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Recent advances and future challenges in predictive modeling of metalloproteins by artificial intelligence [PDF]
Molecules and Cells: Metal coordination is essential for structural/catalytic functions of metalloproteins that mediate a wide range of biological processes in living organisms. Advances in bioinformatics have significantly enhanced our understanding of metal-binding sites
Soohyeong Kim +4 more
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Changing paradigms for the micronutrient zinc, a known protein cofactor, as a signal relaying also cellular redox state [PDF]
Quantitative Plant BiologyThe micronutrient zinc (Zn) is often poorly available but toxic when present in excess, so a tightly controlled Zn homoeostasis network operates in all organisms. This review summarizes our present understanding of plant Zn homoeostasis.
Ute Krämer
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Structure and Catalytic Mechanism of Radical SAM Methylases
Life, 2022 Methyl transfer is essential in myriad biological pathways found across all domains of life. Unlike conventional methyltransferases that catalyze this reaction through nucleophilic substitution, many members of the radical S-adenosyl-L-methionine (SAM ...
Tu-Quynh Nguyen, Yvain Nicolet
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Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy
Biomolecules, 2022 Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen ...
Mickaël V. Cherrier +8 more
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Nature Communications, 2022 ThiH is a radical SAM L-tyrosine lyase involved in the biosynthesis of the thiazole ring of vitamin B1. Here, the authors report the crystal structure of ThiH in complex with its L-tyrosine substrate, revealing an unexpected protonation state and ...
Patricia Amara +4 more
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Inorganics, 2023 The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability.
Jason C. Crack +8 more
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Communications Biology, 2022 The crystal structure of the iron-sulfur protein NsrR from Streptomyces coelicolor bound to a gene operator fragment is reported and compared with other structures, giving insight into the structural determinants of DNA recognition by the NO sensor.
Roman Rohac +6 more
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Machine Learning Approaches for Metalloproteins
Molecules, 2022 Metalloproteins are a family of proteins characterized by metal ion binding, whereby the presence of these ions confers key catalytic and ligand-binding properties.
Yue Yu, Ruobing Wang, Ruijie D. Teo
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Effects of Ionic Liquids on Metalloproteins
Molecules, 2021 In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline.
Aashka Y. Patel +5 more
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Bioinformatics of Metalloproteins and Metalloproteomes
Molecules, 2020 Trace metals are inorganic elements that are required for all organisms in very low quantities. They serve as cofactors and activators of metalloproteins involved in a variety of key cellular processes.
Yan Zhang, Junge Zheng
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