Results 61 to 70 of about 130,679 (320)

Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke, Lahiru Wedasingha, Magnus Rydberg   +2 more
wiley   +1 more source

Client Acceptability for Integrating Antiretroviral Therapy in Methadone Maintenance Therapy Clinics in Sichuan, China. [PDF]

, 2017
BackgroundUsing methadone maintenance therapy (MMT) clinics to deliver antiretroviral therapy (ART) has proven to be effective for promoting treatment initiation and adherence in drug users living with HIV.ObjectivesThe objective of this study was to ...
Cao, Xiaobin, Li, Li, Lin, Chunqing
core   +1 more source

Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats [PDF]

Journal of Advanced Biomedical Sciences, 2016
Background & Objective: Narcotics abuse can induce liver disorders; nevertheless, exercises improve liver disorders. The present research aimed to review the effect of eight weeks forced swimming training with methadone supplementation on liver enzymes ...
Seyed Ali Hoseini, Abdosaleh Zar, Seyed Ali Hoseini, Ghobad Hassanpour, Maryam Kheirdeh, Mehdi Noura   +5 more
doaj   +2 more sources

The relative risk of fatal poisoning by methadone or buprenorphine within the wider population of England and Wales

BMJ Open, 2015
Objective To examine the population-wide overdose risk emerging from the prescription of methadone and buprenorphine for opioid substitution treatment in England and Wales.Design Retrospective administrative data study.Setting National databases for ...
Dave Marteau, Rebecca McDonald, Kamlesh Patel   +2 more
doaj   +1 more source

Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice

Frontiers in Pharmacology, 2020
Analgesic efficacy of methadone in cancer and chronic non-cancer pains is greater than that of other opioids, probably because of its unique pharmacokinetics properties and also because it targets glutamatergic receptors in addition to µ-opioid receptors.
Valeria González, Teresa Pelissier, Victoria Cazanga, Alejandro Hernández, Luis Constandil, Luis Constandil   +5 more
doaj   +1 more source

Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

CPT: Pharmacometrics & Systems Pharmacology, 2021
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined.
Blessed W. Aruldhas, Sara K. Quinney, Brian R. Overholser, Michael A. Heathman, Andrea R. Masters, Reynold C. Ly, Hongyu Gao, Senthil Packiasabapathy, Senthilkumar Sadhasivam   +8 more
doaj   +1 more source

Identification of Factors Contributing to Methadone-Induced Daytime Sleepiness in Cancer Patients and Proposal of the Conversion Ratio from Other Opioids to Oral Methadone: A Retrospective Cohort Study

Palliative Medicine Reports, 2023
Background: When methadone is used to treat cancer pain, the Japanese health insurance system recommends to determine the starting dose according to the equivalency conversion table based on the morphine-equivalent daily dose (MEDD) of prior opioids ...
Miho Takemura, Kazuyuki Niki, Yoshiaki Okamoto, Yoshinobu Matsuda, Makie Kohno, Mikiko Ueda   +5 more
doaj   +1 more source

Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children. [PDF]

J Clin Pharmacol
Abstract Methadone is used in hospitalized children to treat pain and iatrogenic opiate withdrawal. Optimal pediatric dosing for both enteral and intravenous methadone is unknown. We conducted two prospective, multi‐center, open‐label studies to characterize the pharmacokinetics of methadone in the pediatric population.
Watt KM, Thompson EJ, Lam L, Zimmerman K, Hornik CP, Atz AM, Fernandez A, Hupp SR, Bhatt-Mehta V, Benjamin DK, Anand R, Cohen-Wolkowiez M, Gonzalez D, Smith PB, Capparelli EV, Best Pharmaceuticals for Children Act — Pediatric Trials Network Steering Committee.   +15 more
europepmc   +2 more sources

Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy

Veterinary Record, EarlyView.
Background This study measured serum biomarkers at baseline and during an ovariohysterectomy in healthy female Spanish greyhounds, aiming to enhance the objectivity of current methods for assessing acute postoperative pain in dogs. Methods Blood samples from 20 Spanish greyhounds were collected before drug administration (T0‐baseline).
Rocio Navarrete‐Calvo, Jose Andrés Fernández‐Sarmiento, Juan Morgaz, Alba Galán‐Rodríguez, Rafael J. Gómez‐Villamandos, Pablo Parra, María del Mar Granados, Setefilla Quirós‐Carmona, Irene M. Rodríguez‐Gómez   +8 more
wiley   +1 more source

Cost-effectiveness of Methadone Maintenance Treatment in prevention of HIV among drug users in Shiraz, south of Iran [PDF]

, 2014
Background: The increase in high-risk injections and unsafe sexual behaviors has led to increased HIV infection prevalence among Intravenous Drug Users (IDUs). The high costs of HIV/AIDS care and low financial resources necessitate an economic evaluation
Heidari, A., Javanbakht, M., Keshtkaran, A., Mirahmadizadeh, A.   +3 more
core   +1 more source