Results 101 to 110 of about 205,038 (298)

Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation

Advanced Science, EarlyView.
Metabolomics analyses reveal that trigonelline is markedly reduced in HFpEF hearts. Trigonelline supplementation alleviates metabolic disorders and improves cardiac function in HFpEF mice via gut microbiota‐mediated AMPK activation. Abstract Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular ...
Zhe Cheng, Xiaowen Wang, Jiang Yu, Xiaorong Li, Qing Tang, Can Qu, Ding Yang, Yuanjing Li, Yong Xia, Yongzheng Guo   +9 more
wiley   +1 more source

Comparative effectiveness of combining antidiabetic medications to treat renal impairment in patients with type 2 diabetes mellitus

Scientific Reports
The comparative renoprotective effects of metformin-GLP-1 RA (glucagon-like peptide 1 receptor agonist), metformin-DPP-4i (dipeptidyl peptidase 4 inhibitor) and metformin-oADM (other antidiabetes medication) in patients with DKD (diabetic kidney disease)
Qiu Mo, Terrence J. Adam, Steven G. Johnson, Amir Moheet, David S. Pieczkiewicz   +4 more
doaj   +1 more source

Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells.

PLoS ONE, 2019
Metformin, a widely prescribed anti-diabetic drug, shows anticancer activity in various cancer types. Few studies documented that there was a decreased level of LDL and total cholesterol in blood serum of metformin users. Based on these views, this study
Ankit Sharma, Shreetama Bandyopadhayaya, Kaushik Chowdhury, Tanu Sharma, Rekha Maheshwari, Amlan Das, Gopal Chakrabarti, Vipin Kumar, Chandi C Mandal   +8 more
doaj   +1 more source

Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis

, 2022
Zikun Wang, Juhua Luo, Yijia Zhang, Pengcheng Xun, Zhongxue Chen   +4 more
openalex   +2 more sources

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Mitochondria‐Targeted AIE Materials for Oxidative Stress‐Mediated Cancer Therapy and Beyond

Aggregate, EarlyView.
This review summarizes recent advances in mitochondria‐targeted AIE materials that enable controllable oxidative stress for cancer therapy and beyond. It highlights the potential of such exogenous oxidative stress in innovative therapeutic applications and biological regulation, while also outlining key limitations and future perspectives.
Na Hao, Bohong Chen, Xinxiang Wei, Yixuan Bao, Ru Zhang, Pu Chen, Jia Liu, Heqi Gao, Rongfu Tu, Chao Chen   +9 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Nature Communications, 2019
Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the intricate alveolar network of the lung is progressively replaced by fibrotic scars.
Vahid Kheirollahi, R. Wasnick, V. Biasin, A. Vazquez-Armendariz, Xuran Chu, A. Moiseenko, A. Weiss, J. Wilhelm, Jin-San Zhang, G. Kwapiszewska, S. Herold, R. Schermuly, B. Mari, Xiaokun Li, W. Seeger, A. Günther, S. Bellusci, E. El Agha   +17 more
semanticscholar   +1 more source

Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats

Animal Models and Experimental Medicine, EarlyView.
The experimental type 2 diabetes model in rats induced by streptozotocin and nicotinamide showed that silver nanoparticles synthesized from lemongrass extract modulate blood glucose, water and food intake, and enhance antioxidant enzyme synthesis and weight gains.
Milad Faraji, Mohammad Foad Noorbakhsh, Nasrin Kazemipour, Saeed Nazifi, Hamid Reza Moradi, Nasrollah Ahmadi, Maryam Azadmanesh   +6 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source