Results 61 to 70 of about 297,887 (387)

Metformin in pregnancy

Polish Gynaecology, 2014
Metformin is an oral insulin-sensitizing anti-diabetic drug. Polycystic ovary syndrome (PCOS) and gestational diabetes (GDM) are both associated with insulin resistance and hyperinsulinemia. Metformin can bring potential benefits in pregnant women due to its favorable metabolic effect.
Małgorzata Bińkowska, Julia Bijok, Grzegorz Jakiel   +2 more
openaire   +3 more sources

Effect of metformin on the spatial memory in aged rats [PDF]

, 2015
Background: Aging process is often accompanied with some degree of decline in all the abilities, including learning and memory. One of the attracting research fields has been devoted to finding antiaging drugs.
Ashrostaghi, Z., Ganji, F., Sepehri, H.
core   +1 more source

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis

American Journal of Tropical Medicine and Hygiene, 2020
. Metformin was proposed to be a candidate for host-directed therapy for COVID-19. However, its efficacy remains to be validated. In this study, we compared the outcome of metformin users and nonusers in hospitalized COVID-19 patients with diabetes ...
P. Luo, Lin Qiu, Yi Liu, Xiu-lan Liu, Jian-ling Zheng, Huiying Xue, Wen-hua Liu, Dong Liu, Juan Li   +8 more
semanticscholar   +1 more source

Analysis of Time Course and Dose Effect From Metformin on Body Mass Index in Children and Adolescents

Frontiers in Pharmacology, 2021
The purpose of this study was to analyze the time course and dose effect from metformin on body mass index (BMI) in children and adolescents by model-based meta-analysis (MBMA).
Dong-Dong Wang, Yi-Zhen Mao, Su-Mei He, Xiao Chen, Xiao Chen, Xiao Chen   +5 more
doaj   +1 more source

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]

, 2018
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio,, de Pablos, Rocío M.,, Deierborg, Tomas,, Espinosa-Oliva, Ana M.,, García-Domínguez, Irene,, Herrera, Antonio J.,, Ismaiel, Afrah Abdul,, Lund University., Lund University., Machado, Alberto,, Tayara, Khadija,, Venero, José L.,   +11 more
core   +1 more source

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

Annals of the Rheumatic Diseases, 2020
Objectives In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression. Methods Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase
Jun Li, Bin Zhang, Weixiao Liu, Ke Lu, H. Pan, Tingyu Wang, C. Oh, Dan Yi, Jian Huang, Lan Zhao, G. Ning, Cong Xing, G. Xiao, R. Liu-Bryan, S. Feng, Di Chen   +15 more
semanticscholar   +1 more source

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 [PDF]

, 2014
The antiglycemic drug metformin, widely prescribed as first-line treatment of type II diabetes mellitus, has lifespan-extending properties. Precisely how this is achieved remains unclear.
Billen, Johan, Braeckman, Bart, De Haes, Wouter, Depuydt, Geert, Frooninckx, Lotte, Schoofs, Liliane, Smolders, Arne, Temmerman, Liesbet, Van Assche, Roel   +8 more
core   +1 more source

Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

Clinical Epigenetics, 2017
Background Given that metformin is the most common pharmacological therapy for type 2 diabetes, understanding the function of this drug is of great importance.
Sonia García-Calzón, Alexander Perfilyev, Ville Männistö, Vanessa D. de Mello, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling   +6 more
doaj   +1 more source

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

Journal for ImmunoTherapy of Cancer, 2022
Background Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial ...
Maria A Lehn, Trisha M Wise-Draper, Shuchi Gulati, Vinita Takiar, Sarah Palackdharry, Mario Medvedovic, Timothy Stone, Joseph Curry, Vidhya Karivedu, McKenzie Crist, Benyamin Yaniv, Michael Borchers, Bethany Fuhrman, Audrey Crago, Ubaldo Martinez-Outschoorn   +14 more
doaj   +1 more source