Results 1 to 10 of about 46,373 (100)

5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone up-regulates miR-145 expression and inhibits proliferation of gastric cancer cells

Archives of Medical Science, 2021
Introduction Gastric cancer is a frequently detected malignancy, and its incidence has increased over the past decades in East Asia. The present study investigated the effect of 5,7,2, 5-tetrahydroxy-8,6-dimethoxyflavone (THDMF) on gastric cancer cells ...
Chunhong Wei, Peng Jiang, Guangxu Li, Meng Li, Li Wang   +4 more
doaj   +1 more source

Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor

Frontiers in Cardiovascular Medicine, 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the ...
Maggie Wang, Adekunle Alabi, Hong-mei Gu, Govind Gill, Ziyang Zhang, Suha Jarad, Xiao-dan Xia, Xiao-dan Xia, Yishi Shen, Gui-qing Wang, Da-wei Zhang   +10 more
doaj   +1 more source

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation

Frontiers in Immunology, 2022
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to ...
Lichchavi D. Rajasinghe, Lichchavi D. Rajasinghe, Melissa A. Bates, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka, James J. Pestka, James J. Pestka   +9 more
doaj   +1 more source

Vaginal Microbiota, Genital Inflammation and Extracellular Matrix Remodelling Collagenase: MMP-9 in Pregnant Women With HIV, a Potential Preterm Birth Mechanism Warranting Further Exploration

Frontiers in Cellular and Infection Microbiology, 2021
BackgroundPregnant women living with HIV infection (PWLWH) have elevated rates of preterm birth (PTB) in which HIV and cART are implicated. PWLWH also have a high prevalence of adverse vaginal microbiota, which associate with genital tract inflammation ...
Charlotte-Eve S. Short, Charlotte-Eve S. Short, Rachael A. Quinlan, Rachael A. Quinlan, Xuan Wang, Veronica Georgiana Preda, Veronica Georgiana Preda, Ann Smith, Ann Smith, Julian R. Marchesi, Julian R. Marchesi, Yooni S. Lee, Yooni S. Lee, David A. MacIntyre, David A. MacIntyre, Phillip R. Bennett, Phillip R. Bennett, Graham P. Taylor, Graham P. Taylor   +18 more
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Pseudomonas aeruginosa Alters Critical Lung Epithelial Cell Functions through Activation of ADAM17

Cells, 2022
Severe epithelial dysfunction is one major hallmark throughout the pathophysiological progress of bacterial pneumonia. Junctional and cellular adhesion molecules (e.g., JAMA-A, ICAM-1), cytokines (e.g., TNFα), and growth factors (e.g., TGFα), controlling
Ahmad Aljohmani, Noah Niklas Andres, Daniela Yildiz   +2 more
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Coumarin Derivatives Act as Novel Inhibitors of Human Dipeptidyl Peptidase III: Combined In Vitro and In Silico Study

Pharmaceuticals, 2021
Dipeptidyl peptidase III (DPP III), a zinc-dependent exopeptidase, is a member of the metalloproteinase family M49 with distribution detected in almost all forms of life.
Dejan Agić, Maja Karnaš, Domagoj Šubarić, Melita Lončarić, Sanja Tomić, Zrinka Karačić, Drago Bešlo, Vesna Rastija, Maja Molnar, Boris M. Popović, Miroslav Lisjak   +10 more
doaj   +1 more source

A Marine λ-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis

Marine Drugs, 2021
Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis ...
Rémi Cousin, Hugo Groult, Chanez Manseur, Romain Ferru-Clément, Mario Gani, Rachel Havret, Claire Toucheteau, Grégoire Prunier, Béatrice Colin, Franck Morel, Jean-Marie Piot, Isabelle Lanneluc, Kévin Baranger, Thierry Maugard, Ingrid Fruitier-Arnaudin   +14 more
doaj   +1 more source

Aortopathy pathophysiology features in patients with bicuspid aortic valve. [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2016
This review is devoted to one of the vital topics in cardiovascular surgery – pathophysiologyof an aortopathy in case of bicuspid aortic valve. In the article reviewed the modern point of view on a problem considering new achievements in genetics ...
Arystan Seidalin, Turlybek Tuganbekov, Vladimir Dikolayev, Serik Aitaliyev   +3 more
doaj   +1 more source

Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation

Toxins, 2016
Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims.
Ana M. Moura-da-Silva, Michelle T. Almeida, José A. Portes-Junior, Carolina A. Nicolau, Francisco Gomes-Neto, Richard H. Valente   +5 more
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Vibrio vulnificus MO6-24/O Lipopolysaccharide Stimulates Superoxide Anion, Thromboxane B2, Matrix Metalloproteinase-9, Cytokine and Chemokine Release by Rat Brain Microglia in Vitro

Marine Drugs, 2014
Although human exposure to Gram-negative Vibrio vulnificus (V. vulnificus) lipopolysaccharide (LPS) has been reported to result in septic shock, its impact on the central nervous system’s innate immunity remains undetermined.
Alejandro M. S. Mayer, Mary L. Hall, Michael Holland, Cristina De Castro, Antonio Molinaro, Monica Aldulescu, Jeffrey Frenkel, Lauren Ottenhoff, David Rowley, Jan Powell   +9 more
doaj   +1 more source