Results 11 to 20 of about 181,236 (248)

Isolation, characterization, and expression of the Montivipera raddei (Caucasus viper) venom metalloprotease-like protein [PDF]

Research in Pharmaceutical Sciences
Background and purpose: Snake venom contains numerous proteolytic enzymes, including metalloproteases. This study aimed to isolate, characterize the metalloproteinase from Montivipera raddei venom and insert its cDNA into a host cell genome for ...
Zohreh Jafari, Behnam Sedaghati, Mohammad Kaboli, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +2 more sources

Biological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom

Toxins, 2010
In our previous report, rosmarinic acid (RA) was revealed to be an antidote active compound in Argusia argentea (family: Boraginaceae). The plant is locally used in Okinawa in Japan as an antidote for poisoning from snake venom, Trimeresurus flavoviridis
Masatake Niwa, Yoshiaki Takaya, Tsunemasa Nonogaki, Toshiaki Nikai, Yumiko Komori, Hnin Thanda Aung   +5 more
doaj   +1 more source

Matrix Proteins and Proteinases Network in Human Cardiovascular Diseases Explored By Cytoscape [PDF]

Research Ideas and Outcomes, 2016
Matrix proteins and proteinases altered extracellular matrix that involves in various pathogenesis of cardiovascular diseases. Systematic review selected matrix metalloproteinase-7 (MMP7), a disintegrin and metalloproteinase-17 (ADAM17), type I collagen (
Robert Chen, Wei-hsuan Yu
doaj   +2 more sources

Peptide-Based Inhibitors of ADAM and ADAMTS Metalloproteinases

Frontiers in Molecular Biosciences, 2021
ADAM and ADAMTS are two large metalloproteinase families involved in numerous physiological processes, such as shedding of cell-surface protein ectodomains and extra-cellular matrix remodelling.
Stefano Pluda, Stefano Pluda, Ylenia Mazzocato, Alessandro Angelini, Alessandro Angelini   +4 more
doaj   +1 more source

In Vitro Preventive Effect and Mechanism of Action of Weissella cibaria CMU against Streptococcus mutans Biofilm Formation and Periodontal Pathogens

Microorganisms, 2023
In this study, we evaluated the in vitro anti-biofilm, antibacterial, and anti-inflammatory activity of Weissella cibaria CMU (CMU), an oral probiotic, against periodontopathogens.
Mi-Sun Kang, Geun-Yeong Park, A-Reum Lee
doaj   +1 more source

Elimination of macrophages reduces glutaraldehyde‐fixed porcine heart valve degeneration in mice subdermal model

Pharmacology Research & Perspectives, 2021
Glutaraldehyde‐fixed porcine heart valve (GPHV) calcify and deteriorate over time. The aim of this study was to explore the roles macrophages play in mediating calcification and degeneration of the valve's connective tissue matrix.
Zongtao Liu, Yixuan Wang, Fei Xie, Xing Liu, Fei Li, Nianguo Dong   +5 more
doaj   +1 more source

Sub-Cellular Localization of Metalloproteinases in Megakaryocytes

Cells, 2018
Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis.
Alessandro Malara, Daniela Ligi, Christian A. Di Buduo, Ferdinando Mannello, Alessandra Balduini   +4 more
doaj   +1 more source

A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A₂

Biomolecules, 2021
Matrix metalloproteinases (MMPs) are proteolytic enzymes that have been associated with the pathogenesis of inflammatory diseases and obesity. Adipose tissue in turn is an active endocrine organ capable of secreting a range of proinflammatory mediators ...
Priscila Motta Janovits, Elbio Leiguez, Viviane Portas, Catarina Teixeira   +3 more
doaj   +1 more source

Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy

Clinical and Translational Medicine, 2021
Background Diabetic nephropathy (DN), one of the major complications of diabetes, is characterized by albuminuria, glomerulosclerosis, and progressive loss of renal function.
Viviana Casagrande, Giulia Iuliani, Stefano Menini, Giuseppe Pugliese, Massimo Federici, Rossella Menghini   +5 more
doaj   +1 more source

Divergent Specialization of Simple Venom Gene Profiles among Rear-Fanged Snake Genera (Helicops and Leptodeira, Dipsadinae, Colubridae)

Toxins, 2022
Many venomous animals express toxins that show extraordinary levels of variation both within and among species. In snakes, most studies of venom variation focus on front-fanged species in the families Viperidae and Elapidae, even though rear-fanged ...
Peter A. Cerda, Jenna M. Crowe-Riddell, Deise J. P. Gonçalves, Drew A. Larson, Thomas F. Duda, Alison R. Davis Rabosky   +5 more
doaj   +1 more source