Results 21 to 30 of about 297,887 (387)
Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin [PDF]
, 2020 High expression of Ki67, a proliferation marker, is associated with reduced endometrial cancer-specific survival. Pre-surgical metformin reduces tumour Ki-67 expression in some women with endometrial cancer. Metformin's anti-cancer activity may relate to
Crosbie, EJ +9 more
core +2 more sources
International Journal of Molecular Sciences, 2022 Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a well-documented correlation between glucose transporter 4
R. Herman +4 more
semanticscholar +1 more source
Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes. [PDF]
PLoS ONE, 2018 OBJECTIVE:Metformin use is restricted in patients with renal impairment due to potential excess systemic accumulation. This study evaluated the glycemic effects and safety of metformin delayed-release (Metformin DR), which targets metformin delivery to ...
Robert R Henry +8 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2020 Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.Methodology Between May 2018 and January 2019, this prospective multicenter observational study recruited ...
Asher Fawwad +10 more
doaj +1 more source
Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
Journal of experimental & clinical cancer research : CR, 2021 Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer.
Jingjing Yang +13 more
semanticscholar +1 more source
Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells [PDF]
, 2014 The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK).
AN Macintyre +29 more
core +6 more sources
BMJ Open Diabetes Research & Care, 2020 Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy.
Daan J Touw +11 more
doaj +1 more source
Metformin attenuated sepsis-related liver injury by modulating gut microbiota
Emerging Microbes and Infections, 2022 Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, its role in sepsis-related liver injury (SLI) in the elderly is unclear.
Huoyan Liang +9 more
semanticscholar +1 more source
The Review of Diabetic Studies, 2013 Metformin is well-known as an anti-diabetic drug, but it seems to possess anti-cancerous properties as well. Adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved regulator of the cellular response to the presence of low energy in all eukaryotic cells.
Angelos Evangelopoulos +2 more
openaire +6 more sources
Clinical and Translational Science, 2021 The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann +8 more
doaj +1 more source