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Metalloproteases Secreted by Actinobacillus suis
Current Microbiology, 2004Actinobacillus suis secretes metalloproteases into its medium. These secreted proteins, when concentrated by precipitation with 70% (NH4)2SO4 or methanol, displayed proteolytic activity at >200 kDa molecular mass bands in 10% polyacrylamide gels copolymerized with bovine casein (1%).
Erasmo, Negrete-Abascal +6 more
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Metalloproteases of Leptospira
2021This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
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The metalloprotease ADAM17 in inflammation and cancer
Pathology - Research and Practice, 2019Proteolytic cleavage of transmembrane proteins is an important post-translational modification that regulates the biological function of numerous transmembrane proteins. Among the 560 proteases encoded in the human genome, the metalloprotease A Disintegrin and Metalloprotease 17 (ADAM17) has gained much attention in recent years and has emerged as a ...
Stefan, Düsterhöft +2 more
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Roles of Metalloproteases in Metastatic Niche
Current Molecular Medicine, 2011Metalloproteinases (MMPs) are a cluster of at least 23 enzymes belonging to the more wide family of endopeptidases called Metzincins, whose structure is characterized by the presence of a zinc ion at the catalytic site. Although the general view of MMPs as physiologic scissors involved in extracellular matrix (ECM) degradation and tissue remodeling is ...
RUCCI, Nadia +2 more
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Matrix Metalloproteases as Biomarkers of Disease
2017Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression ...
Fernando Luiz Affonso, Fonseca +3 more
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Matrix metalloproteases (MMPs) are enzymes involved in the degradation of the extracellular matrix and display a critical role in a variety of physiological and pathological processes. They are of primary interest as therapeutic targets particularly for their role in carcinogenesis, but also in fibrosis, inflammation, abnormal angiogenesis, weakening ...
Trabocchi, Andrea, Lenci, Elena
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Trabocchi, Andrea, Lenci, Elena
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Matrix Metalloproteases and Tumor Invasion
New England Journal of Medicine, 2005A new study shows that a matrix metalloprotease cleaves the protease-activated receptor 1, thereby stimulating the migration and invasion of cancer cells.
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