Results 31 to 40 of about 320,201 (374)

Repurposing metformin for cancer treatment: current clinical studies. [PDF]

, 2016
In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer molecular mechanisms of metformin including mTOR inhibition, cytotoxic ...
Altman, Jessica K, Arya, Ayush, Carneiro, Benedito, Chae, Young Kwang, Chandra, Sunandana, Giles, Francis, Kalyan, Aparna, Kaplan, Jason, Malecek, Mary-Kate, Platanias, Leonidas, Shin, Daniel Sanghoon   +10 more
core   +1 more source

Metformin attenuated sepsis-related liver injury by modulating gut microbiota

Emerging Microbes and Infections, 2022
Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, its role in sepsis-related liver injury (SLI) in the elderly is unclear.
Huoyan Liang, Hengli Song, Xiaojuan Zhang, Gaofei Song, Yuze Wang, Xianfei Ding, Xiaoguang Duan, Lifeng Li, T. Sun, Q. Kan   +9 more
semanticscholar   +1 more source

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua, Chou, Caroline Ei Ne, Dawson, David W, Eibl, Guido, French, Samuel, Hao, Fang, Hines, O Joe, Moro, Aune, Rozengurt, Enrique, Schmidt, Andrea I, Sinnett-Smith, James   +10 more
core   +2 more sources

The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose–response of randomized clinical trials [PDF]

, 2020
Purpose: Breast cancer is a leading cause of cancer mortality in developed countries. We performed a meta-analysis of randomized clinical trials to investigate the effect of metformin on biomarkers associated with breast cancer outcomes and to explore ...
Chhabra, M., Clark, C., Gudi, S. K., Manzari, N., Mousavi, S. M., Naik, G., Rahmani, J., Thompson, J., Varkaneh, H. K., Zhang, Y.   +9 more
core   +2 more sources

The mechanisms of action of metformin

Diabetologia, 2017
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
G. Rena, D. Hardie, E. Pearson
semanticscholar   +1 more source

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Frontiers in Endocrinology, 2021
The numerous beneficial health outcomes associated with the use of metformin to treat patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals including the nematode, C.
Ibrahim Mohammed, M. Hollenberg, H. Ding, C. Triggle   +3 more
semanticscholar   +1 more source

Patient-factors associated with metformin steady-state levels in type 2 diabetes mellitus with therapeutic dosage

Journal of Clinical & Translational Endocrinology, 2018
Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum, Zullies Ikawati, Ahmad H. Sadewa, Mohammad R. Ikhsan   +3 more
doaj   +1 more source

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Clinical and Translational Medicine, 2023
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska, Erli Gao, Sophia Müller‐Dott, Wenxue Li, Carlos Chacon Cordon, Shisheng Wang, Aurelien Dugourd, George Rosenberger, Julio Saez‐Rodriguez, Yansheng Liu   +9 more
doaj   +1 more source

A new perspective on metformin therapy in type 1 diabetes [PDF]

, 2017
Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G., Livingstone, Rachel, Petrie, John R.   +2 more
core   +1 more source

COMPARISON OF BLADDER CANCER CELLS APOPTOSIS INDUCED BY METFORMIN, CISPLATIN, AND COMBINATION OF METFORMIN-CISPLATIN: IN VITRO STUDY

Jurnal Urologi Indonesia, 2020
Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol, Lukman Hakim, Doddy M Soebadi, Tarmono Djojodimedjo   +3 more
doaj   +1 more source