Results 271 to 280 of about 231,111 (308)

Matrix metalloproteinases

Current Opinion in Chemical Biology, 1998
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis

Current Opinion in Lipidology, 1998
The ability of the metalloproteinases to degrade extracellular matrix proteins is essential for the matrix remodelling that occurs during infiltration of inflammatory cells, intimal thickening, angiogenesis and plaque rupture which are a result of atherosclerosis.
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Agavain: A metalloproteinase

Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
Summary 1. Crystalline agavain has been shown to be inhibited by metal binding agents and DFP, but not by sulfhydryl reagents. 2. The activity of agavain is sensitive to the nature of the buffer solution used in the assay medium, this inhibitory effect being a function of the buffer anions. 3.
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Measurement of Metalloproteinases

2003
Matrix metalloproteinases (MMPs) (1,2) comprise a family of over 20 matrix degrading enzymes believed to be essential for normal development and physiologic tissue remodeling and repair. Abnormal expression of metalloproteinases has been implicated in many destructive processes, including tumor cell invasion and angiogenesis, arthritis, atherosclerosis,
S D, Shapiro, D, Kelley, D, Kobayashi
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Structural Basis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Molecular Biotechnology, 2003
The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all of which exhibit a catalytic domain of a common metzincin-like topology, and which are involved in degradation of the extracellular matrix but also in a number of other biologic processes. Normally, the proteolytic activity of
Maskos, K., Bode, W.
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Matrix Metalloproteinases

2012
Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many ...
Viola, Vargová, Marek, Pytliak, Viola, Mechírová   +2 more
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Characterization of Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Plasma

Connective Tissue Research, 1992
In this study, we have identified and characterized metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) in human plasma. Treatment of plasma with trypsin or aminophenylmercuric acetate resulted in activation of latent gelatinolytic activity.
D, Moutsiakis, P, Mancuso, H, Krutzsch, W, Stetler-Stevenson, S, Zucker   +4 more
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function

Reviews of Reproduction, 1998
Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the ...
E W, McIntush, M F, Smith
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas

Journal of Neurosurgery, 1995
✓ The gene expression of five matrix metalloproteinases (MMPs) and two tissue inhibitors of metalloproteinases (TIMPs) was studied in human gliomasin vivoandin vitroto evaluate their roles in glioma invasion. Simultaneous expression of one to four MMP genes and two TIMP genes was found in 17 surgical glioma specimens, and one MMP (gelatinase A) gene ...
A, Nakano, E, Tani, K, Miyazaki, Y, Yamamoto, J, Furuyama   +4 more
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Metalloproteinases and their inhibitors in angiogenesis

Expert Reviews in Molecular Medicine, 2003
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being crucial for the growth of solid ...
Lafleur, M.A., Handsley, M.M., Edwards, D.R.   +2 more
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