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Metformin ameliorates the severity of experimental Alport syndrome
Scientific Reports, 2021 Metformin is widely used for the treatment of type 2 diabetes, and increasing numbers of studies have shown that metformin also ameliorates tumor progression, inflammatory disease, and fibrosis.
Kohei Omachi +17 more
doaj +1 more source
Metformin and the intestine [PDF]
Diabetologia, 2008 To the Editor: The antihyperglycaemic effect of metformin is generally attributed to a decrease in hepatic glucose output, with some additional effects that increase peripheral glucose uptake and utilisation [1]. The intestine also makes an important contribution to the glucose-lowering effect of metformin, but this is often overlooked because of a ...
Carol Wilcock +2 more
openaire +2 more sources
Cellular and Molecular Mechanisms of Metformin Action
Endocrine reviews, 2020 Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on glucose metabolism,
Traci E LaMoia, G. Shulman
semanticscholar +1 more source
Frontiers in Endocrinology, 2021 The numerous beneficial health outcomes associated with the use of metformin to treat patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals including the nematode, C.
Ibrahim Mohammed +3 more
semanticscholar +1 more source
Erectile dysfunction as a possible important side effect of metformin: A case report [PDF]
Malaysian Family Physician, 2023 Metformin-induced sexual dysfunction is rare in patients with diabetes mellitus. Herein, we present the case of a 57-year-old man newly diagnosed with type 2 diabetes mellitus who developed erectile dysfunction following treatment with metformin 500 mg ...
Min Huang Ngu +3 more
doaj +1 more source
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
New England Journal of Medicine, 2002 BACKGROUND Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are ...
W. Knowler +6 more
semanticscholar +1 more source
Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence [PDF]
, 2016 Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age-related chronic disease.
Becker, Kevin G. +9 more
core +1 more source
Metformin and Its Benefits for Various Diseases
Frontiers in Endocrinology, 2020 Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels.
Ziquan Lv, Yajie Guo
semanticscholar +1 more source
Repurposing metformin for cancer treatment: current clinical studies. [PDF]
, 2016 In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K +10 more
core +1 more source
Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
core +1 more source