Results 81 to 90 of about 126,285 (384)

Retrospective analysis of low-dose methadone and QTc prolongation in chronic pain patients [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundMethadone is a synthetic opioid that is widely used for the treatment of chronic pain. The association between methadone treatment and QT interval prolongation or which can lead to torsades de pointes has been confirmed with larger studies on ...
Billy Huh, Chan-Hong Park
doaj   +1 more source

Report on Provider-Client Interaction From 68 Methadone Maintenance Clinics in China. [PDF]

, 2016
Provider-client interaction is an integral of clinical practice and central to the delivery of high-quality medical care. This article examines factors related to the provider-client interaction in the context of methadone maintenance treatment (MMT ...
Cao, Xiaobin, Comulada, W Scott, Lan, Chiao-Wen, Li, Li, Lin, Chunqing, Wu, Zunyou   +5 more
core   +1 more source

Evaluation of Therapeutic Opioids in Hair of Neonatal and Pediatric Patients

Drug Testing and Analysis, EarlyView.
This study investigated the incorporation of novel and traditional medically used opioids into the hair of 118 pediatric and neonatal patients. Concentrations (median [range]) in hair were as follows: fentanyl: 4.03 pg/mg [0.10–343], sufentanil: 0.31 pg/mg [0.10–8.64], remifentanil: 0.14 pg/mg [0.10–0.43], and morphine: 27.4 pg/mg [1.0–1870].
Max Polke, Florian Zapf, Tanja Restin, Thomas Kraemer, Tina M. Binz   +4 more
wiley   +1 more source

Evaluating the effect of chronic and continuous use of methadone on the glomerular filtration rate of patients receiving oral methadone (syrup)

Frontiers in Medicine
IntroductionThis study systematically examines the effects of chronic oral methadone use on the glomerular filtration rate (GFR) in patients participating in methadone maintenance therapy (MMT) in Qazvin City, Iran.
Valiollah Goudarzvand Chegini, Amir Mohammad Kazemifar, Amir Ershad Tavakolian, Arian Ghannadi Karimi, Arsalan Jamali Pour Sofi, Darya Ipchian, Sahand Kamali, Mehran Ebrahimi Varkiani, Zohreh Yazdi   +8 more
doaj   +1 more source

Methadone Dosage and Plasma Levels, SNPs of OPRM1 Gene and Age of First Drug Use Were Associated With Outcomes of Methadone Maintenance Treatment

Frontiers in Genetics, 2018
Objective: To explore the association between methadone dosage, plasma drug concentration, SNPs of μ-opioid receptor gene (OPRM1), ATP-binding cassette subfamily B member 1 gene (ABCB1), and methadone maintenance treatment (MMT) response.Method: A total ...
Sufang Peng, Haifeng Jiang, Jiang Du, Shuxing Lin, Shujun Pan, Shunying Yu, Min Zhao, Min Zhao, Min Zhao   +8 more
doaj   +1 more source

Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]

, 2015
Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad, A Fugelstad, Abi Lyndon, AJ Ruttenber, Anne Lingford-Hughes, AR Lingford-Hughes, B Levine, BM Mathers, CA Paronis, Chris Bailey, CK Kuo, CN Lessov, CP Bailey, CP Bailey, CP Bailey, E Kelly, E Valjent, Eamonn Kelly, EB Rex, EJ Waite, F Chen, FL Smith, FL Smith, Graeme Henderson, GS Ling, H Sakakibara, HW Matthes, HY Lin, I Rodriguez-Martin, J Llorente, J McPherson, J Reneau, JM White, Joanne Roberts, John MacLachlan, JT Williams, JW Lewis, KL McGilliard, L He, LC Hull, LC Saland, LJ Sim-Selley, LM Bohn, LQ Hong-Brown, M Aliczki, M Hickman, M Hickman, M Inoue, M Pierce, Matthew Hickman, N Quillinan, NG Shah, R Cornish, R Romberg, Rob Hill, S Darke, S Darke, S Kishioka, Sarah Withey, SJ Slater, SV Dighe, TC Green, Yvonne Kershaw   +62 more
core   +3 more sources

Detection of Methadone, LAAM, and Their Metabolites by Methadone Immunoassays [PDF]

Journal of Analytical Toxicology, 1999
l-Alpha-acetylmethadol (LAAM) was recently approved as a substitute for methadone. LAAM, methadone, and their common metabolite, methadol, are extensively N-demethylated. The structural similarities of LAAM and its metabolites to methadone suggest that they may cross-react in methadone immunoassays.
Matthew L. Cheever, David E. Moody, Gerardo A. Armendariz   +2 more
openaire   +3 more sources

Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024

ELECTROPHORESIS, EarlyView.
ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley   +1 more source

Optimizing methadone dose adjustment in patients with opioid use disorder

Frontiers in Psychiatry
IntroductionOpioid use disorder is a cause for concern globally. This study aimed to optimize methadone dose adjustments using mixed modeling and machine learning.MethodsThis retrospective study was conducted at Taichung Veterans General Hospital between
Po-Shen Liu, Teng-Yao Kuo, I-Chun Chen, I-Chun Chen, I-Chun Chen, Shu-Wua Lee, Ting-Gang Chang, Hou-Liang Chen, Jun-Peng Chen   +8 more
doaj   +1 more source

Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series

Journal of Medical Case Reports, 2011
Introduction The use of methadone as an analgesic is on the increase, but it is widely recognized that the goal of predictable and reproducible dosing is confounded by considerable variability in methadone pharmacokinetics, and unpredictable side effects
Flockhart David A, Kreutz Yvonne, Zhou Weidong, Lu Wenjie J   +3 more
doaj   +1 more source