was
Andrea Angeli, Sonia Del Prete, Mariana Pinteala, Stelian S. Maier, William A. Donald, Bogdan C. Simionescu, Clemente Capasso, Claudiu T. Supuran   +7 more
doaj   +1 more source

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

Frontiers in Pharmacology, 2020
Ectonucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of nucleoside tri- and di-phosphates to mono-phosphates. The products are subsequently hydrolyzed by ecto-5′-nucleotidase (ecto-5′-NT) to nucleosides.
Younis Baqi, Mahmoud Rashed, Laura Schäkel, Enas M. Malik, Julie Pelletier, Jean Sévigny, Jean Sévigny, Amelie Fiene, Christa E. Müller   +8 more
doaj   +1 more source

Ni2‐Imido Bispincer Platforms: Cooperative Reactivity Enabled Through Substrate Addition Across a Ni2N Unit

Chemistry – A European Journal, EarlyView.
Ni2 bispincer complexes with an embedded central imido anchor are presented. The bispincer complexes leverage the high basicity of imido ligands to facilitate 1,2 addition of weak B─H and Si─H bonds, resulting in hydrido–amido complexes and resultingly a contortion of a Ni─Ni sigma bond to form an S = 1 species. The 1,2 addition is proposed to serve as
David de los Santos, Kritika Gour, Manar M. Shoshani   +2 more
wiley   +1 more source

Insights to Industrial Electrocatalytic Sulfide Oxidation: Electrode Fabrication, System Engineering, and High‐Value Product Acquisition

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review summarizes recent advances in electrocatalytic sulfide oxidation (SOR), focusing on catalyst design strategies, reaction system engineering, and pathways for high‐value product generation. The roles of different reduced sulfur species (S2−, HS−, H2S) under various industrial conditions are highlighted, along with approaches to enhance ...
Zhongyuan Wang, Yinxi Han, Yufei Zhang, Jinghuan Chen, Jiade Wang   +4 more
wiley   +1 more source

Fluorinated and B‐Vinylated Tris(pyridyl)borate in Copper(I) Coordination Chemistry

European Journal of Inorganic Chemistry, EarlyView.
Coordinatively flexible tris(pyridyl)borate stabilizes copper coordination complexes, including those with ethylene and carbon monoxide. Fluorinated tris(pyridyl)borate with a vinyl substituent on boron was synthesized and comprehensively characterized, expanding the diversity and functional versatility of the poly(pyridyl)borate ligand family.
Deepika V. Karade, Mukundam Vanga, Xiuxiu Sun, H. V. Rasika Dias   +3 more
wiley   +1 more source

Nanomaterials Exhibiting Enzyme-Like Properties (Nanozymes): Current Advances and Future Perspectives

Frontiers in Chemistry, 2019
Biological enzymes are macromolecular catalysts that catalyze the biochemical reactions of the natural systems. Although each enzyme performs a particular function, however, holds several drawbacks, which limits its utilization in broad-spectrum ...
Sanjay Singh
doaj   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source