Results 1 to 10 of about 1,650,595 (291)

Metastatic breast cancer [PDF]

, 2021
Although the prognosis of patients with disseminated breast cancer has improved in recent years, it remains the leading cause of death in women aged 40 to 60. This thesis shows that in daily practice, the prognosis of patients with disseminated breast cancer is influenced by various factors, such as hormone receptor and HER2 receptor status and time ...
Giuseppe Buono, Francesco Schettini, Grazia Arpino, Mario Giuliano, Sabino De Placido   +4 more
  +6 more sources

Trastuzumab deruxtecan in metastatic breast cancer with variable HER2 expression: the phase 2 DAISY trial

Nature Medicine, 2023
The mechanisms of action of and resistance to trastuzumab deruxtecan (T-DXd), an anti-HER2–drug conjugate for breast cancer treatment, remain unclear. The phase 2 DAISY trial evaluated the efficacy of T-DXd in patients with HER2-overexpressing ( n  = 72,
F. Mosele, É. Deluche, A. Lusque, Loïc Le Bescond, T. Filleron, Yoann Pradat, A. Ducoulombier, B. Pistilli, T. Bachelot, F. Viret, C. Lévy, N. Signolle, Alexia Alfaro, D. Tran, I. Garberis, H. Talbot, S. Christodoulidis, M. Vakalopoulou, N. Droin, A. Stourm, Maki Kobayashi, T. Kakegawa, L. Lacroix, P. Saulnier, B. Job, Marc Deloger, M. Jimenez, C. Mahier, Vianney Baris, Pierre Laplante, P. Kannouche, V. Marty, M. Lacroix-Triki, V. Diéras, F. André   +34 more
semanticscholar   +1 more source

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

New England Journal of Medicine, 2021
Copyright © 2021 Massachusetts Medical Society. BACKGROUND Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody–drug conjugate composed of an antibody targeting the human trophoblast cell ...
A. Bardia, S. Hurvitz, S. Tolaney, D. Loirat, K. Punie, Mafalda Oliveira, A. Brufsky, S. Sardesai, K. Kalinsky, A. Zelnak, R. Weaver, T. Traina, F. Dalenc, P. Aftimos, F. Lynce, S. Diab, J. Cortés, J. O’Shaughnessy, V. Diéras, C. Ferrario, P. Schmid, L. Carey, L. Gianni, M. Piccart, S. Loibl, D. Goldenberg, Q. Hong, M. Olivo, L. Itri, H. Rugo   +29 more
semanticscholar   +1 more source

Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. [PDF]

, 2014
Bone metastasis is a lethal and morbid late stage of breast cancer that is currently treatment resistant. More effective mouse models and treatment are necessary.
Bouvet, Michael, Hayashi, Katsuhiro, Hiroshima, Yukihiko, Hoffman, Robert M, Kimura, Hiroaki, Matsumoto, Yasunori, Miwa, Shinji, Tsuchiya, Hiroyuki, Uehara, Fuminari, Yamamoto, Mako, Yamamoto, Norio, Yano, Shuya, Zhang, Yong, Zhao, Ming   +13 more
core   +5 more sources

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa, Compte, Marta, Cuesta, Ángel M., Fernández-Periáñez, Rodrigo, Guijarro-Muñoz, Irene, Molina-Privado, Irene, Rojo, Federico, Sanz, Laura, Sánchez-Martín, David, Zazo, Sandra, Álvarez-Cienfuegos, Ana, Álvarez-Méndez, Ana M., Álvarez-Vallina, Luis   +12 more
core   +8 more sources

Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]

