Results 151 to 160 of about 205,038 (298)
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Super-Resolution Quantification of T2DM-Induced Mitochondrial Morphology Changes and Their Implications in Pharmacodynamics of Metformin and Sorafenib [PDF]
, 2022 Yang Du +4 more
openalex +1 more source
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Cell Metabolism, 2020 Ameya Sadguru Kulkarni +2 more
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel +13 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar +2 more
wiley +1 more source
SEVERE RECALCITRANT LACTIC ACIDOSIS SECONDARY TO METFORMIN OVERDOSE IN A 63-YEAR-OLD FEMALE, CORRECTED WITH SUSTAINED LOW-EFFICIENCY DIALYSIS [PDF]
, 2023 MARIA AZIM +3 more
openalex +1 more source
Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations
Drug Testing and Analysis, EarlyView.In recent years, the detection of metformin in blood and urine samples collected from racehorses has raised concern among regulators. This study describes blood and urine concentrations and the pharmacokinetics of metformin following IV and oral administration to horses. Data presented here can be used to establish screening limits and withdrawal times
Megan E. Jacobs +5 more
wiley +1 more source
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.
New England Journal of Medicine, 2006 S. Kahn +10 more
semanticscholar +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source