Results 51 to 60 of about 1,204,560 (279)

Narciclasine enhances cisplatin-induced apoptotic cell death by inducing unfolded protein response-mediated regulation of NOXA and MCL1

Cellular & Molecular Biology Letters
Background Platinum-based chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC); however, innate and acquired resistance is clinically seen in many patients.
Ji Hae Lee, Seung Hee Seo, Jaegal Shim, Yong-Nyun Kim, Kyungsil Yoon   +4 more
doaj   +1 more source

Mathematical Reconstruction of Patient-Specific Vascular Networks Based on Clinical Images and Global Optimization

IEEE Access, 2021
Cancer is a major cause of death worldwide and becomes particularly threatening once it begins to metastasize. During metastasis, the blood vessels serve as pathways for cancerous cell transportation and hence are crucial for understanding cancer growth.
Junhong Shen, Abdul Hannan Faruqi, Yifan Jiang, Nima Maftoon   +3 more
doaj   +1 more source

Renal Cell Carcinoma Presenting as Metastasis to Scrotum and Spermatic Cord [PDF]

, 2012
Unusual site metastasis as presenting complaint of renal cell carcinoma (RCC) has been reported previously in literature. RCC is a notorious tumor with unpredictable behavior.
Bhatia, V, Chandel, UK, Jaswal, KS, Jhobta, A, Panda, P, Sharma, S   +5 more
core  

Endotracheal Metastasis Causing Airway Obstruction [PDF]

, 2020
Endotracheal metastasis, a critical complication of primary lung cancer, is an extremely rare lesion. A 73-year-old woman who had previously received treatment for lung cancer presented to our emergency department with dyspnea.
Fujiwara, Takashi, Mizuta, Masanobu, Yano, Yudai   +2 more
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Tmem119 expression is downregulated in a subset of brain metastasis-associated microglia

BMC Neuroscience
Under pathological conditions, the immune-specialized brain microenvironment contains both resident microglia and bone marrow-derived myeloid cells recruited from peripheral circulation.
Weili Ma, Jack Oswald, Angela Rios Angulo, Qing Chen   +3 more
doaj   +1 more source

Tumor-targeting adenovirus OBP-401 inhibits primary and metastatic tumor growth of triple-negative breast cancer in orthotopic nude-mouse models. [PDF]

, 2016
Our laboratory previously developed a highly-invasive, triple-negative breast cancer (TNBC) variant using serial orthotopic implantation of the human MDA-MB-231 cell line in nude mice.
Bouvet, Michael, Fujiwara, Toshiyoshi, Hoffman, Robert M, Kagawa, Shunsuke, Kishimoto, Hiroyuki, Takehara, Kiyoto, Tazawa, Hiroshi, Urata, Yasuo, Yano, Shuya   +8 more
core   +2 more sources

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype

iScience, 2021
Summary: Therapy-induced senescence-associated secretory phenotype (SASP) correlates with overcoming resistance to immune checkpoint blockade (ICB). Intrinsic resistance to ICB is a major clinical challenge.
Xue Hao, Bo Zhao, Wei Zhou, Heng Liu, Takeshi Fukumoto, Dmitry Gabrilovich, Rugang Zhang   +6 more
doaj  

Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271

Cancer Biology & Medicine, 2019
Objective Cancer metastasis remains the primary cause of cancer-related death worldwide. In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.
Weiyu Shen, Yumei Li, Bifei Li, Liping Zheng, Xiaodong Xie, Jingqing Le, Yusheng Lu, Tao Li, Fan Chen, Lee Jia   +9 more
doaj   +1 more source