Results 251 to 260 of about 1,037,437 (317)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Risk stratification in colorectal cancer: A retrospective cohort study of nomograms based on inflammatory and immunohematological biomarkers. [PDF]

J Int Med Res
Tang J, Xiang M, Xiong G, Chen L, Liao Y, Shen X, Li R, Lin Y, Zhang K, Xie L.   +9 more
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Bone remodeling: a central mechanism in prostate cancer bone metastasis. [PDF]

PeerJ
Tang H, Chen J, Wu H, Lv Y, Wa Q, He S.
europepmc   +1 more source

Machine Learning Models for Predicting Liver Metastasis at Diagnosis and Overall Survival in Ovarian Cancer: A SEER-Based Study. [PDF]

Int J Womens Health
Li C, Huang L, Jiang R.
europepmc   +1 more source

RETRACTION: miR-127-5p Targets JAM3 to Regulate Ferroptosis, Proliferation, and Metastasis in Malignant Meningioma Cells. [PDF]

Dis Markers
Markers D.
europepmc   +1 more source

Inhibition of SRC prevents bone metastasis of breast cancer by blocking metastatic cell motility and bone directionality. [PDF]

Theranostics
Choi YJ, Kwon M, Kim MJ, Choi M, Tran PT, Lee Y, Shim WS, Kang M, Oh S, Lim SC, Kim YC, Kang KW.   +11 more
europepmc   +1 more source

A multimodal ultrasound-based model combining tumor radiomics and axillary lymph node morphologic classification for predicting axillary nodal burden in breast cancer. [PDF]

Front Endocrinol (Lausanne)
Lu R, Yang T, Pan L, Shao L, Zhang L, Sun F, Du J, Zhao L.   +7 more
europepmc   +1 more source