Results 101 to 110 of about 22,661 (298)
Design of functional metalloproteins [PDF]
Nature, 2009 Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their ...
Yi, Lu +3 more
openaire +2 more sources
ChemMedChem, Volume 21, Issue 1, January 2026.A set of three cysteine‐derived hydroxamic acids were synthesized and evaluated for human gloxalase‐1 inhibition and ferroptosis induction activities. Among them, compound 2 exhibited a potent inhibitory effect against human glyoxalase‐1 and induced ferroptosis in non‐small cell lung cancer cell lines, increasing reactive oxygen species production and ...
Josué Martínez‐Miranda +7 more
wiley +1 more source
ChemPhysChem, Volume 27, Issue 2, January 2026.We performed electron paramagnetic resonance (EPR) experiments to reveal that P. aerguinosa CueR copper transcription factor enhances expression of copZ2 more strongly than mexPQ‐opmE under copper stress, consistent with their detoxification roles. Findings highlight EPR as a key tool for probing metal‐regulated transcription.
Ameer Yasin +5 more
wiley +1 more source
Uji Efektivitas Beberapa Jenis Arang Aktif dan Tanaman Akumulator Logam pada Lahan Bekas Penambangan Emas [PDF]
, 2012 Tujuan penelitian ini adalah untuk mengetahui efektivitas jenis arang aktif yang berasal dari bahan baku tempurung kelapa, tempurung kelapa sawit dan sekam padi serta tanaman akumulator sawi hijau, sawi huma dan sawi pahit dalam menyerap logam berat Cu ...
Mustamir, E. (Elly) +2 more
core
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity [PDF]
, 2010 Engineered metalloproteins constitute a flexible new class of analyte-sensitive molecular imaging agents detectable by magnetic resonance imaging (MRI), but their contrast effects are generally weaker than synthetic agents.
Alan Jasanoff +21 more
core +2 more sources
Quantum medicine: A quantum–mechanical framework for redox biology, disease and precision medicine
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Quantum medicine integrates quantum simulation, experimental validation and clinical data into a unified QEC pipeline. Quantum algorithms compute electronic and spin‐level properties of redox biology, which are validated by quantum sensing and structural biology and translated into precision diagnostics and therapy through multi‐omics and quantum ...
Ji‐Yong Sung, Jae‐Ho Cheong
wiley +1 more source
Frontiers in Pharmacology, 2019 Background: Fibroblast growth factor 21 (FGF21), a member of a family of atypical FGFs, functions as cytokine to control endocrinology and metabolism. Recently, the roles of FGF21 in cardio-cerebral-vascular diseases have been gradually uncovered. In the
Hao-Wei Wang +6 more
doaj +1 more source
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria [PDF]
, 2018 Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear.
Díaz Moreno, Irene +7 more
core +1 more source
Journal of Nanobiotechnology, 2016 BackgroundIn a biological system, an engineered nanomaterial (ENM) surface is altered by adsorbed proteins that modify ENM fate and toxicity. Thus far, protein corona characterizations have focused on protein adsorption, interaction strength, and ...
D. Freitas +3 more
semanticscholar +1 more source