Results 221 to 230 of about 32,111 (260)

Metalloproteases Secreted by Actinobacillus suis

Current Microbiology, 2004
Actinobacillus suis secretes metalloproteases into its medium. These secreted proteins, when concentrated by precipitation with 70% (NH4)2SO4 or methanol, displayed proteolytic activity at >200 kDa molecular mass bands in 10% polyacrylamide gels copolymerized with bovine casein (1%).
Erasmo, Negrete-Abascal, Sergio Vaca, Pacheco, Gloria L, Paniagua, Alma Pérez, Méndez, Jorge Ibarra, Caballero, Víctor M Pérez, Márquez, Víctor R, Tenorio   +6 more
openaire   +2 more sources

The metalloprotease ADAM17 in inflammation and cancer

Pathology - Research and Practice, 2019
Proteolytic cleavage of transmembrane proteins is an important post-translational modification that regulates the biological function of numerous transmembrane proteins. Among the 560 proteases encoded in the human genome, the metalloprotease A Disintegrin and Metalloprotease 17 (ADAM17) has gained much attention in recent years and has emerged as a ...
Stefan, Düsterhöft, Juliane, Lokau, Christoph, Garbers   +2 more
openaire   +2 more sources

Roles of Metalloproteases in Metastatic Niche

Current Molecular Medicine, 2011
Metalloproteinases (MMPs) are a cluster of at least 23 enzymes belonging to the more wide family of endopeptidases called Metzincins, whose structure is characterized by the presence of a zinc ion at the catalytic site. Although the general view of MMPs as physiologic scissors involved in extracellular matrix (ECM) degradation and tissue remodeling is ...
RUCCI, Nadia, Sanita P, ANGELUCCI, ADRIANO   +2 more
openaire   +3 more sources

Matrix Metalloproteases as Biomarkers of Disease

2017
Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression ...
Fernando Luiz Affonso, Fonseca, Beatriz, da Costa Aguiar Alves, Ligia Ajaime, Azzalis, Thaís Moura Gáscon, Belardo   +3 more
openaire   +2 more sources

Matrix metalloproteases

Matrix metalloproteases (MMPs) are enzymes involved in the degradation of the extracellular matrix and display a critical role in a variety of physiological and pathological processes. They are of primary interest as therapeutic targets particularly for their role in carcinogenesis, but also in fibrosis, inflammation, abnormal angiogenesis, weakening ...
Trabocchi, Andrea, Lenci, Elena
openaire   +1 more source

Matrix Metalloproteases and Tumor Invasion

New England Journal of Medicine, 2005
A new study shows that a matrix metalloprotease cleaves the protease-activated receptor 1, thereby stimulating the migration and invasion of cancer cells.
openaire   +2 more sources

Two putative zinc metalloproteases contribute to the virulence of Clostridium perfringens strains that cause avian necrotic enteritis

Journal of Veterinary Diagnostic Investigation, 2020
Robert Moore, Julian Ian Rood, Anthony L Keyburn   +2 more
exaly  

Metalloproteases and Metalloprotease Inhibitors

2005
openaire   +1 more source

Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma

Digestive and Liver Disease, 2009
Manuel Rodríguez, Rodrigo L
exaly  

Molecular characterization and comparative study of 6 salivary gland metalloproteases from the hard tick, Haemaphysalis longicornis

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology, 2007
Yoshifumi Nishikawa, Benedicto Byamukama   +1 more
exaly