Results 151 to 160 of about 297,887 (387)

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Pre-Treatment with Metformin in Comparison with Post-Treatment Reduces Cerebral Ischemia Reperfusion Induced Injuries in Rats [PDF]

Bulletin of Emergency and Trauma, 2018
Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats.Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min.
Mojtaba Karimipour, Sara Shojaei Zarghani, Majid Mohajer Milani, Hamid Soraya   +3 more
doaj  

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Cell Reports, 2016
Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans.
Adam R. Konopka, Raul Ruiz Esponda, Matthew M. Robinson, Matthew L. Johnson, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Fredric E. Wondisford, Ian R. Lanza, K. Sreekumaran Nair   +9 more
doaj  

Impact of metformin, statin, aspirin and insulin on the prognosis of uHCC patients receiving first line Lenvatinib or Atezolizumab plus Bevacizumab

Scientific Reports
Recently, in Hepatocellular carcinoma (HCC) setting, the use of metformin has been associated to a trend toward worse response rate, overall survival and progression free survival in patients who received immunotherapy.
Margherita Rimini, Margarida Montes, Elisabeth Amadeo, Francesco Vitiello, Masatoshi Kudo, Toshifumi Tada, Goki Suda, Shigeo Shimose, Sara Lonardi, Fabian Finkelmeier, Francesca Salani, Lorenzo Antonuzzo, Fabio Marra, Massimo Iavarone, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Marianna Silletta, Rodolfo Sacco, Ilario Giovanni Rapposelli, Mario Scartozzi, Pella Nicoletta, Luca Aldrighetti, Mara Persano, Silvia Camera, Federico Rossari, Silvia Foti, Takashi Kumada, Atsushi Hiraoka, Hideki Iwamoto, Mario Domenico Rizzato, Vera Himmelsbach, Gianluca Masi, Mattia Corradi, Ciro Celsa, Conti Fabio, Giovanni Luca Frassineti, Stefano Cascinu, Andrea Casadei-Gardini, Jose Presa   +38 more
doaj   +1 more source

OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity

Cellular Physiology and Biochemistry, 2018
Background/Aims: Metformin treatment is reported to be associated with a lower incidence of and mortality from pancreatic cancer (PC) in type 2 diabetes patients.
Chunhua Wu, Shanhu Qiu, Xiangyun Zhu, Hao Lin, Ling Li   +4 more
doaj   +1 more source

The antidiabetic drug metformin elevates receptor tyrosine kinase activity and inositol 1,4,5-trisphosphate mass in Xenopus oocytes. [PDF]

, 1996
Bradley J. Stith, Marc L. Goalstone, R Espinoza, C Mossel, Dawn Roberts, N Wiernsperger   +5 more
openalex   +2 more sources

Effect of Metformin Use on Survival in Resectable Pancreatic Cancer: A Single-Institution Experience and Review of the Literature.

PLoS ONE, 2016
Observational studies have demonstrated that metformin use in diabetic patients is associated with reduced cancer incidence and mortality. Here, we aimed to determine whether metformin use was associated with improved survival in patients with resected ...
Chenwi M Ambe, Amit Mahipal, Jimmy Fulp, Lu Chen, Mokenge P Malafa   +4 more
doaj   +1 more source

The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome [PDF]

, 2017
Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients.
Atkin, Stephen L., Coady, Anne Marie, Kilpatrick, Eric S., Sathyapalan, Thozhukat   +3 more
core   +2 more sources

Mysterious Metformin

The Oncologist, 2009
The article examines the effects of metformin in both diabetes and cancer.
Curtis R, Chong, Bruce A, Chabner
openaire   +2 more sources