Results 31 to 40 of about 75,382 (270)

Tissue-specific expression from a compound TATA-dependent and TATA-independent promoter [PDF]

, 1990
We have found that the mouse metallothionein-I (MT-I) gene promoter functions in an unusual, compound manner. It directs both TATA-dependent and TATA-independent modes of transcription in vivo.
Garrity, Paul A., Wold, Barbara J.
core   +2 more sources

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

Diagnostic Pathology, 2012
Background In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle.
Ozer Hatice, Yenicesu GoncaImir, Arici Sema, Cetin Meral, Tuncer Ersin, Cetin Ali   +5 more
doaj   +1 more source

Metallothionein–Kidney Bean Polyphenol Complexes Showed Antidiabetic Activity in Type 2 Diabetic Rats by Improving Insulin Resistance and Regulating Gut Microbiota

Foods, 2023
Previous studies have shown that interaction between polyphenols and proteins can benefit health, but the mechanism of its antidiabetic effect has not been thoroughly elucidated.
Zhaohang Zuo, Weiqiao Pang, Wei Sun, Baoxin Lu, Liang Zou, Dongjie Zhang, Ying Wang   +6 more
doaj   +1 more source

Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters

Metabolites, 2023
The inflammatory reaction and pathogenesis of COVID-19 may be modulated by circulating trace elements (Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn)) and Metallothioneins (MTs).
Lourdes Herrera-Quintana, Héctor Vázquez-Lorente, Yenifer Gamarra-Morales, Jorge Molina-López, Elena Planells   +4 more
doaj   +1 more source

The toxicity of cadmium and resulting hazards for human health [PDF]

, 2006
Cadmium (Cd) has been in industrial use for a long period of time. Its serious toxicity moved into scientific focus during the middle of the last century.
Brandenburg, Paul, Esche, Vera, Godt, Johannes, Groneberg, Jan David Alexander, Grosse-Siestrup, Christian, Reich, Andrea, Scheidig, Franziska   +6 more
core   +2 more sources

Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis

Frontiers in Endocrinology, 2022
BackgroundNon-alcoholic fatty liver disease (NAFLD), a metabolic disorder that develops from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), has become an epidemic of chronic liver dysfunction worldwide. However, mechanisms that
Xiaoya Li, Shaoping Zhong, Yifan Sun, Xinmei Huang, Yue Li, Lihong Wang, Yueyue Wu, Min Yang, Hai-Xin Yuan, Jun Liu, Shufei Zang   +10 more
doaj   +1 more source

Mice in ecstasy : advanced animal models in the study of MDMA [PDF]

, 2010
The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy- has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy.
Stove, Christophe, De Letter, Els, Piette, Michel, Lambert, Willy   +3 more
core   +2 more sources

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength [PDF]

, 2015
Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice
Chavassieux, P, Chenu, C, Hopkinson, M, Javaheri, B, Kopchick, J, Korbonits, M, Lim, SV, List, E, Marenzana, M, Pereira, M, Roux, J   +10 more
core   +4 more sources

Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications

Antioxidants
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
Ruoqiu Yang, Dumila Roshani, Boya Gao, Pinglan Li, Nan Shang   +4 more
doaj   +1 more source

Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes

Molecular Brain, 2010
Zinc dyshomeostasis has been recognized as an important mechanism for cell death in acute brain injury. An increase in the level of free or histochemically reactive zinc in astrocytes and neurons is considered one of the major causes of death of these ...
Lee Sook-Jeong, Koh Jae-Young
doaj   +1 more source