Results 101 to 110 of about 302,269 (383)
Advanced Science, EarlyView.Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan +4 more
wiley +1 more source
Advanced Science, EarlyView.Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua +15 more
wiley +1 more source
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]
, 2014 Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
core +1 more source
The pharmacogenetics of metformin [PDF]
Diabetologia, 2017 Despite its widespread use as the first-line agent for the treatment of type 2 diabetes, it has become clear that metformin does not work optimally for everyone. Elucidating who are the likely metformin responders and non-responders is hampered by our limited knowledge of its precise molecular mechanism of action.
openaire +3 more sources
Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome [PDF]
, 2017 Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients.
Atkin, Stephen L. +3 more
core +2 more sources
Advanced Science, EarlyView.NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu +15 more
wiley +1 more source
BMC Cancer, 2018 Background Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation. Laboratory studies in RCC suggested that metformin has remarkable antitumor activities and seems to be
Muyun Wei +9 more
doaj +1 more source
Metformin use and prostate cancer risk
Medicine, 2019 Background: The relationship between metformin use and the risk of prostate cancer is still inconclusive. Therefore, we performed a systematic review and meta-analysis of all eligible cohort studies to evaluate a potential association of metformin use ...
Zhaohan Feng +5 more
semanticscholar +1 more source
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source