Should metformin remain the first-line therapy for treatment of type 2 diabetes?
Therapeutic Advances in Endocrinology and Metabolism, 2021 Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is effective as monotherapy and in combination with other glucose-lowering medications.
Chelsea Baker +5 more
semanticscholar +1 more source
Metformin reverses established lung fibrosis in a bleomycin model
Nature Network Boston, 2018 Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2–4. AMPK is a critical sensor of
S. Rangarajan +13 more
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Metformin limits osteoarthritis development and progression through activation of AMPK signalling
Annals of the Rheumatic Diseases, 2020 Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. Methods Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase
Jun Li +15 more
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Diabetes, Metabolic Syndrome and Obesity, 2021 Thanida Tangjarusritaratorn,1 Watip Tangjittipokin,1,2 Tada Kunavisarut3 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence in Diabetes and Obesity, Faculty of ...
Tangjarusritaratorn T +2 more
doaj
Differential and Joint Effects of Metformin and Statins on Overall Survival of Elderly Patients with Pancreatic Adenocarcinoma: A Large Population-Based Study. [PDF]
, 2017 Background: Published evidence indicates that individual use of metformin and statin is associated with reduced cancer mortality. However, their differential and joint effects on pancreatic cancer survival are inconclusive.Methods: We identified a large ...
Demissie, Kitaw +9 more
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Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
International Journal on Biological Sciences, 2019 Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated protein kinase (AMPK) that blocks mitochondrial complex I.
Fan Yang +10 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Clinical Epigenetics, 2017 Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance.
Sonia García-Calzón +6 more
doaj +1 more source
Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS : a systematic review [PDF]
, 2014 Peer reviewedPublisher ...
Colleran, Rebecca +5 more
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Metformin - For the dermatologist
Indian Journal of Pharmacology, 2016 Metformin though primarily an antidiabetic drug, has found to play an important role in a number of cutaneous disorders. Because of its role in improving hyperinsulinemia, it has proven beneficial in hormonal acne, hidradenitis suppurativa (HS) and acanthosis nigricans.
openaire +3 more sources