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Inconsequential role for chemerin‐like receptor 1 in the manifestation of ozone‐induced lung pathophysiology in male mice

Physiological Reports, Volume 12, Issue 8, April 2024.
Abstract We executed this study to determine if chemerin‐like receptor 1 (CMKLR1), a Gi/o protein‐coupled receptor expressed by leukocytes and non‐leukocytes, contributes to the development of phenotypic features of non‐atopic asthma, including airway hyperresponsiveness (AHR) to acetyl‐β‐methylcholine chloride, lung hyperpermeability, airway ...
Richard A. Johnston +8 more
wiley +1 more source

Group III secreted phospholipase A2‐driven lysophospholipid pathway protects against allergic asthma

The FASEB Journal, Volume 38, Issue 2, 31 January 2024.
This study focuses on the role of group III‐secreted PLA2 (sPLA2‐III) in asthma pathology. sPLA2‐III deficiency exacerbated allergen‐induced asthmatic responses by reducing lysophospholipid levels in the lung. Agonists for lysophosphatidic acid (LPA) receptor 2 reduced TSLP expression in bronchial epithelial cells and reversed airway ...
Asako Hamu‐Tanoue +13 more
wiley +1 more source

STAT6‐induced production of mucus and resistin‐like molecules in lung Club cells does not protect against helminth or influenza A virus infection

European Journal of Immunology, Volume 54, Issue 1, January 2024.
The selective overexpression of constitutively activated STAT6vt in lung Club cells results in enhanced mucus production and expression of the resistin‐like molecule alpha. This alteration shows no impact on eosinophil recruitment, N. brasiliensis infection, A. fumigatus induced allergic airway inflammation, or influenza A virus infection.
Andreas Ruhl +5 more
wiley +1 more source

The Lower Urinary Tract Science Group Abstracts—ICI‐RS 2024