Results 121 to 130 of about 130,679 (320)

Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone

International Journal of Cell Biology, 2012
Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed calcium deregulation (DCD).
Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán   +7 more
doaj   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Looking at a Blind Spot: Using a Longitudinal Population Cohort Study to Examine Inequalities in Child Social Worker Contact Among Mothers Experiencing Domestic Abuse in Scotland

Child &Family Social Work, EarlyView.
ABSTRACT Research on inequalities in children's services in the UK highlights a lack of systematic data on parental demographics, obstructing analysis of structural factors influencing children's outcomes. Using Growing Up in Scotland, a nationally representative longitudinal child cohort study of children born in 2004–2005, we investigate social ...
Valeria Skafida, Eve Mullins, John Devaney   +2 more
wiley   +1 more source

Needle tenoscopy of the digital flexor tendon sheath in four horses

Equine Veterinary Education, EarlyView.
Summary Background Tenoscopy, performed under general anaesthesia (GA), remains the gold standard diagnostic modality for assessment of the digital flexor tendon sheath (DFTS). A cadaver study described needle tenoscopy of the DFTS in a standing horse model, but the procedure has not been reported in clinical cases.
L. J. Breen, C. M. Baldwin, J. R. Vos, A. M. Gillen, J. D. Stack   +4 more
wiley   +1 more source

Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report

Case Reports in Pediatrics
Methadone is a synthetic opioid used to treat pain and opioid dependence. Despite its benefits, accidental ingestion of methadone in pediatric patients can lead to significant morbidity and mortality.
Jessie Pappin, Greg Hansen, Tanya Holt
doaj   +1 more source

Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use

Journal of Research in Pharmacy Practice
Objective: Given the prevalence of methadone poisoning, this study was conducted to compare the cardiovascular complications following acute methadone poisoning in patients with and without a history of long-term methadone use.
Gholamali Dorooshi, Mahbod Shirmohammadi, Farzad Gheshlaghi, Arman Otroshi, Shafeajafar Zoofaghari, Nastaran Eizadi-Mood   +5 more
doaj   +1 more source

Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.

PLoS ONE, 2011
Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial.
Francina Fonseca, Rafael de la Torre, Laura Díaz, Antonio Pastor, Elisabet Cuyàs, Nieves Pizarro, Olha Khymenets, Magí Farré, Marta Torrens   +8 more
doaj   +1 more source

Quality of Life, Craving Beliefs, and Psychological Well-being in Methadone Patients: The Effectiveness of Mindfulness-Based Stress Reduction Program

, 2023
Mehdi Sharifi, Ghodsiyeh Ebrahimpour, Milad Fatehizadeh Khosh baten   +2 more
openalex   +1 more source

Distal urethral obstruction in an eight‐week‐old colt with struvite urolithiasis

Equine Veterinary Education, EarlyView.
Summary An 8‐week‐old Thoroughbred colt presented with acute colic signs. Physical examination and transcutaneous ultrasound of the abdomen and penis revealed a urinary tract obstruction in the distal urethra due to urolithiasis. A distal urethrotomy over the site of obstruction was performed to remove the urolith and relieve the obstruction.
M. T. Connaughton, A. Wilson, C. M. Baldwin   +2 more
wiley   +1 more source