, 2014
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome,and the choice of therapy ...
A Santinelli, AJ Montero, Alastair M Thompson, AM Thompson, Angela Esposito, Aron Goldhirsch, B Weigelt, BG Mobbs, C Liedtke, C Simmons, C Tapia, CA Gomez-Roca, Carmen Criscitiello, CH Lu, D Gancberg, DS Seah, E Amir, E Amir, E Brogi, EA Mittendorf, EA Perez, EA Perez, EE Lower, EE Lower, F Andre, F André, F Liebens, Fabrice André, Franco Orsi, G Aurilio, G Bogina, G Curigliano, G Viale, Giuseppe Curigliano, HJ Chang, Ida Minchella, J Carlsson, JM Wu, L Ding, L Pusztai, LD Hoefnagel, LM Bender, LS Lindstrom, LS Steelman, Luca Fumagalli, Lucia Gelao, M Scaltriti, Marzia Locatelli, Michele De Laurentiis, MJ Higgins, N Niikura, PJ Stephens, PK Idirisinghe, R Fisher, R Simon, RJ Broom, RJ Leary, S Gupta, S Vignot, SJ Aitken, SM Edgerton, SP Shah, ST Wong, T Forshew, U Wilking, V Guarneri, W Onstenk, Y Gong, Y Nagata, YM Lo   +69 more
core   +9 more sources

Breast surgery for metastatic breast cancer [PDF]

Cochrane Database of Systematic Reviews, 2014
Metastatic breast cancer is not a curable disease, but women with metastatic disease are living longer. Surgery to remove the primary tumour is associated with an increased survival in other types of metastatic cancer. Breast surgery is not standard treatment for metastatic disease, however several recent retrospective studies have suggested that ...
Giuliano, Tosello, Maria Regina, Torloni, Bruna S, Mota, Teresa, Neeman, Rachel, Riera   +4 more
openaire   +2 more sources

Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer.

Cell, 2022
Tumor-resident intracellular microbiota is an emerging tumor component that has been documented for a variety of cancer types with unclear biological functions. Here, we explored the functional significance of these intratumor bacteria, primarily using a
A. Fu, Bingqing Yao, Tingting Dong, Yongyi Chen, Jianguo Yao, Yu Liu, Hang Li, Huiru Bai, Xiaoqin Liu, Yue Zhang, Chunhui Wang, Yajing Guo, Nanwen Li, Shang Cai   +13 more
semanticscholar   +1 more source

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases

JAMA Oncology, 2022
Key Points Question Can tucatinib, trastuzumab, and capecitabine provide systemic and intracranial benefit for patients with ERBB2 (HER2)-positive metastatic breast cancer and brain metastases?
N. Lin, R. Murthy, V. Abramson, C. Anders, T. Bachelot, P. Bedard, V. Borges, D. Cameron, L. Carey, A. J. Chien, G. Curigliano, M. DiGiovanna, K. Gelmon, G. Hortobagyi, S. Hurvitz, I. Krop, S. Loi, S. Loibl, V. Mueller, Mafalda Oliveira, E. Paplomata, M. Pegram, D. Slamon, A. Zelnak, J. Ramos, W. Feng, Eric P. Winer   +26 more
semanticscholar   +1 more source

Detection of Tumor Cell-Specific mRNA in the Peripheral Blood of Patients with Breast Cancer-Evaluation of Several Markers with Real-Time Reverse Transcription-PCR [PDF]

, 2013
It is widely known that cells from epithelial tumors, e. g., breast cancer, detach from their primary tissue and enter blood circulation. We show that the presence of circulating tumor cells (CTCs) in samples of patients with primary and metastatic ...
Alexandra Kölbl, Alix-Panabieres, Balbin, Bergqvist, Bernard, Bolke, Braun, Braun, Chang, Christian Schindlbeck, De Cremoux, Dontu, Dydensborg, Fabre-Lafay, Fleming, Frasor, Gervasoni, Giani, Guo, Hedenfalk, Inaba, Jiang, Julia Neugebauer, Kim, Klaus Friese, Konecny, Krawczyk, Kurec, Lafleur, Livak, Markou, Matthias Ilmer, Mendoza, Mitas, Moliterni, Nikseresht, Noack, Pan, Pantel, Ring, Selvamurugan, Simone Hofmann, Slamon, Smerage, Solomayer, Stefan Hutter, Tai, Udo Jeschke, Ulrich Andergassen, Vandesompele, Verena Engelstädter, Wang, Weissenstein, Wu, Wu, Zhang   +55 more
core   +3 more sources