Results 181 to 190 of about 24,294 (246)
Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness
Genes to Cells, Volume 31, Issue 3, May 2026.COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon +8 more
wiley +1 more source
Genes to Cells, Volume 31, Issue 3, May 2026.Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino +2 more
wiley +1 more source
The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey [PDF]
, 2017 Bateman, Randy J, et al,
core +2 more sources
Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak +6 more
wiley +1 more source
Genetic Variation in Chemical Defence Affects Protection of an Herbivorous Insect Against Predation
Molecular Ecology, Volume 35, Issue 9, May 2026.ABSTRACT Genetic variation contributes to intraspecific differences in the chemical defence in many insect species, yet the underlying genetic mechanisms remain poorly understood. The horseradish flea beetle, Phyllotreta armoraciae, sequesters glucosinolates from its horseradish host plant and activates them using endogenous myrosinase enzymes.
Johannes Körnig +9 more
wiley +1 more source
EFSA Journal, Volume 24, Issue 5, May 2026.Abstract The food enzyme containing metalloendopeptidase (EC 3.4.24) and leucyl aminopeptidase (EC 3.4.11.1) activities is produced with the non‐genetically modified Aspergillus oryzae strain HBI‐POP01 by HBI Enzymes Inc. The food enzyme was considered free from viable cells of the production organism.
EFSA Panel on Food Enzymes (FEZ) +19 more
wiley +1 more source
Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade +2 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Serum SERPINA3 levels were higher in BOS compared to non‐BOS patients. OPG and SERPINA3 positive cells colocalized with tryptase positive mast cells in airways from BOS lung tissue. OPG and SERPINA3 staining positively correlated in partially and completely obstructed airways.
Yanzhe Liu +8 more
wiley +1 more source
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells [PDF]
, 2008 Delputte, Peter +2 more
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