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Clinical and Translational Medicine, 2023 Background The biguanide drug metformin is a safe and widely prescribed drug for type 2 diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role of metformin in the prevention and treatment of cancer including ...
Barbora Salovska +9 more
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Metformin and Its Benefits for Various Diseases
Frontiers in Endocrinology, 2020 Metformin is a widely used biguanide drug due to its safety and low cost. It has been used for over 60 years to treat type 2 diabetes at the early stages because of its outstanding ability to decrease plasma glucose levels.
Ziquan Lv, Yajie Guo
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Journal of Clinical & Translational Endocrinology, 2018 Aims: This prospective study aimed to analyze metformin steady-state concentration in repeated constant dosage and the influencing patient-factors as well as to correlate them with glycemic control.
Vitarani D.A. Ningrum +3 more
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Frontiers in Endocrinology, 2021 The numerous beneficial health outcomes associated with the use of metformin to treat patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals including the nematode, C.
Ibrahim Mohammed +3 more
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Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner
OncoImmunology, 2021 Metformin, a drug prescribed to treat type 2 diabetes, has been reported to possess antitumor activity via immunity activation. However, the influence of metformin on natural killer (NK) cells is not fully understood.
Wenjiao Xia +7 more
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Frontiers in Pharmacology, 2021 The purpose of this study was to analyze the time course and dose effect from metformin on body mass index (BMI) in children and adolescents by model-based meta-analysis (MBMA).
Dong-Dong Wang +5 more
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Jurnal Urologi Indonesia, 2020 Objective: To evaluate the effect of metformin, cisplatin, and their combination on apoptosis of bladder cancer cells. Material & Methods: Urothelial cell lines 5637 were cultured until 80% confluence.
Arifai Lumbangaol +3 more
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The mechanisms of action of metformin
Diabetologia, 2017 Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood.
G. Rena, D. Hardie, E. Pearson
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Long-term metformin therapy and vitamin B12 deficiency: An association to bear in mind
World Journal of Diabetes, 2021 To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent,
M. Infante +3 more
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Diabetes Care, 2021 OBJECTIVE To determine the longer-term effects of metformin treatment and behavioral weight loss on gut microbiota and short-chain fatty acids (SCFAs). RESEARCH DESIGN AND METHODS We conducted a 3-parallel-arm, randomized trial.
N. Mueller +7 more
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