Results 21 to 30 of about 320,201 (374)
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
British Journal of Cancer, 2023 Over the past 15 years, there has been great interest in the potential to repurpose the diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts being made to investigate its efficacy in a number of large randomised clinical
S. Lord, A. Harris
semanticscholar +1 more source
Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
Journal of experimental & clinical cancer research : CR, 2021 Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer.
Jingjing Yang +13 more
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Metformin ameliorates the severity of experimental Alport syndrome
Scientific Reports, 2021 Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis.
Kohei Omachi +17 more
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Erectile dysfunction as a possible important side effect of metformin: A case report [PDF]
Malaysian Family Physician, 2023 Metformin-induced sexual dysfunction is rare in patients with diabetes mellitus. Herein, we present the case of a 57-year-old man newly diagnosed with type 2 diabetes mellitus who developed erectile dysfunction following treatment with metformin 500 mg ...
Min Huang Ngu +3 more
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Clinical and Translational Science, 2021 The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann +8 more
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International Journal of Molecular Sciences, 2022 Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a well-documented correlation between glucose transporter 4
R. Herman +4 more
semanticscholar +1 more source
Cellular and Molecular Mechanisms of Metformin Action
Endocrine reviews, 2020 Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on glucose metabolism,
Traci E LaMoia, G. Shulman
semanticscholar +1 more source
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
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Metformin and Its Benefits for Various Diseases
Frontiers in Endocrinology, 2020 Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels.
Ziquan Lv, Yajie Guo
semanticscholar +1 more source
‘Massive’ metformin overdose [PDF]
British Journal of Clinical Pharmacology, 2018 Massive metformin overdose can cause metabolic acidosis with hyperlactatemia. A 55‐year‐old woman presented 5 h after multidrug overdose, including 132 g extended‐release metformin. Continuous venovenous haemodiafiltration (CVVHDF) and noradrenaline were commenced due to metabolic acidosis (pH 7.0, lactate 17 mmol l–1) and shock. Despite 3 h of CVVHDF,
Angela L. Chiew +7 more
openaire +4 more sources