Results 11 to 20 of about 4,916 (105)

Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma? [PDF]

, 2014
The authors acknowledge the medical writing assistance received from Sam Yarwood, PhD, of Complete HealthVizion, in the form of literature searches and preparation and revision of the draft manuscript.Peer reviewedPublisher ...
Fromer, Leonard, Kaplan, Alan, Price, David, Román-Rodríguez, Miguel, van der Molen, Thys   +4 more
core   +11 more sources

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]

, 2013
Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M, Franzi, Lisa M, Kenyon, Nicholas J, Lam, Kit S, Lee, Joyce, Luo, Juntao, Zeki, Amir A   +6 more
core   +8 more sources

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]

, 2018
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J., Broad, Lisa M., Brooke, Simon M., Bundgaard, Christoffer, Christopoulos, Arthur, Crabtree, Michael D., Dwomoh, Louis, Felder, Christian C., Langmead, Christopher J., Mogg, Adrian J., Molloy, Colin, Sanger, Helen E., Sexton, Patrick M., Thompson, Karen J., Tobin, Andrew B.   +14 more
core   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Gibson, Anthony, Holz, Olaf, Janicki, Stanislawa, Jörres, Rudolf A., Kanniess, Frank, Magnussen, Helgo, Richter, Kai, Simpson, Kathy J., Tal-Singer, Ruth, Vessey, Rupert S. J.   +9 more
core   +1 more source

An electronic nose in the discrimination of patients with asthma and controls. [PDF]

, 2007
BACKGROUND: Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition.
Bel, Eh, Dragonieri, S, Gauw, Sa, LE CESSIE, S, Mertens, Bj, Rabe, Kf, Resta, O, Schot, R, Spanevello, Antonio, Sterk, Pj, Vink, Tj, Willard, Np   +11 more
core   +1 more source

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L., Alikhani V., Anderson G. P., Austin R. P., Bao Y., Baur F., Bouyssou T., Cazzola M., Connolly S., Cooper A. E., Davies S. L., Deyrup M. D., Fuso L., Giles M. E., Green S. A, Kuna P., Matera M. G., Mortimer K. J., Patton J. S., Procopiou P. A., Procopiou P. A., Roig J., Stocks M. J., Tayab Z. R., Walker J. K. L., Walland A., White M. V.   +26 more
core   +2 more sources

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma [PDF]

, 2015
Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independent of confounding systemic considerations but ...
Anderson, Barnes, Bateman, Bates, Bianchi, Braman, Brancazio, Busse, Carvalho, Cazzola, Chen, Chew, Couch, Deninger, Diamant, Driehuys, Emami, Fiscus, Frazer, Frazer, Fuchs, Gershell, Glaab, Greenwald, Haczku, Haczku, Held, Held, Herget, Holmes, Hove, Hughes, Hughes-Riley, Hylkema, Kanekal, Kucharewicz, Kurucz, Lavoie, Lederlin, Lilburn, Lilburn, Martin, Masoli, Mistry, Nelson, Oenema, Raeburn, Sanderson, Siddiqui, Siegl, Six, Smith, Stevenson, Struhar, Tan, Thomas, Uhlig, Underwood, von Bethmann, Walker, Wohlsen, Zhao, Zosky   +62 more
core   +2 more sources

Cysteinyl-leukotrienes contribute to sputum eosinophil chemotactic activity in asthmatics [PDF]

, 2006
Background: Cysteinyl-leukotrienes are lipid derived mediators involved in asthma. They are able to stimulate eosinophil chemotaxis in vitro. Induced sputum from asthmatics has been shown to contain eosinophil chemotactic activity.
Bousquet, Brightling, Dent, Dworski, Green, Hatzelmann, Laitinen, Leckie, Louis, Louis, Louis, Luijk, Pavord, Romagnoli, Spada, Spanevello, Venge, Yoo   +17 more
core   +1 more source

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma [PDF]

, 2017
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades.
Alexander Seidinger, Annika Simon, Barnes, Bernd K. Fleischmann, Chiba, Christa E. Müller, Daniela Wenzel, Evi Kostenis, Fuller, Gabriele M. König, Ian P. Hall, Kamato, Kawasaki, Kawasaki, Lee, Lelliott, Markus Kuschak, Michaela Matthey, Ralf Schröder, Richard Roberts, Suvi Annala   +20 more
core   +2 more sources

Asthma in elite athletes: Who cares? [PDF]

, 2014
Asthma or exercise-induced bronchoconstriction (EIB) is highly prevalent in athletes and if untreated has the potential to impact on their health and performance.
Hull, JH, Price, OJ
core   +1 more source