Results 31 to 40 of about 726,838 (122)

Accuracy of spirometry for detection of asthma: a cross-sectional study

São Paulo Medical Journal
BACKGROUND: Asthma is a chronic inflammatory disease with airway hyperresponsiveness. Spirometry is the most commonly used test among asthmatic patients. Another functional test used for diagnosing asthma is the bronchial challenge test. The aim of this
Andréa Cristina Meneghini, Ana Carolina Botto Paulino, Luciano Penha Pereira, Elcio Oliveira Vianna   +3 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman   +206 more
wiley   +1 more source

Differential Modulation of Dopamine D2 Receptor on Somatostatin and Parvalbumin Interneurons in the CA1 Area of the Dorsal Hippocampus

European Journal of Neuroscience, Volume 62, Issue 1, July 2025.
In this current study, we investigated the cellular mechanisms underlying dopaminergic modulation in the hippocampus by combining pharmacology and electrophysiology in organotypic hippocampal slices. We identified that dopamine D2 receptors are expressed in somatostatin and, to a lesser extent, parvalbumin interneurons.
Pola Tuduri, Audrey Mignon, Emmanuel Valjent, Jeanne Ster   +3 more
wiley   +1 more source

Systemic EP4 receptor agonist and Arginase‐1 therapy in a murine model of chronic asthma and influenza virus‐induced asthma exacerbation

British Journal of Pharmacology, Volume 182, Issue 12, Page 2803-2820, June 2025.
Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange, Tobias Brunn, Charlotte Vetter, Konstantin Bloch, Nora Vedder, Chiel van Geffen, Philipp Gercke, Saeed Kolahian   +7 more
wiley   +1 more source

STING‐dependent induction of neutrophilic asthma exacerbation in response to house dust mite

Allergy, Volume 80, Issue 3, Page 715-737, March 2025.
This study investigates whether STING‐induced neutrophilic lung inflammation mimics severe asthma. STING activation during allergic challenge triggers neutrophilic asthma accompanied by a Th1 and pro‐inflammatory cytokine in addition to the Th2 cytokines resulting in an epithelial barrier damage, cell death and self‐dsDNA release with increased mucus ...
Yasmine Messaoud‐Nacer, Elodie Culerier, Stéphanie Rose, Isabelle Maillet, Rania Boussad, Chloé Veront, Florence Savigny, Bernard Malissen, Urszula Radzikowska, Milena Sokolowska, Gabriel V. L. da Silva, Michael R. Edwards, David J. Jackson, Sebastian L. Johnston, Bernhard Ryffel, Valerie F. Quesniaux, Dieudonnée Togbe   +16 more
wiley   +1 more source

Agonism of the TMEM16A Calcium-Activated Chloride Channel Modulates Airway Smooth Muscle Tone.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2019
TMEM16A (anoctamin 1) is an important calcium-activated chloride channel (CaCC) in airway smooth muscle (ASM). We have previously shown that TMEM16A antagonists such as benzbromarone relax ASM and have proposed TMEM16A antagonists as novel therapies for ...
J. Danielsson, A. Kuforiji, G. Yocum, Yi Zhang, Dingbang Xu, G. Gallos, C. Emala   +6 more
semanticscholar   +1 more source

Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring

Advanced Science, Volume 12, Issue 2, January 13, 2025.
Bioreceptor‐based wearable electrochemical sensors have opened new avenues for on‐body and continuous molecular detections, enabling personalized and preventive healthcare. This review summarises recent innovations and applications of those wearable biosensing systems in detecting a variety of biochemical markers, such as small molecules, hormones ...
Haowei Duan, Shuhua Peng, Shuai He, Shi‐Yang Tang, Keisuke Goda, Chun H. Wang, Ming Li   +6 more
wiley   +1 more source

On the health effects of curcumin and its derivatives

Food Science &Nutrition, Volume 12, Issue 11, Page 8623-8650, November 2024.
Curcuma longa has therapeutic properties that have gained prodigious consideration from scientists in the medical field—review of the existing clinical and animal studies of curcumin and its by‐products. The biological properties of curcumin, also known as 1,7‐bis (4‐hydroxy‐3‐methoxyphenyl)‐1,6‐heptadiene‐3,5‐dione, or diferuloylmethane, include anti ...
Hudda Ayub, Mahad Islam, Munnaza Saeed, Husnat Ahmad, Fahad Al‐Asmari, Mohamed Fawzy Ramadan, Mohammed Alissa, Muhammad Adnan Arif, Muhammad Umair Jamil Rana, Muhammad Subtain, Muhammad Abdul Rahim, Eliasse Zongo, Nazir Ahmad   +12 more
wiley   +1 more source

Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs

Brazilian Journal of Medical and Biological Research, 2005
Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms.
Kasahara D.I., Perini A., Lopes F.D.T.Q.S., Arantes-Costa F.M., Martins M.A., Nunes M.P.T.   +5 more
doaj  

The impact of IL‐10 and IL‐17 on myeloid‐derived suppressor cells in vitro and in vivo in a murine model of asthma

European Journal of Immunology, Volume 54, Issue 7, July 2024.
IL‐10 and IL‐17 exhibited diverse impacts on regulating MDSCs and airway inflammation. In vitro, IL‐10 deficiency increased polymorphonuclear (PMN)‐MDSC numbers without affecting their suppressive activity in bone marrow, lung, and spleen. In the asthma model, IL‐17 deficiency decreased monocytic (M)‐MDSC numbers and suppressive activity in the lung ...
Charlotte Vetter, Jakob Schieb, Nora Vedder, Tim Lange, Tobias Brunn, Chiel van Geffen, Philipp Gercke, Saeed Kolahian   +7 more
wiley   +1 more source