Results 21 to 30 of about 205,038 (298)

Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin

Molecules, 2021
Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects.
Sherin Abdelrahman, Mawadda Alghrably, Marcello Campagna, Charlotte Armgard Emma Hauser, Mariusz Jaremko, Joanna Izabela Lachowicz   +5 more
doaj   +1 more source

Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model

BMJ Open Diabetes Research & Care, 2020
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by proximal tubules indirectly requires energy.
Daan J Touw, Henri G D Leuvenink, Rene A Posma, Leonie H Venema, Tobias M Huijink, Andrie C Westerkamp, A Mireille A Wessels, Nynke J De Vries, Frank Doesburg, J Roggeveld, Petra J Ottens, Maarten W Nijsten   +11 more
doaj   +1 more source

Erectile dysfunction as a possible important side effect of metformin: A case report [PDF]

Malaysian Family Physician, 2023
Metformin-induced sexual dysfunction is rare in patients with diabetes mellitus. Herein, we present the case of a 57-year-old man newly diagnosed with type 2 diabetes mellitus who developed erectile dysfunction following treatment with metformin 500 mg ...
Min Huang Ngu, Rosnani Zakaria, Maryam Mohd Zulkifli, Rahiza Bt Ab Rahman   +3 more
doaj   +1 more source

Association of vitamin B12 deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan

BMJ Open Diabetes Research & Care, 2020
Objective To assess the prevalence of vitamin B12 deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.Methodology Between May 2018 and January 2019, this prospective multicenter observational study recruited ...
Asher Fawwad, Nazish Waris, Bilal Tahir, Sobia Sabir Ali, Qazi Masroor, Salma Tanveer, Jamal Zafar, Zahid Miyan, Khalid Usman, Khursheed Ahmed, Riaz A Malik   +10 more
doaj   +1 more source

Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport

International Journal of Molecular Sciences, 2022
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a well-documented correlation between glucose transporter 4
R. Herman, N. Kravos, M. Jensterle, A. Janež, V. Dolžan   +4 more
semanticscholar   +1 more source

Metformin attenuated sepsis-related liver injury by modulating gut microbiota

Emerging Microbes and Infections, 2022
Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, its role in sepsis-related liver injury (SLI) in the elderly is unclear.
Huoyan Liang, Hengli Song, Xiaojuan Zhang, Gaofei Song, Yuze Wang, Xianfei Ding, Xiaoguang Duan, Lifeng Li, T. Sun, Q. Kan   +9 more
semanticscholar   +1 more source

Oral and intravenous pharmacokinetics of metformin with and without oral codeine intake in healthy subjects: A cross‐over study

Clinical and Translational Science, 2021
The aim of the study was to investigate if there is a clinically relevant drug interaction between metformin and codeine. Volunteers were randomized to receive on four separate occasions: (A) orally administered metformin (1 g), (B) intravenously ...
Ida Kuhlmann, Amanda Nøddebo Nyrup, Tore Bjerregaard Stage, Mette Marie Hougaard Christensen, Troels Korshøj Bergmann, Per Damkier, Flemming Nielsen, Kurt Højlund, Kim Brøsen   +8 more
doaj   +1 more source

Metformin ameliorates the severity of experimental Alport syndrome

Scientific Reports, 2021
Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis.
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai   +17 more
doaj   +1 more source

Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study

Circulation, 2022
Background: Lifestyle intervention and metformin have been shown to prevent diabetes; however, their efficacy in preventing cardiovascular disease associated with the development of diabetes is unclear. We examined whether these interventions reduced the
R. Goldberg, T. Orchard, J. Crandall, E. Boyko, M. Budoff, D. Dabelea, K. Gadde, W. Knowler, Christine G. Lee, D. Nathan, K. Watson, M. Temprosa   +11 more
semanticscholar   +1 more source

Cellular and Molecular Mechanisms of Metformin Action

Endocrine reviews, 2020
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on glucose metabolism,
Traci E LaMoia, G. Shulman
semanticscholar   +1 more source