Results 31 to 40 of about 302,269 (383)
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua +10 more
core +2 more sources
Journal of Clinical & Translational Endocrinology, 2018 Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum +3 more
doaj +1 more source
A new perspective on metformin therapy in type 1 diabetes [PDF]
, 2017 Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in support of this is limited.
Boyle, James G. +2 more
core +1 more source
The mechanisms of action of metformin
Diabetologia, 2017 Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
G. Rena, D. Hardie, E. Pearson
semanticscholar +1 more source
Jurnal Urologi Indonesia, 2020 Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol +3 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The purpose of this study was to analyze the time course and dose effect from metformin on body mass index (BMI) in children and adolescents by model-based meta-analysis (MBMA).
Dong-Dong Wang +5 more
doaj +1 more source
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]
, 2018 The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio, +11 more
core +1 more source
Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind
World Journal of Diabetes, 2021 To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent,
M. Infante +3 more
semanticscholar +1 more source
Metformin use in pregnancy: promises and uncertainties [PDF]
, 2017 Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core +1 more source
Frontiers in Medicine, 2021 Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis remains limited. There still was a controversial about association between preadmission metformin use and mortality in sepsis patients with diabetes.
Qilin Yang +7 more
semanticscholar +1 more source