Results 11 to 20 of about 726,838 (122)

The Haemonchus contortus LGC-39 subunit is a novel subtype of an acetylcholine-gated chloride channel.

International Journal for Parasitology: Drugs and Drug Resistance, 2023
The nematode genome exhibits a vast array of Cys-loop receptors that are activated by a diverse set of neurotransmitters and anthelmintic drugs such as ivermectin and levamisole.
Sarah A Habibi, Kristen Nazareth, J. Nichols, Sierra Varley, S. Forrester   +4 more
semanticscholar   +3 more sources

PVC Nanoplastics Exposure Exacerbates Asthma through R-Loop Accumulation and Subsequent STING Activation in Macrophages. [PDF]

Adv Sci (Weinh)
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Bao Q, Huang Y, Deng M, Zhang C, Zu D, He H, Hu Y, Zhong Y, Liang C, Liu H, Dai W, He Y, Teng Y, Jing J, Shi Y, Cheng X, Ye Z.   +16 more
europepmc   +2 more sources

Pulmonary surfactant and prostaglandin E₂ in airway smooth muscle relaxation of human and male guinea pigs. [PDF]

Physiol Rep
The relaxant effect of pulmonary surfactant on airway smooth muscle (Prostaglandin E2). Abstract Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism of
Hanusrichterova J, Kolomaznik M, Barosova R, Adamcakova J, Mokra D, Mokry J, Skovierova H, Kelly MM, de Heuvel E, Wiehler S, Proud D, Shen H, Mukherjee PG, Amrein MW, Calkovska A.   +14 more
europepmc   +2 more sources

Methacholine Chloride [PDF]

Definitions, 2020
openaire   +2 more sources

Etiologies and Treatment Outcomes of Chronic Cough Diagnosed with a Pathophysiological Diagnostic Procedure: A Single-center Retrospective Observational Cohort Study [PDF]

Thorac Res Pract
OBJECTIVE: We developed a pathophysiological diagnostic procedure to identify etiologies of chronic cough (CC) like cough variant asthma (CVA), atopic cough (AC), cough predominant asthma, sinobronchial syndrome (SBS), and mucoid impaction of small ...
Hara J, Fujimura M, Yasui M, Takeda R, Ohkura N, Yano S.   +5 more
europepmc   +2 more sources

Smooth Muscle Hypocontractility and Airway Normoresponsiveness in a Mouse Model of Pulmonary Allergic Inflammation

Frontiers in Physiology, 2021
The contractility of airway smooth muscle (ASM) is labile. Although this feature can greatly modulate the degree of airway responsiveness in vivo, the extent by which ASM’s contractility is affected by pulmonary allergic inflammation has never been ...
Magali Boucher, Cyndi Henry, Alexis Dufour-Mailhot, Fatemeh Khadangi, Ynuk Bossé   +4 more
doaj   +1 more source

Comparison of arterial storage conditions for delayed arterial ring testing

JVS - Vascular Science, 2023
Objective: Arterial ring testing is the gold standard for measuring arterial function. Increased arterial tone through arterial contraction and impaired endothelial relaxation (endothelial dysfunction) are key metrics of impaired arterial health in ...
Dylan K. McLaughlin, MD, Carson Hoffmann, MD, Maiko Sasaki, MS, MPH, Feifei Li, MD, Jing Ma, BS, Xiangqin Cui, PhD, Roy L. Sutliff, PhD, Luke P. Brewster, MD, PhD   +7 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Deron Herr, Morley D. Hollenberg, Nicholas D. Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Xaria X. Li, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Davide Malfacini, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Philippe Rondard, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Khuraijam Dhanachandra Singh, Craig M. Smith, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Chengcan Yao, Richard D. Ye   +165 more
wiley   +1 more source

The effect of nose clip on exercise‐induced bronchoconstriction in adolescents

Pediatric Pulmonology, Volume 58, Issue 9, Page 2647-2655, September 2023., 2023
Abstract Background Oral breathing is considered to increase hyper‐responsiveness of the airways. Data on the need for nose clip (NC) during exercise challenge test (ECT) in children and adolescents is scarce. Ouraim was to evaluate the role of NC during ECT in children and adolescents.
Ilia Spivak, Guy Gut, Moneera Hanna, Michal Gur, George Shallufi, Yael Ben‐David, Vered Nir, Fahed Hakim, Lea Bentur, Ronen Bar‐Yoseph   +9 more
wiley   +1 more source

Pulmonary Function Tests in Thunderstorm-associated Respiratory Symptoms: A Cross-sectional Study [PDF]

Iranian Journal of Medical Sciences
Background: Epidemic thunderstorm asthma is an observed increase in cases of acute bronchospasm following thunderstorms. This study aimed to compare the frequency of obstructive airway disease or bronchial hyperresponsiveness in subjects with ...
Maryam Haddadzadeh Shoushtari, Sakineh Afrakhteh, Seyed Hamid Borsi, Hanieh Raji, Esmaeil Idani   +4 more
doaj   +1 more source