Results 191 to 200 of about 24,294 (246)
Snakebite on the hand: Lessons from two clinical cases illustrating difficulties of Surgical Indication [PDF]
, 2012 Gras, S
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Metalloproteases and inhibitors in arthritic diseases
Best Practice and Research in Clinical Rheumatology, 2001Controlling degradation of the extracellular matrix is crucial in arthritic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA), as conventional treatments do not positively affect the structural properties of the articular tissues. Metalloproteases, a family of zinc-dependent enzymes, and more specifically the matrix metalloproteases ...
Johanne Martel-Pelletier +1 more
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Metalloproteases and intracranial vascular lesions
Neurological Research, 1999Recent studies have suggested that metalloproteinases (MMP) might be involved in the pathogenesis of cerebral aneurysm formation and rupture and that elevated serum levels of MMP may effectively be considered as possible markers of cerebrovascular malformations.
Riccardo Rodriguez Y Baena +2 more
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Membranes, 2022 The proteolytical cleavage of transmembrane proteins with subsequent release of their extracellular domain, so-called ectodomain shedding, is a post-translational modification that plays an essential role in several biological processes, such as cell ...
Donatella Pia Spanò
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Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?
Biology, 2020 Pancreatic cancer is a dismal disorder that is histologically characterized by a dense fibrotic stroma around the tumor cells. As the extracellular matrix comprises the bulk of the stroma, matrix degrading proteases may play an important role in ...
Etienne J Slapak +2 more
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Metalloproteases and the Degradome
2010Metalloproteases comprise a heterogeneous group of proteolytic enzymes whose main characteristic is the utilization of a metal ion to polarize a water molecule and perform hydrolytic reactions. These enzymes represent the most densely populated catalytic class of proteases in many organisms and play essential roles in multiple biological processes.
Alejandro P, Ugalde +4 more
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Microbial metalloproteases and pathogenesis
Microbes and Infection, 2000Zinc metalloproteases produced by human pathogenic microorganisms show a wide variety of pathological actions. In local infections, the proteases cause necrotic or hemorrhagic tissue damage through digestion of structural components of the ground substance, and also form edematous lesions through generation of inflammatory mediators, while in systemic ...
S, Miyoshi, S, Shinoda
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Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family
Journal of Proteome Research, 2011The "a disintegrin and metalloproteases" (ADAMs) are membrane-anchored metzincins of the adamalysin subfamily. This review gives an overview over the biological function and structure of ADAMs focusing on members of the family that display proteolytic activity.
Klein, Theo, Bischoff, Rainer
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Moschcowitz, Multimers, and Metalloprotease
New England Journal of Medicine, 1998In 1924, Dr. Eli Moschcowitz described the abrupt onset of petechiae and pallor, followed rapidly by paralysis, coma, and death, in a 16-year-old girl.1 Terminal arterioles and capillaries in the d...
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Metalloproteases in gonad formation and ovulation
General and Comparative Endocrinology, 2021Changes in expression or activation of various metalloproteases including matrix metalloproteases (Mmp), a disintegrin and metalloprotease (Adam) and a disintegrin and metalloprotease with thrombospondin motif (Adamts), and their endogenous inhibitors (tissue inhibitors of metalloproteases, Timp), have been shown to be critical for ovulation in various
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