Results 1 to 10 of about 4,916 (105)
Profibrotic predictive toxicology in the lung [PDF]
Frontiers in PharmacologyIntroductionFibrosis in the gossamer alveolar capillary membranes of the lung can lead to abnormalities in gas exchange, hypoxemia and death of the individual.
Pooja Singh +2 more
doaj +2 more sources
Variation in CFTR-dependent 'β-sweating' among healthy adults.
PLoS ONE, 2022 The genetic disease cystic fibrosis (CF) results when mutations in the gene for the anion channel CFTR reduce CFTR's activity below a critical level. CFTR activity = N·PO·γ (number of channels x open probability x channel conductance).
Lesje DeRose +5 more
doaj +2 more sources
Electrophysiological and ultrastructural events evoked by methacholine and intracellular photolysis of caged compounds in cultured ovine trachea submucosal gland cells [PDF]
Experimental Physiology, 1996 Cultured ovine trachea submucosal gland cells release lysozyme in response to extracellular application of secretagogues, including the muscarinic receptor agonist methacholine (20 microM). Investigation of the ultrastructure has shown that these cells contain electron‐dense cored granules, which differ from the intact tissue, but appear to be released
A, Griffin, T M, Newman, R H, Scott
openaire +2 more sources
Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. [PDF]
PLoS ONE, 2014 Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental trigger. Calcitonin gene-related peptide (CGRP) is a neuropeptide that may have a pathological role
Manyu Li +6 more
doaj +1 more source
Molecules, 2020 In the present work, the anti-inflammatory and antiasthmatic potential of biseugenol, isolated as the main component from n-hexane extract from leaves of Nectandra leucantha and chemically prepared using oxidative coupling from eugenol, was evaluated in ...
Vitor Ponci +11 more
doaj +1 more source
Electronic Nose Breathprints Are Independent of Acute Changes in Airway Caliber in Asthma
Sensors, 2010 Molecular profiling of exhaled volatile organic compounds (VOC) by electronic nose technology provides breathprints that discriminate between patients with different inflammatory airway diseases, such as asthma and COPD.
Jan van der Maten +7 more
doaj +1 more source
Respiratory Research, 2003 Background The link between eosinophils and the development of airway hyperresponsiveness (AHR) in asthma is still controversial. This question was assessed in a murine model of asthma in which we performed a dose ranging study to establish whether the ...
McCluskie Kerryn +4 more
doaj +1 more source
Immunity, Inflammation and DiseaseBackground Particulate β‐glucans (WGP) are natural compounds with regulatory roles in various biological processes, including tumorigenesis and inflammatory diseases such as allergic asthma.
Jianzhou Zheng +6 more
doaj +1 more source
A novel quinoline with airway relaxant effects and anti-inflammatory properties
Respiratory ResearchBackground In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment.
Jesper Bergwik +8 more
doaj +1 more source
Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle
International Journal of COPD, 2017 Nooreen Shaikh,1,2 Malcolm Johnson,3 David A Hall,4 Kian Fan Chung,1,2 John H Riley,3 Sally Worsley,5 Pankaj K Bhavsar1,2 1Experimental Studies, National Heart and Lung Institute, Imperial College London, 2Biomedical Research Unit, Royal Brompton and ...
Shaikh N +6 more
doaj